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Sulforaphane enhances the antitumor response of chimeric antigen receptor T cells by regulating PD-1/PD-L1 pathway

BACKGROUND: Chimeric antigen receptor T (CAR-T) cell therapy has limited effects in the treatment of solid tumors. Sulforaphane (SFN) is known to play an important role in inhibiting tumor growth, but its effect on CAR-T cells remains unclear. The goal of the current study was to determine whether c...

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Detalles Bibliográficos
Autores principales:	Shen, Chunyi, Zhang, Zhen, Tian, Yonggui, Li, Feng, Zhou, Lingxiao, Jiang, Wenyi, Yang, Li, Zhang, Bin, Wang, Liping, Zhang, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614004/ https://www.ncbi.nlm.nih.gov/pubmed/34819055 http://dx.doi.org/10.1186/s12916-021-02161-8

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