Cargando…
Physical Exercise Potentially Targets Epicardial Adipose Tissue to Reduce Cardiovascular Disease Risk in Patients with Metabolic Diseases: Oxidative Stress and Inflammation Emerge as Major Therapeutic Targets
Excess epicardial adiposity, within a state of obesity and metabolic syndrome, is emerging as an important risk factor for the development of cardiovascular diseases (CVDs). Accordingly, increased epicardial fat thickness (EFT) implicates the exacerbation of pathological mechanisms involving oxidati...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614861/ https://www.ncbi.nlm.nih.gov/pubmed/34829629 http://dx.doi.org/10.3390/antiox10111758 |
_version_ | 1784603963563180032 |
---|---|
author | Nyawo, Thembeka A. Pheiffer, Carmen Mazibuko-Mbeje, Sithandiwe E. Mthembu, Sinenhlanhla X. H. Nyambuya, Tawanda M. Nkambule, Bongani B. Sadie-Van Gijsen, Hanél Strijdom, Hans Tiano, Luca Dludla, Phiwayinkosi V. |
author_facet | Nyawo, Thembeka A. Pheiffer, Carmen Mazibuko-Mbeje, Sithandiwe E. Mthembu, Sinenhlanhla X. H. Nyambuya, Tawanda M. Nkambule, Bongani B. Sadie-Van Gijsen, Hanél Strijdom, Hans Tiano, Luca Dludla, Phiwayinkosi V. |
author_sort | Nyawo, Thembeka A. |
collection | PubMed |
description | Excess epicardial adiposity, within a state of obesity and metabolic syndrome, is emerging as an important risk factor for the development of cardiovascular diseases (CVDs). Accordingly, increased epicardial fat thickness (EFT) implicates the exacerbation of pathological mechanisms involving oxidative stress and inflammation within the heart, which may accelerate the development of CVDs. This explains increased interest in targeting EFT reduction to attenuate the detrimental effects of oxidative stress and inflammation within the setting of metabolic syndrome. Here, we critically discuss clinical and preclinical evidence on the impact of physical exercise on EFT in correlation with reduced CVD risk within a setting of metabolic disease. This review also brings a unique perspective on the implications of oxidative stress and inflammation as major pathological consequences that link increased EFT to accelerated CVD risk in conditions of metabolic disease. |
format | Online Article Text |
id | pubmed-8614861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86148612021-11-26 Physical Exercise Potentially Targets Epicardial Adipose Tissue to Reduce Cardiovascular Disease Risk in Patients with Metabolic Diseases: Oxidative Stress and Inflammation Emerge as Major Therapeutic Targets Nyawo, Thembeka A. Pheiffer, Carmen Mazibuko-Mbeje, Sithandiwe E. Mthembu, Sinenhlanhla X. H. Nyambuya, Tawanda M. Nkambule, Bongani B. Sadie-Van Gijsen, Hanél Strijdom, Hans Tiano, Luca Dludla, Phiwayinkosi V. Antioxidants (Basel) Review Excess epicardial adiposity, within a state of obesity and metabolic syndrome, is emerging as an important risk factor for the development of cardiovascular diseases (CVDs). Accordingly, increased epicardial fat thickness (EFT) implicates the exacerbation of pathological mechanisms involving oxidative stress and inflammation within the heart, which may accelerate the development of CVDs. This explains increased interest in targeting EFT reduction to attenuate the detrimental effects of oxidative stress and inflammation within the setting of metabolic syndrome. Here, we critically discuss clinical and preclinical evidence on the impact of physical exercise on EFT in correlation with reduced CVD risk within a setting of metabolic disease. This review also brings a unique perspective on the implications of oxidative stress and inflammation as major pathological consequences that link increased EFT to accelerated CVD risk in conditions of metabolic disease. MDPI 2021-11-04 /pmc/articles/PMC8614861/ /pubmed/34829629 http://dx.doi.org/10.3390/antiox10111758 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nyawo, Thembeka A. Pheiffer, Carmen Mazibuko-Mbeje, Sithandiwe E. Mthembu, Sinenhlanhla X. H. Nyambuya, Tawanda M. Nkambule, Bongani B. Sadie-Van Gijsen, Hanél Strijdom, Hans Tiano, Luca Dludla, Phiwayinkosi V. Physical Exercise Potentially Targets Epicardial Adipose Tissue to Reduce Cardiovascular Disease Risk in Patients with Metabolic Diseases: Oxidative Stress and Inflammation Emerge as Major Therapeutic Targets |
title | Physical Exercise Potentially Targets Epicardial Adipose Tissue to Reduce Cardiovascular Disease Risk in Patients with Metabolic Diseases: Oxidative Stress and Inflammation Emerge as Major Therapeutic Targets |
title_full | Physical Exercise Potentially Targets Epicardial Adipose Tissue to Reduce Cardiovascular Disease Risk in Patients with Metabolic Diseases: Oxidative Stress and Inflammation Emerge as Major Therapeutic Targets |
title_fullStr | Physical Exercise Potentially Targets Epicardial Adipose Tissue to Reduce Cardiovascular Disease Risk in Patients with Metabolic Diseases: Oxidative Stress and Inflammation Emerge as Major Therapeutic Targets |
title_full_unstemmed | Physical Exercise Potentially Targets Epicardial Adipose Tissue to Reduce Cardiovascular Disease Risk in Patients with Metabolic Diseases: Oxidative Stress and Inflammation Emerge as Major Therapeutic Targets |
title_short | Physical Exercise Potentially Targets Epicardial Adipose Tissue to Reduce Cardiovascular Disease Risk in Patients with Metabolic Diseases: Oxidative Stress and Inflammation Emerge as Major Therapeutic Targets |
title_sort | physical exercise potentially targets epicardial adipose tissue to reduce cardiovascular disease risk in patients with metabolic diseases: oxidative stress and inflammation emerge as major therapeutic targets |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614861/ https://www.ncbi.nlm.nih.gov/pubmed/34829629 http://dx.doi.org/10.3390/antiox10111758 |
work_keys_str_mv | AT nyawothembekaa physicalexercisepotentiallytargetsepicardialadiposetissuetoreducecardiovasculardiseaseriskinpatientswithmetabolicdiseasesoxidativestressandinflammationemergeasmajortherapeutictargets AT pheiffercarmen physicalexercisepotentiallytargetsepicardialadiposetissuetoreducecardiovasculardiseaseriskinpatientswithmetabolicdiseasesoxidativestressandinflammationemergeasmajortherapeutictargets AT mazibukombejesithandiwee physicalexercisepotentiallytargetsepicardialadiposetissuetoreducecardiovasculardiseaseriskinpatientswithmetabolicdiseasesoxidativestressandinflammationemergeasmajortherapeutictargets AT mthembusinenhlanhlaxh physicalexercisepotentiallytargetsepicardialadiposetissuetoreducecardiovasculardiseaseriskinpatientswithmetabolicdiseasesoxidativestressandinflammationemergeasmajortherapeutictargets AT nyambuyatawandam physicalexercisepotentiallytargetsepicardialadiposetissuetoreducecardiovasculardiseaseriskinpatientswithmetabolicdiseasesoxidativestressandinflammationemergeasmajortherapeutictargets AT nkambulebonganib physicalexercisepotentiallytargetsepicardialadiposetissuetoreducecardiovasculardiseaseriskinpatientswithmetabolicdiseasesoxidativestressandinflammationemergeasmajortherapeutictargets AT sadievangijsenhanel physicalexercisepotentiallytargetsepicardialadiposetissuetoreducecardiovasculardiseaseriskinpatientswithmetabolicdiseasesoxidativestressandinflammationemergeasmajortherapeutictargets AT strijdomhans physicalexercisepotentiallytargetsepicardialadiposetissuetoreducecardiovasculardiseaseriskinpatientswithmetabolicdiseasesoxidativestressandinflammationemergeasmajortherapeutictargets AT tianoluca physicalexercisepotentiallytargetsepicardialadiposetissuetoreducecardiovasculardiseaseriskinpatientswithmetabolicdiseasesoxidativestressandinflammationemergeasmajortherapeutictargets AT dludlaphiwayinkosiv physicalexercisepotentiallytargetsepicardialadiposetissuetoreducecardiovasculardiseaseriskinpatientswithmetabolicdiseasesoxidativestressandinflammationemergeasmajortherapeutictargets |