An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy

We describe the discovery of an agonist of the nuclear receptor NR2F1 that specifically activates dormancy programs in malignant cells. The agonist led to a self-regulated increase in NR2F1 mRNA and protein and downstream transcription of a novel dormancy program. This program led to growth arrest o...

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Detalles Bibliográficos
Autores principales: Khalil, Bassem D., Sanchez, Roberto, Rahman, Tasrina, Rodriguez-Tirado, Carolina, Moritsch, Stefan, Martinez, Alba Rodriguez, Miles, Brett, Farias, Eduardo, Mezei, Mihaly, Nobre, Ana Rita, Singh, Deepak, Kale, Nupura, Sproll, Karl Christoph, Sosa, Maria Soledad, Aguirre-Ghiso, Julio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614154/
https://www.ncbi.nlm.nih.gov/pubmed/34812843
http://dx.doi.org/10.1084/jem.20210836

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