2021 DORIS definition of remission in SLE: final recommendations from an international task force

OBJECTIVE: To achieve consensus on a definition of remission in SLE (DORIS). BACKGROUND: Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical...

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Detalles Bibliográficos
Autores principales: van Vollenhoven, Ronald F, Bertsias, George, Doria, Andrea, Isenberg, David, Morand, Eric, Petri, Michelle A, Pons-Estel, Bernardo A, Rahman, Anisur, Ugarte-Gil, Manuel Francisco, Voskuyl, Alexandre, Arnaud, Laurent, Bruce, Ian N, Cervera, Ricard, Costedoat-Chalumeau, Nathalie, Gordon, Caroline, Houssiau, Frédéric A, Mosca, Marta, Schneider, Matthias, Ward, Michael M, Alarcon, Graciela, Aringer, Martin, Askanase, Anca D, Bae, Sang-Cheol, Bootsma, Hendrika, Boumpas, Dimitrios T, Brunner, Hermine, Clarke, Ann Elaine, Coney, Cindy, Czirják, László, Dörner, Thomas, Faria, Raquel, Fischer, Rebecca, Fritsch-Stork, Ruth, Inanc, Murat, Jacobsen, Søren, Jayne, David, Kuhn, Annegret, van Leeuw, Bernadette, Limper, Maarten, Mariette, Xavier, Navarra, Sandra, Nikpour, Mandana, Olesinska, Marzena Helena, Pons-Estel, Guillermo, Romero-Diaz, Juanita, Rubio, Blanca, Schoenfeld, Yehuda, Bonfá, Eloisa, Smolen, Josef, Teng, Y K Onno, Tincani, Angela, Tsang-A-Sjoe, Michel, Vasconcelos, Carlos, Voss, Anne, Werth, Victoria P, Zakharhova, Elena, Aranow, Cynthia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Epidemiology and Outcomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614136/
https://www.ncbi.nlm.nih.gov/pubmed/34819388
http://dx.doi.org/10.1136/lupus-2021-000538
Descripción
Sumario:OBJECTIVE: To achieve consensus on a definition of remission in SLE (DORIS). BACKGROUND: Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical specialists published a framework for such a definition, without reaching a final recommendation. METHODS: Several systematic literature reviews were performed and specific research questions examined in suitably chosen data sets. The findings were discussed, reformulated as recommendations and voted on. RESULTS: Based on data from the literature and several SLE-specific data sets, a set of recommendations was endorsed. Ultimately, the DORIS Task Force recommended a single definition of remission in SLE, based on clinical systemic lupus erythematosus disease activitiy index (SLEDAI)=0, Evaluator’s Global Assessment <0.5 (0–3), prednisolone 5 mg/day or less, and stable antimalarials, immunosuppressives, and biologics. CONCLUSION: The 2021 DORIS definition of remission in SLE is recommended for use in clinical care, education, and research including clinical trials and observational studies.

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