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Sulfur Administration in Fe–S Cluster Homeostasis
Mitochondria are the key organelles of Fe–S cluster synthesis. They contain the enzyme cysteine desulfurase, a scaffold protein, iron and electron donors, and specific chaperons all required for the formation of Fe–S clusters. The newly formed cluster can be utilized by mitochondrial Fe–S protein sy...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614886/ https://www.ncbi.nlm.nih.gov/pubmed/34829609 http://dx.doi.org/10.3390/antiox10111738 |
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author | Rydz, Leszek Wróbel, Maria Jurkowska, Halina |
author_facet | Rydz, Leszek Wróbel, Maria Jurkowska, Halina |
author_sort | Rydz, Leszek |
collection | PubMed |
description | Mitochondria are the key organelles of Fe–S cluster synthesis. They contain the enzyme cysteine desulfurase, a scaffold protein, iron and electron donors, and specific chaperons all required for the formation of Fe–S clusters. The newly formed cluster can be utilized by mitochondrial Fe–S protein synthesis or undergo further transformation. Mitochondrial Fe–S cluster biogenesis components are required in the cytosolic iron–sulfur cluster assembly machinery for cytosolic and nuclear cluster supplies. Clusters that are the key components of Fe–S proteins are vulnerable and prone to degradation whenever exposed to oxidative stress. However, once degraded, the Fe–S cluster can be resynthesized or repaired. It has been proposed that sulfurtransferases, rhodanese, and 3-mercaptopyruvate sulfurtransferase, responsible for sulfur transfer from donor to nucleophilic acceptor, are involved in the Fe–S cluster formation, maturation, or reconstitution. In the present paper, we attempt to sum up our knowledge on the involvement of sulfurtransferases not only in sulfur administration but also in the Fe–S cluster formation in mammals and yeasts, and on reconstitution-damaged cluster or restoration of enzyme’s attenuated activity. |
format | Online Article Text |
id | pubmed-8614886 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86148862021-11-26 Sulfur Administration in Fe–S Cluster Homeostasis Rydz, Leszek Wróbel, Maria Jurkowska, Halina Antioxidants (Basel) Review Mitochondria are the key organelles of Fe–S cluster synthesis. They contain the enzyme cysteine desulfurase, a scaffold protein, iron and electron donors, and specific chaperons all required for the formation of Fe–S clusters. The newly formed cluster can be utilized by mitochondrial Fe–S protein synthesis or undergo further transformation. Mitochondrial Fe–S cluster biogenesis components are required in the cytosolic iron–sulfur cluster assembly machinery for cytosolic and nuclear cluster supplies. Clusters that are the key components of Fe–S proteins are vulnerable and prone to degradation whenever exposed to oxidative stress. However, once degraded, the Fe–S cluster can be resynthesized or repaired. It has been proposed that sulfurtransferases, rhodanese, and 3-mercaptopyruvate sulfurtransferase, responsible for sulfur transfer from donor to nucleophilic acceptor, are involved in the Fe–S cluster formation, maturation, or reconstitution. In the present paper, we attempt to sum up our knowledge on the involvement of sulfurtransferases not only in sulfur administration but also in the Fe–S cluster formation in mammals and yeasts, and on reconstitution-damaged cluster or restoration of enzyme’s attenuated activity. MDPI 2021-10-29 /pmc/articles/PMC8614886/ /pubmed/34829609 http://dx.doi.org/10.3390/antiox10111738 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rydz, Leszek Wróbel, Maria Jurkowska, Halina Sulfur Administration in Fe–S Cluster Homeostasis |
title | Sulfur Administration in Fe–S Cluster Homeostasis |
title_full | Sulfur Administration in Fe–S Cluster Homeostasis |
title_fullStr | Sulfur Administration in Fe–S Cluster Homeostasis |
title_full_unstemmed | Sulfur Administration in Fe–S Cluster Homeostasis |
title_short | Sulfur Administration in Fe–S Cluster Homeostasis |
title_sort | sulfur administration in fe–s cluster homeostasis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614886/ https://www.ncbi.nlm.nih.gov/pubmed/34829609 http://dx.doi.org/10.3390/antiox10111738 |
work_keys_str_mv | AT rydzleszek sulfuradministrationinfesclusterhomeostasis AT wrobelmaria sulfuradministrationinfesclusterhomeostasis AT jurkowskahalina sulfuradministrationinfesclusterhomeostasis |