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Chronic Cholecystitis of Dogs: Clinicopathologic Features and Relationship with Liver
SIMPLE SUMMARY: This study on the gallbladders and livers of 219 client-owned dogs provides a benchmark for future studies on chronic canine cholecystitis. The statistical evaluation of clinical data; histopathology; histochemistry; and immunohistochemistry in this report provides insight into the e...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614729/ https://www.ncbi.nlm.nih.gov/pubmed/34828055 http://dx.doi.org/10.3390/ani11113324 |
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author | Mitsui, Ikki Ohtsuki, Shigeaki Uchida, Kazuyuki |
author_facet | Mitsui, Ikki Ohtsuki, Shigeaki Uchida, Kazuyuki |
author_sort | Mitsui, Ikki |
collection | PubMed |
description | SIMPLE SUMMARY: This study on the gallbladders and livers of 219 client-owned dogs provides a benchmark for future studies on chronic canine cholecystitis. The statistical evaluation of clinical data; histopathology; histochemistry; and immunohistochemistry in this report provides insight into the etiology of chronic cholecystitis in dogs ABSTRACT: (1) Background: Chronic cholecystitis of dogs has not been vigorously investigated histopathologically. In addition, the relationship between gallbladder and liver diseases is not known. (2) Methods: We aimed to provide a hallmark for canine chronic cholecystitis using clinical data, histopathology, histochemistry, immunohistochemistry, and statistical analysis. (3) Results: Our investigation of 219 ultrasonographically abnormal surgically resected canine gallbladders revealed 189 cases (86.3%) of mucosal lymphoplasmacytic infiltration (chronic cholecystitis). Sludge, a gravity-dependent or nondependent fine granular hyperechoic material, was more prevalent (105/219, 47.9%) than mucocele (51/219, 23.2%) in this cohort. Mucosal lymphoid follicles were detected in 68/219 cases (31%), suggesting the influence of long-standing antigenic stimulation. Bacteria were histochemically detected in 41/60 (68.3%) of heavily inflamed gallbladders, 18/129 (14%) of lightly inflamed, and 3/18 (16.7%) of uninflamed gallbladders, suggesting a possible relationship between bacteria and chronic cholecystitis. Simultaneous liver biopsies revealed mild or no inflammation, changes consistent with primary portal vein hypoplasia, and mild hepatocellular degeneration. (4) Conclusions: Based on the results of our statistical analysis, we conclude that canine chronic cholecystitis is a long-standing inflammatory process of unknown (but possibly bacterial) etiology and that liver pathology is unlikely the cause of chronic cholecystitis in dogs. |
format | Online Article Text |
id | pubmed-8614729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86147292021-11-26 Chronic Cholecystitis of Dogs: Clinicopathologic Features and Relationship with Liver Mitsui, Ikki Ohtsuki, Shigeaki Uchida, Kazuyuki Animals (Basel) Article SIMPLE SUMMARY: This study on the gallbladders and livers of 219 client-owned dogs provides a benchmark for future studies on chronic canine cholecystitis. The statistical evaluation of clinical data; histopathology; histochemistry; and immunohistochemistry in this report provides insight into the etiology of chronic cholecystitis in dogs ABSTRACT: (1) Background: Chronic cholecystitis of dogs has not been vigorously investigated histopathologically. In addition, the relationship between gallbladder and liver diseases is not known. (2) Methods: We aimed to provide a hallmark for canine chronic cholecystitis using clinical data, histopathology, histochemistry, immunohistochemistry, and statistical analysis. (3) Results: Our investigation of 219 ultrasonographically abnormal surgically resected canine gallbladders revealed 189 cases (86.3%) of mucosal lymphoplasmacytic infiltration (chronic cholecystitis). Sludge, a gravity-dependent or nondependent fine granular hyperechoic material, was more prevalent (105/219, 47.9%) than mucocele (51/219, 23.2%) in this cohort. Mucosal lymphoid follicles were detected in 68/219 cases (31%), suggesting the influence of long-standing antigenic stimulation. Bacteria were histochemically detected in 41/60 (68.3%) of heavily inflamed gallbladders, 18/129 (14%) of lightly inflamed, and 3/18 (16.7%) of uninflamed gallbladders, suggesting a possible relationship between bacteria and chronic cholecystitis. Simultaneous liver biopsies revealed mild or no inflammation, changes consistent with primary portal vein hypoplasia, and mild hepatocellular degeneration. (4) Conclusions: Based on the results of our statistical analysis, we conclude that canine chronic cholecystitis is a long-standing inflammatory process of unknown (but possibly bacterial) etiology and that liver pathology is unlikely the cause of chronic cholecystitis in dogs. MDPI 2021-11-21 /pmc/articles/PMC8614729/ /pubmed/34828055 http://dx.doi.org/10.3390/ani11113324 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mitsui, Ikki Ohtsuki, Shigeaki Uchida, Kazuyuki Chronic Cholecystitis of Dogs: Clinicopathologic Features and Relationship with Liver |
title | Chronic Cholecystitis of Dogs: Clinicopathologic Features and Relationship with Liver |
title_full | Chronic Cholecystitis of Dogs: Clinicopathologic Features and Relationship with Liver |
title_fullStr | Chronic Cholecystitis of Dogs: Clinicopathologic Features and Relationship with Liver |
title_full_unstemmed | Chronic Cholecystitis of Dogs: Clinicopathologic Features and Relationship with Liver |
title_short | Chronic Cholecystitis of Dogs: Clinicopathologic Features and Relationship with Liver |
title_sort | chronic cholecystitis of dogs: clinicopathologic features and relationship with liver |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614729/ https://www.ncbi.nlm.nih.gov/pubmed/34828055 http://dx.doi.org/10.3390/ani11113324 |
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