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Sulfur Administration in Fe–S Cluster Homeostasis

Mitochondria are the key organelles of Fe–S cluster synthesis. They contain the enzyme cysteine desulfurase, a scaffold protein, iron and electron donors, and specific chaperons all required for the formation of Fe–S clusters. The newly formed cluster can be utilized by mitochondrial Fe–S protein sy...

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Detalles Bibliográficos
Autores principales: Rydz, Leszek, Wróbel, Maria, Jurkowska, Halina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614886/
https://www.ncbi.nlm.nih.gov/pubmed/34829609
http://dx.doi.org/10.3390/antiox10111738
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author Rydz, Leszek
Wróbel, Maria
Jurkowska, Halina
author_facet Rydz, Leszek
Wróbel, Maria
Jurkowska, Halina
author_sort Rydz, Leszek
collection PubMed
description Mitochondria are the key organelles of Fe–S cluster synthesis. They contain the enzyme cysteine desulfurase, a scaffold protein, iron and electron donors, and specific chaperons all required for the formation of Fe–S clusters. The newly formed cluster can be utilized by mitochondrial Fe–S protein synthesis or undergo further transformation. Mitochondrial Fe–S cluster biogenesis components are required in the cytosolic iron–sulfur cluster assembly machinery for cytosolic and nuclear cluster supplies. Clusters that are the key components of Fe–S proteins are vulnerable and prone to degradation whenever exposed to oxidative stress. However, once degraded, the Fe–S cluster can be resynthesized or repaired. It has been proposed that sulfurtransferases, rhodanese, and 3-mercaptopyruvate sulfurtransferase, responsible for sulfur transfer from donor to nucleophilic acceptor, are involved in the Fe–S cluster formation, maturation, or reconstitution. In the present paper, we attempt to sum up our knowledge on the involvement of sulfurtransferases not only in sulfur administration but also in the Fe–S cluster formation in mammals and yeasts, and on reconstitution-damaged cluster or restoration of enzyme’s attenuated activity.
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spelling pubmed-86148862021-11-26 Sulfur Administration in Fe–S Cluster Homeostasis Rydz, Leszek Wróbel, Maria Jurkowska, Halina Antioxidants (Basel) Review Mitochondria are the key organelles of Fe–S cluster synthesis. They contain the enzyme cysteine desulfurase, a scaffold protein, iron and electron donors, and specific chaperons all required for the formation of Fe–S clusters. The newly formed cluster can be utilized by mitochondrial Fe–S protein synthesis or undergo further transformation. Mitochondrial Fe–S cluster biogenesis components are required in the cytosolic iron–sulfur cluster assembly machinery for cytosolic and nuclear cluster supplies. Clusters that are the key components of Fe–S proteins are vulnerable and prone to degradation whenever exposed to oxidative stress. However, once degraded, the Fe–S cluster can be resynthesized or repaired. It has been proposed that sulfurtransferases, rhodanese, and 3-mercaptopyruvate sulfurtransferase, responsible for sulfur transfer from donor to nucleophilic acceptor, are involved in the Fe–S cluster formation, maturation, or reconstitution. In the present paper, we attempt to sum up our knowledge on the involvement of sulfurtransferases not only in sulfur administration but also in the Fe–S cluster formation in mammals and yeasts, and on reconstitution-damaged cluster or restoration of enzyme’s attenuated activity. MDPI 2021-10-29 /pmc/articles/PMC8614886/ /pubmed/34829609 http://dx.doi.org/10.3390/antiox10111738 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rydz, Leszek
Wróbel, Maria
Jurkowska, Halina
Sulfur Administration in Fe–S Cluster Homeostasis
title Sulfur Administration in Fe–S Cluster Homeostasis
title_full Sulfur Administration in Fe–S Cluster Homeostasis
title_fullStr Sulfur Administration in Fe–S Cluster Homeostasis
title_full_unstemmed Sulfur Administration in Fe–S Cluster Homeostasis
title_short Sulfur Administration in Fe–S Cluster Homeostasis
title_sort sulfur administration in fe–s cluster homeostasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614886/
https://www.ncbi.nlm.nih.gov/pubmed/34829609
http://dx.doi.org/10.3390/antiox10111738
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