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G-protein coupled receptors and synaptic plasticity in sleep deprivation

Insufficient sleep has been correlated to many physiological and psychoneurological disorders. Over the years, our understanding of the state of sleep has transcended from an inactive period of rest to a more active state involving important cellular and molecular processes. In addition, during slee...

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Autores principales: Parmar, Shweta, Tadavarty, Ramakrishna, Sastry, Bhagavatula R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613756/
https://www.ncbi.nlm.nih.gov/pubmed/34888167
http://dx.doi.org/10.5498/wjp.v11.i11.954
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author Parmar, Shweta
Tadavarty, Ramakrishna
Sastry, Bhagavatula R
author_facet Parmar, Shweta
Tadavarty, Ramakrishna
Sastry, Bhagavatula R
author_sort Parmar, Shweta
collection PubMed
description Insufficient sleep has been correlated to many physiological and psychoneurological disorders. Over the years, our understanding of the state of sleep has transcended from an inactive period of rest to a more active state involving important cellular and molecular processes. In addition, during sleep, electrophysiological changes also occur in pathways in specific regions of the mammalian central nervous system (CNS). Activity mediated synaptic plasticity in the CNS can lead to long-term and sometimes permanent strengthening and/or weakening synaptic strength affecting neuronal network behaviour. Memory consolidation and learning that take place during sleep cycles, can be affected by changes in synaptic plasticity during sleep disturbances. G-protein coupled receptors (GPCRs), with their versatile structural and functional attributes, can regulate synaptic plasticity in CNS and hence, may be potentially affected in sleep deprived conditions. In this review, we aim to discuss important functional changes that can take place in the CNS during sleep and sleep deprivation and how changes in GPCRs can lead to potential problems with therapeutics with pharmacological interventions.
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spelling pubmed-86137562021-12-08 G-protein coupled receptors and synaptic plasticity in sleep deprivation Parmar, Shweta Tadavarty, Ramakrishna Sastry, Bhagavatula R World J Psychiatry Review Insufficient sleep has been correlated to many physiological and psychoneurological disorders. Over the years, our understanding of the state of sleep has transcended from an inactive period of rest to a more active state involving important cellular and molecular processes. In addition, during sleep, electrophysiological changes also occur in pathways in specific regions of the mammalian central nervous system (CNS). Activity mediated synaptic plasticity in the CNS can lead to long-term and sometimes permanent strengthening and/or weakening synaptic strength affecting neuronal network behaviour. Memory consolidation and learning that take place during sleep cycles, can be affected by changes in synaptic plasticity during sleep disturbances. G-protein coupled receptors (GPCRs), with their versatile structural and functional attributes, can regulate synaptic plasticity in CNS and hence, may be potentially affected in sleep deprived conditions. In this review, we aim to discuss important functional changes that can take place in the CNS during sleep and sleep deprivation and how changes in GPCRs can lead to potential problems with therapeutics with pharmacological interventions. Baishideng Publishing Group Inc 2021-11-19 /pmc/articles/PMC8613756/ /pubmed/34888167 http://dx.doi.org/10.5498/wjp.v11.i11.954 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Review
Parmar, Shweta
Tadavarty, Ramakrishna
Sastry, Bhagavatula R
G-protein coupled receptors and synaptic plasticity in sleep deprivation
title G-protein coupled receptors and synaptic plasticity in sleep deprivation
title_full G-protein coupled receptors and synaptic plasticity in sleep deprivation
title_fullStr G-protein coupled receptors and synaptic plasticity in sleep deprivation
title_full_unstemmed G-protein coupled receptors and synaptic plasticity in sleep deprivation
title_short G-protein coupled receptors and synaptic plasticity in sleep deprivation
title_sort g-protein coupled receptors and synaptic plasticity in sleep deprivation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613756/
https://www.ncbi.nlm.nih.gov/pubmed/34888167
http://dx.doi.org/10.5498/wjp.v11.i11.954
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