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Role of coatings and materials of external fixation pins on the rates of pin tract infection: A systematic review and meta-analysis

BACKGROUND: Infection at the pin tract is a frequent and feared complication of external fixators (EF). The type of pin material and coatings have been regarded as possibly influencing infection rates. Over the last 20 years, few prospective clinical studies and systematic reviews addressed the role...

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Autores principales: Stoffel, Cristhopher, Eltz, Bruno, Salles, Mauro José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613683/
https://www.ncbi.nlm.nih.gov/pubmed/34888152
http://dx.doi.org/10.5312/wjo.v12.i11.920
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author Stoffel, Cristhopher
Eltz, Bruno
Salles, Mauro José
author_facet Stoffel, Cristhopher
Eltz, Bruno
Salles, Mauro José
author_sort Stoffel, Cristhopher
collection PubMed
description BACKGROUND: Infection at the pin tract is a frequent and feared complication of external fixators (EF). The type of pin material and coatings have been regarded as possibly influencing infection rates. Over the last 20 years, few prospective clinical studies and systematic reviews addressed the role of coated pins on the rate of pin site infection in human clinical studies. AIM: To assess the EF literature over the past 20 years on the clinical benefits of pins manufactured from varied materials and coating systems and their possible role in pin tract infection rates. METHODS: We performed a systematic review according to the PRISMA and PICOS guidelines using four scientific platforms: PubMed, LiLacs, SciELO, and Cochrane. We searched the literature for related publications over the past 20 years. RESULTS: A literature search yielded 29 articles, among which seven met the inclusion criteria. These studies compared stainless-steel pins and pins coated with hydroxyapatite (HA), titanium and silver. The pin tract infection definitions were arbitrary and not standardized among studies. Most studies included a low number of patients in the analysis and used a short follow-up time. Three meta-analyses were carried out, comparing stainless steel vs silver pins, stainless steel vs HA-coated pins, and titanium vs HA-coated pins. None of this analysis resulted in statistically significant differences in pin tract infection rates. CONCLUSION: Currently, no clinical evidence supports the advantage of EF pins manufactured with materials other than stainless steel or coated over uncoated pins in reducing the rates of pin tract infections. A standardized definition of pin tract infection in external fixation is still lacking.
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spelling pubmed-86136832021-12-08 Role of coatings and materials of external fixation pins on the rates of pin tract infection: A systematic review and meta-analysis Stoffel, Cristhopher Eltz, Bruno Salles, Mauro José World J Orthop Meta-Analysis BACKGROUND: Infection at the pin tract is a frequent and feared complication of external fixators (EF). The type of pin material and coatings have been regarded as possibly influencing infection rates. Over the last 20 years, few prospective clinical studies and systematic reviews addressed the role of coated pins on the rate of pin site infection in human clinical studies. AIM: To assess the EF literature over the past 20 years on the clinical benefits of pins manufactured from varied materials and coating systems and their possible role in pin tract infection rates. METHODS: We performed a systematic review according to the PRISMA and PICOS guidelines using four scientific platforms: PubMed, LiLacs, SciELO, and Cochrane. We searched the literature for related publications over the past 20 years. RESULTS: A literature search yielded 29 articles, among which seven met the inclusion criteria. These studies compared stainless-steel pins and pins coated with hydroxyapatite (HA), titanium and silver. The pin tract infection definitions were arbitrary and not standardized among studies. Most studies included a low number of patients in the analysis and used a short follow-up time. Three meta-analyses were carried out, comparing stainless steel vs silver pins, stainless steel vs HA-coated pins, and titanium vs HA-coated pins. None of this analysis resulted in statistically significant differences in pin tract infection rates. CONCLUSION: Currently, no clinical evidence supports the advantage of EF pins manufactured with materials other than stainless steel or coated over uncoated pins in reducing the rates of pin tract infections. A standardized definition of pin tract infection in external fixation is still lacking. Baishideng Publishing Group Inc 2021-11-18 /pmc/articles/PMC8613683/ /pubmed/34888152 http://dx.doi.org/10.5312/wjo.v12.i11.920 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Meta-Analysis
Stoffel, Cristhopher
Eltz, Bruno
Salles, Mauro José
Role of coatings and materials of external fixation pins on the rates of pin tract infection: A systematic review and meta-analysis
title Role of coatings and materials of external fixation pins on the rates of pin tract infection: A systematic review and meta-analysis
title_full Role of coatings and materials of external fixation pins on the rates of pin tract infection: A systematic review and meta-analysis
title_fullStr Role of coatings and materials of external fixation pins on the rates of pin tract infection: A systematic review and meta-analysis
title_full_unstemmed Role of coatings and materials of external fixation pins on the rates of pin tract infection: A systematic review and meta-analysis
title_short Role of coatings and materials of external fixation pins on the rates of pin tract infection: A systematic review and meta-analysis
title_sort role of coatings and materials of external fixation pins on the rates of pin tract infection: a systematic review and meta-analysis
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613683/
https://www.ncbi.nlm.nih.gov/pubmed/34888152
http://dx.doi.org/10.5312/wjo.v12.i11.920
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