Pathogenic D76N Variant of β(2)-Microglobulin: Synergy of Diverse Effects in Both the Native and Amyloid States

SIMPLE SUMMARY: Elevated β(2)-microglobulin (β2m) serum levels cause serious complications in patients on long-term kidney dialysis by depositing in the form of amyloid fibrils in the osteoarticular system. Recently, a hereditary systemic amyloidosis was discovered, caused by a naturally occurring D...

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Detalles Bibliográficos
Autores principales: Bulyáki, Éva, Kun, Judit, Molnár, Tamás, Papp, Alexandra, Micsonai, András, Vadászi, Henrietta, Márialigeti, Borbála, Kovács, Attila István, Gellén, Gabriella, Yamaguchi, Keiichi, Lin, Yuxi, So, Masatomo, Józsi, Mihály, Schlosser, Gitta, Lee, Young-Ho, Liliom, Károly, Goto, Yuji, Kardos, József
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614874/
https://www.ncbi.nlm.nih.gov/pubmed/34827190
http://dx.doi.org/10.3390/biology10111197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614874/
https://www.ncbi.nlm.nih.gov/pubmed/34827190
http://dx.doi.org/10.3390/biology10111197

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