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A Multicenter Study on the Safety and Efficacy of Bronchial Thermoplasty in Adults with Severe Asthma

BACKGROUND AND AIM: Bronchial thermoplasty (BT) is a treatment option for patients with severe asthma. BT involves controlled delivery of radiofrequency energy using a bronchoscopic catheter, thereby reducing bronchial hyperreactivity. Herein, we describe our experience on the safety and efficacy of...

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Autores principales: Madan, Karan, Suri, Tejas M, Mittal, Saurabh, Maturu, Venkata Nagarjuna, Pattabhiraman, VR, Mohan, Anant, Srinivasan, Arjun, Sivaramkrishnan, Mahadevan, Prasad, KT, Agarwal, Ritesh, Tiwari, Pawan, Hadda, Vijay, Mehta, Ravindra, Guleria, Randeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614620/
https://www.ncbi.nlm.nih.gov/pubmed/34747733
http://dx.doi.org/10.4103/lungindia.lungindia_741_20
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author Madan, Karan
Suri, Tejas M
Mittal, Saurabh
Maturu, Venkata Nagarjuna
Pattabhiraman, VR
Mohan, Anant
Srinivasan, Arjun
Sivaramkrishnan, Mahadevan
Prasad, KT
Agarwal, Ritesh
Tiwari, Pawan
Hadda, Vijay
Mehta, Ravindra
Guleria, Randeep
author_facet Madan, Karan
Suri, Tejas M
Mittal, Saurabh
Maturu, Venkata Nagarjuna
Pattabhiraman, VR
Mohan, Anant
Srinivasan, Arjun
Sivaramkrishnan, Mahadevan
Prasad, KT
Agarwal, Ritesh
Tiwari, Pawan
Hadda, Vijay
Mehta, Ravindra
Guleria, Randeep
author_sort Madan, Karan
collection PubMed
description BACKGROUND AND AIM: Bronchial thermoplasty (BT) is a treatment option for patients with severe asthma. BT involves controlled delivery of radiofrequency energy using a bronchoscopic catheter, thereby reducing bronchial hyperreactivity. Herein, we describe our experience on the safety and efficacy of BT in severe asthma. METHODS: This was a retrospective multicenter study of subjects who underwent BT at four centers across India. RESULTS: We included 36 subjects (mean ± standard deviation [SD] age, 50.9 ± 11.5 years, women [69.44%]) undergoing 105 BT treatment sessions. All the subjects met the American Thoracic Society/European Respiratory Society criteria for severe asthma, 22.2% were requiring oral maintenance glucocorticoids. The mean ± SD baseline %predicted forced expiratory volume in one second (FEV1) was 62.07 ± 18.54. The median interquartile range (IQR) annual asthma exacerbation rate in the year preceding BT was 3.5 (1–10). We encountered intraprocedural complications in 7 (6.7%) sessions. An exacerbation of asthma following BT occurred in 6 (5.7%) procedures. We observed a significant improvement in the asthma control test and the asthma control questionnaire scores following BT. The quality of life (asthma quality of life questionnaire) also significantly improved. We noted a significant reduction in the number of exacerbations following BT (median [IQR], 3 [1–10] per year pre-BT versus 0.5 [0–3] per year post-BT, P < 0.001). No significant change occurred in the %predicted FEV1 following BT. CONCLUSION: BT is a feasible treatment option in patients with severe asthma. More extensive studies are required to establish the efficacy of BT in real-life settings.
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spelling pubmed-86146202021-12-13 A Multicenter Study on the Safety and Efficacy of Bronchial Thermoplasty in Adults with Severe Asthma Madan, Karan Suri, Tejas M Mittal, Saurabh Maturu, Venkata Nagarjuna Pattabhiraman, VR Mohan, Anant Srinivasan, Arjun Sivaramkrishnan, Mahadevan Prasad, KT Agarwal, Ritesh Tiwari, Pawan Hadda, Vijay Mehta, Ravindra Guleria, Randeep Lung India Original Article BACKGROUND AND AIM: Bronchial thermoplasty (BT) is a treatment option for patients with severe asthma. BT involves controlled delivery of radiofrequency energy using a bronchoscopic catheter, thereby reducing bronchial hyperreactivity. Herein, we describe our experience on the safety and efficacy of BT in severe asthma. METHODS: This was a retrospective multicenter study of subjects who underwent BT at four centers across India. RESULTS: We included 36 subjects (mean ± standard deviation [SD] age, 50.9 ± 11.5 years, women [69.44%]) undergoing 105 BT treatment sessions. All the subjects met the American Thoracic Society/European Respiratory Society criteria for severe asthma, 22.2% were requiring oral maintenance glucocorticoids. The mean ± SD baseline %predicted forced expiratory volume in one second (FEV1) was 62.07 ± 18.54. The median interquartile range (IQR) annual asthma exacerbation rate in the year preceding BT was 3.5 (1–10). We encountered intraprocedural complications in 7 (6.7%) sessions. An exacerbation of asthma following BT occurred in 6 (5.7%) procedures. We observed a significant improvement in the asthma control test and the asthma control questionnaire scores following BT. The quality of life (asthma quality of life questionnaire) also significantly improved. We noted a significant reduction in the number of exacerbations following BT (median [IQR], 3 [1–10] per year pre-BT versus 0.5 [0–3] per year post-BT, P < 0.001). No significant change occurred in the %predicted FEV1 following BT. CONCLUSION: BT is a feasible treatment option in patients with severe asthma. More extensive studies are required to establish the efficacy of BT in real-life settings. Wolters Kluwer - Medknow 2021 2021-10-26 /pmc/articles/PMC8614620/ /pubmed/34747733 http://dx.doi.org/10.4103/lungindia.lungindia_741_20 Text en Copyright: © 2021 Indian Chest Society https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Madan, Karan
Suri, Tejas M
Mittal, Saurabh
Maturu, Venkata Nagarjuna
Pattabhiraman, VR
Mohan, Anant
Srinivasan, Arjun
Sivaramkrishnan, Mahadevan
Prasad, KT
Agarwal, Ritesh
Tiwari, Pawan
Hadda, Vijay
Mehta, Ravindra
Guleria, Randeep
A Multicenter Study on the Safety and Efficacy of Bronchial Thermoplasty in Adults with Severe Asthma
title A Multicenter Study on the Safety and Efficacy of Bronchial Thermoplasty in Adults with Severe Asthma
title_full A Multicenter Study on the Safety and Efficacy of Bronchial Thermoplasty in Adults with Severe Asthma
title_fullStr A Multicenter Study on the Safety and Efficacy of Bronchial Thermoplasty in Adults with Severe Asthma
title_full_unstemmed A Multicenter Study on the Safety and Efficacy of Bronchial Thermoplasty in Adults with Severe Asthma
title_short A Multicenter Study on the Safety and Efficacy of Bronchial Thermoplasty in Adults with Severe Asthma
title_sort multicenter study on the safety and efficacy of bronchial thermoplasty in adults with severe asthma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614620/
https://www.ncbi.nlm.nih.gov/pubmed/34747733
http://dx.doi.org/10.4103/lungindia.lungindia_741_20
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