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Clinical profile and microbiological trends of therapeutic keratoplasty at a network of tertiary care ophthalmology centers in India

OBJECTIVE: To describe the clinical profile and microbiology trends in patients undergoing therapeutic keratoplasty at a multi-tier ophthalmology hospital network in India. METHODS: This cross-sectional hospital-based study included 3147 eyes undergoing therapeutic keratoplasty between Jan 2016 and...

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Autores principales: Das, Anthony Vipin, Chaurasia, Sunita, Joseph, Joveeta, Roy, Aravind, Das, Sujata, Fernandes, Merle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613725/
https://www.ncbi.nlm.nih.gov/pubmed/34822053
http://dx.doi.org/10.1007/s10792-021-02127-y
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author Das, Anthony Vipin
Chaurasia, Sunita
Joseph, Joveeta
Roy, Aravind
Das, Sujata
Fernandes, Merle
author_facet Das, Anthony Vipin
Chaurasia, Sunita
Joseph, Joveeta
Roy, Aravind
Das, Sujata
Fernandes, Merle
author_sort Das, Anthony Vipin
collection PubMed
description OBJECTIVE: To describe the clinical profile and microbiology trends in patients undergoing therapeutic keratoplasty at a multi-tier ophthalmology hospital network in India. METHODS: This cross-sectional hospital-based study included 3147 eyes undergoing therapeutic keratoplasty between Jan 2016 and Dec 2020 (5 years period) as cases. The demographic data, clinical profile and microbiological analysis were collected using an electronic medical record system. RESULTS: Of a total of 13,625 eyes with microbial keratitis(non-viral), 3147 (23.1%) underwent therapeutic keratoplasty during the study duration. Majority of patients were males (68.35%), from a rural geography (49.89%) and in 51–60 years age bracket (23.74%). The mean age of the patients was 50.54 ± 15.83 years. Two-thirds of patients were from lower socio-economic strata (66.63%) with an agrarian background (36.51%). Of the 3,147 eyes, fungus (51.8%) was the most common indication of therapeutic keratoplasty followed by bacteria (16.87%) and parasite (1.27%). No organisms could be identified in about a third (29.33%) of the cases. Between 2016 and 2020, the trend of therapeutic keratoplasties for fungal infections steadily grew (39.9% vs 45.49%) while the bacterial infections showed a steady decline (23.15% vs 11.81%). CONCLUSIONS: Medical cure rate was seen in majority of those with microbial keratitis, and 23.1% eventually required management with therapeutic keratoplasty. Fungal keratitis was the most common indication for therapeutic keratoplasty. Male gender, rural setting, low socio-economic background and agricultural occupation are common risk factors for patients undergoing therapeutic keratoplasty in India.
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spelling pubmed-86137252021-11-26 Clinical profile and microbiological trends of therapeutic keratoplasty at a network of tertiary care ophthalmology centers in India Das, Anthony Vipin Chaurasia, Sunita Joseph, Joveeta Roy, Aravind Das, Sujata Fernandes, Merle Int Ophthalmol Original Paper OBJECTIVE: To describe the clinical profile and microbiology trends in patients undergoing therapeutic keratoplasty at a multi-tier ophthalmology hospital network in India. METHODS: This cross-sectional hospital-based study included 3147 eyes undergoing therapeutic keratoplasty between Jan 2016 and Dec 2020 (5 years period) as cases. The demographic data, clinical profile and microbiological analysis were collected using an electronic medical record system. RESULTS: Of a total of 13,625 eyes with microbial keratitis(non-viral), 3147 (23.1%) underwent therapeutic keratoplasty during the study duration. Majority of patients were males (68.35%), from a rural geography (49.89%) and in 51–60 years age bracket (23.74%). The mean age of the patients was 50.54 ± 15.83 years. Two-thirds of patients were from lower socio-economic strata (66.63%) with an agrarian background (36.51%). Of the 3,147 eyes, fungus (51.8%) was the most common indication of therapeutic keratoplasty followed by bacteria (16.87%) and parasite (1.27%). No organisms could be identified in about a third (29.33%) of the cases. Between 2016 and 2020, the trend of therapeutic keratoplasties for fungal infections steadily grew (39.9% vs 45.49%) while the bacterial infections showed a steady decline (23.15% vs 11.81%). CONCLUSIONS: Medical cure rate was seen in majority of those with microbial keratitis, and 23.1% eventually required management with therapeutic keratoplasty. Fungal keratitis was the most common indication for therapeutic keratoplasty. Male gender, rural setting, low socio-economic background and agricultural occupation are common risk factors for patients undergoing therapeutic keratoplasty in India. Springer Netherlands 2021-11-25 2022 /pmc/articles/PMC8613725/ /pubmed/34822053 http://dx.doi.org/10.1007/s10792-021-02127-y Text en © The Author(s), under exclusive licence to Springer Nature B.V. 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Paper
Das, Anthony Vipin
Chaurasia, Sunita
Joseph, Joveeta
Roy, Aravind
Das, Sujata
Fernandes, Merle
Clinical profile and microbiological trends of therapeutic keratoplasty at a network of tertiary care ophthalmology centers in India
title Clinical profile and microbiological trends of therapeutic keratoplasty at a network of tertiary care ophthalmology centers in India
title_full Clinical profile and microbiological trends of therapeutic keratoplasty at a network of tertiary care ophthalmology centers in India
title_fullStr Clinical profile and microbiological trends of therapeutic keratoplasty at a network of tertiary care ophthalmology centers in India
title_full_unstemmed Clinical profile and microbiological trends of therapeutic keratoplasty at a network of tertiary care ophthalmology centers in India
title_short Clinical profile and microbiological trends of therapeutic keratoplasty at a network of tertiary care ophthalmology centers in India
title_sort clinical profile and microbiological trends of therapeutic keratoplasty at a network of tertiary care ophthalmology centers in india
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613725/
https://www.ncbi.nlm.nih.gov/pubmed/34822053
http://dx.doi.org/10.1007/s10792-021-02127-y
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