An Overview of Antibiotics as Emerging Contaminants: Occurrence in Bivalves as Biomonitoring Organisms

SIMPLE SUMMARY: In recent years, the use of antibiotics has increased worldwide in both human and veterinary fields. This led to them accumulating in the environment to such an extent that they are actually included in the category of contaminants of emerging concern. For this reason, many of them have been included in monitoring lists of potential pollutants by competent authorities in order to limit their concentration in surface waters and to determine the risk to the aquatic environments. From this perspective, the aim of this review is to update and discuss the available data on antibiotic residues, using bivalves as biomonitoring organisms. Bivalves are good candidate for this purpose, being globally present in large and accessible populations, sedentary and able to accumulate several xenobiotics thanks to their large filtration capacity. The current research indicates that antibiotics’ presence in bivalves has been investigated along European, American and Asian coasts. Except for tetracycline, determined at high concentration in the North Adriatic Sea, all antibiotics residues in bivalves were under the maximum residual limit established by the competent authorities. Nevertheless, further investigations are necessary in order to prevent antimicrobial resistance, preserve the environment from antibiotic pollution and monitor the associated risk for animals and humans. ABSTRACT: Antibiotics are used for therapeutic and prophylactic purposes in both human and veterinary medicine and as growth promoting agents in farms and aquaculture. They can accumulate in environmental matrices and in the food chain, causing adverse effects in humans and animals including the development of antibiotic resistance. This review aims to update and discuss the available data on antibiotic residues, using bivalves as biomonitoring organisms. The current research indicates that antibiotics’ presence in bivalves has been investigated along European, American and Asian coasts, with the majority of studies reported for the last. Several classes of antibiotics have been detected, with a higher frequency of detection reported for macrolides, sulfonamides and quinolones. The highest concentration was instead reported for tetracyclines in bivalves collected in the North Adriatic Sea. Only oxytetracycline levels detected in this latter site exceeded the maximum residual limit established by the competent authorities. Moreover, the risk that can be derived from bivalve consumption, calculated considering the highest concentrations of antibiotics residues reported in the analyzed studies, is actually negligible. Nevertheless, further supervisions are needed in order to preserve the environment from antibiotic pollution, prevent the development of antimicrobial resistance and reduce the health risk derived from seafood consumption.