Toxic Effects on Bioaccumulation, Hematological Parameters, Oxidative Stress, Immune Responses and Tissue Structure in Fish Exposed to Ammonia Nitrogen: A Review

SIMPLE SUMMARY: Ammonia nitrogen is a common environmental limiting factor in aquaculture, which can accumulate rapidly in water and reach toxic concentrations. In most aquatic environments, fish are vulnerable to the toxic effects of high levels of ammonia nitrogen exposure. It has been found that the toxic effects of ammonia nitrogen on fish are multi-mechanistic. Therefore, the purpose of this review is to explore the various toxic effects of ammonia nitrogen on fish, including oxidative stress, neurotoxicity, tissue damage and immune response. ABSTRACT: Ammonia nitrogen is the major oxygen-consuming pollutant in aquatic environments. Exposure to ammonia nitrogen in the aquatic environment can lead to bioaccumulation in fish, and the ammonia nitrogen concentration is the main determinant of accumulation. In most aquatic environments, fish are at the top of the food chain and are most vulnerable to the toxic effects of high levels of ammonia nitrogen exposure. In fish exposed to toxicants, ammonia-induced toxicity is mainly caused by bioaccumulation in certain tissues. Ammonia nitrogen absorbed in the fish enters the circulatory system and affects hematological properties. Ammonia nitrogen also breaks balance in antioxidant capacity and causes oxidative damage. In addition, ammonia nitrogen affects the immune response and causes neurotoxicity because of the physical and chemical toxicity. Thence, the purpose of this review was to investigate various toxic effects of ammonia nitrogen, including oxidative stress, neurotoxicity and immune response.