Cargando…

Exploring reasons for recruitment failure in clinical trials: a qualitative study with clinical trial stakeholders in Switzerland, Germany, and Canada

BACKGROUND: Poor participant recruitment is the most frequent reason for premature discontinuation of randomized clinical trials (RCTs), particularly if they are investigator-initiated. The aims of this qualitative study were to investigate (1) the views of clinical trial stakeholders from three dif...

Descripción completa

Detalles Bibliográficos
Autores principales:	Briel, Matthias, Elger, Bernice S., McLennan, Stuart, Schandelmaier, Stefan, von Elm, Erik, Satalkar, Priya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613940/ https://www.ncbi.nlm.nih.gov/pubmed/34823582 http://dx.doi.org/10.1186/s13063-021-05818-0

Ejemplares similares

Practices and Attitudes of Swiss Stakeholders Regarding Investigator-Initiated Clinical Trial Funding Acquisition and Cost Management
por: McLennan, Stuart, et al.
Publicado: (2021)

‘It’s a nightmare’: informed consent in paediatric genome-wide sequencing. A qualitative expert interview study from Germany and Switzerland
por: Eichinger, Johanna, et al.
Publicado: (2023)

Discontinuation and non-publication of randomised clinical trials supported by the main public funding body in Switzerland: a retrospective cohort study
por: Amstutz, Alain, et al.
Publicado: (2017)

Reporting quality of clinical trial protocols: a repeated cross-sectional study about the Adherence to SPIrit Recommendations in Switzerland, CAnada and GErmany (ASPIRE-SCAGE)
por: Gryaznov, Dmitry, et al.
Publicado: (2022)

Reasons why nurses decline influenza vaccination: a qualitative study
por: Pless, Anina, et al.
Publicado: (2017)

Barriers and Facilitating Factors for Conducting Systematic Evidence Assessments in Academic Clinical Trials
por: McLennan, Stuart, et al.
Publicado: (2021)

Prediction of RECRUITment In randomized clinical Trials (RECRUIT-IT)—rationale and design for an international collaborative study
por: Kasenda, Benjamin, et al.
Publicado: (2020)

Motivations and Limits for COVID-19 Policy Compliance in Germany and Switzerland
por: Zimmermann, Bettina M., et al.
Publicado: (2021)

A systematic survey of randomised trials that stopped early for reasons of futility
por: Walter, S. D., et al.
Publicado: (2020)

Evaluation of Planned Subgroup Analysis in Protocols of Randomized Clinical Trials
por: Taji Heravi, Ala, et al.
Publicado: (2021)

Comparison of randomized controlled trials discontinued or revised for poor recruitment and completed trials with the same research question: a matched qualitative study
por: Briel, Matthias, et al.
Publicado: (2019)

Premature Discontinuation of Prospective Clinical Studies Approved by a Research Ethics Committee – A Comparison of Randomised and Non-Randomised Studies
por: Blümle, Anette, et al.
Publicado: (2016)

How do researchers acquire and develop notions of research integrity? A qualitative study among biomedical researchers in Switzerland
por: Satalkar, Priya, et al.
Publicado: (2019)

Nurses’ attitudes towards enforced measures to increase influenza vaccination: A qualitative study
por: Pless, Anina, et al.
Publicado: (2017)

Newspaper coverage on solidarity and personal responsibility in the COVID-19 pandemic: A content analysis from Germany and German-speaking Switzerland
por: Zimmermann, Bettina M., et al.
Publicado: (2023)

Advancing Academic Cancer Clinical Trials Recruitment in Canada
por: Xu, Rebecca Y., et al.
Publicado: (2021)

Scoping review and characteristics of publicly available checklists for assessing clinical trial feasibility
por: Gloy, Viktoria, et al.
Publicado: (2022)

Gatekeeping in cancer clinical trials in Canada: The ethics of recruiting the “ideal” patient
por: Bell, Jennifer A. H., et al.
Publicado: (2020)

Regulating the Secondary Use of Data for Research: Arguments Against Genetic Exceptionalism
por: Martani, Andrea, et al.
Publicado: (2019)

The full spectrum of ethical issues in pediatric genome-wide sequencing: a systematic qualitative review
por: Eichinger, Johanna, et al.
Publicado: (2021)

“Conferring Authorship”: Biobank Stakeholders’ Experiences with Publication Credit in Collaborative Research
por: Colledge, Flora M. A., et al.
Publicado: (2013)

Towards full clinical trial registration and results publication: longitudinal meta-research study in Northwestern and Central Switzerland
por: Klatte, Katharina, et al.
Publicado: (2023)

Individual notions of fair data sharing from the perspectives of Swiss stakeholders
por: Geneviève, Lester Darryl, et al.
Publicado: (2021)

Investigational medicinal products, related costs and hospital pharmacy services for investigator-initiated trials: A mixed-methods study
por: Taji Heravi, Ala, et al.
Publicado: (2022)

Access to paediatric oncology centres in Switzerland: Disparities across rural–urban and Swiss‐foreigners cohorts
por: Rauch, Sebastian, et al.
Publicado: (2022)

Stakeholder involvement in the development of trial material for a clinical trial
por: Rix, Jacqueline, et al.
Publicado: (2020)

Resource use, costs, and approval times for planning and preparing a randomized clinical trial before and after the implementation of the new Swiss human research legislation
por: Speich, Benjamin, et al.
Publicado: (2019)

Systemic Fairness for Sharing Health Data: Perspectives From Swiss Stakeholders
por: Geneviève, Lester Darryl, et al.
Publicado: (2021)

The determinants of individual health care expenditures in prison: evidence from Switzerland
por: Moschetti, Karine, et al.
Publicado: (2018)

Forensic-Psychiatric Risk Evaluations: Perspectives of Forensic Psychiatric Experts and Older Incarcerated Persons From Switzerland
por: Wangmo, Tenzin, et al.
Publicado: (2021)

Digital tools for trial recruitment and retention—plenty of tools but rigorous evaluation is in short supply
por: Treweek, Shaun, et al.
Publicado: (2020)

Exploring differences in healthcare utilization of prisoners in the Canton of Vaud, Switzerland
por: Moschetti, Karine, et al.
Publicado: (2017)

The recruitment of patients into clinical trials.
por: Tannock, I. F.
Publicado: (1995)

The Baths of Germany, France, and Switzerland
Publicado: (1857)

Trials and tribulations: obstacles to clinical trial recruitment
por: Reed, N, et al.
Publicado: (2003)

A secondary qualitative analysis of stakeholder views about participant recruitment, retention, and adherence in decentralised clinical trials (DCTs)
por: Coyle, Joanne, et al.
Publicado: (2022)

Factors influencing harmonized health data collection, sharing and linkage in Denmark and Switzerland: A systematic review
por: Geneviève, Lester Darryl, et al.
Publicado: (2019)

Methods for Incorporating Stakeholder Engagement into Clinical Trial Design
por: Ehlers, Anne P., et al.
Publicado: (2017)

Ethical insights from the COVID-19 pandemic in Germany: considerations for building resilient healthcare systems in Europe
por: Fiske, Amelia, et al.
Publicado: (2021)

Acute and transitional care or rehabilitation? Retrospective analysis of discharge planning from a municipal hospital in Switzerland
por: Kollbrunner, Lara, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_70avhe5tg8820v0bhcstg9mvla