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Submicron-Sized Vermiculite Assisted Oregano Oil for Controlled Release and Long-Term Bacterial Inhibition

Oregano essential oil (OEO) is a natural compound consisting of potent antibiotic molecules. Its volatility is the major obstacle against the transportation and anti-bacterial performance. In this work, submicron-sized vermiculite (SMV) particles were prepared from Australian vermiculite clay by bal...

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Detalles Bibliográficos
Autores principales: Kothalawala, Sukitha Geethma, Zhang, Jun, Wang, Yue, Yu, Chengzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614931/
https://www.ncbi.nlm.nih.gov/pubmed/34827262
http://dx.doi.org/10.3390/antibiotics10111324
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author Kothalawala, Sukitha Geethma
Zhang, Jun
Wang, Yue
Yu, Chengzhong
author_facet Kothalawala, Sukitha Geethma
Zhang, Jun
Wang, Yue
Yu, Chengzhong
author_sort Kothalawala, Sukitha Geethma
collection PubMed
description Oregano essential oil (OEO) is a natural compound consisting of potent antibiotic molecules. Its volatility is the major obstacle against the transportation and anti-bacterial performance. In this work, submicron-sized vermiculite (SMV) particles were prepared from Australian vermiculite clay by ball milling, and tested as a potential particulate-carrier for OEO. The loading of OEO by SMV can be easily achieved by mechanical mixing. Compared to raw vermiculite and free OEO, the OEO-loaded SMV displayed sustained isothermal release behaviour of OEO and demonstrated enhanced antibacterial performance in in vitro antibacterial tests against Escherichia coli (E. coli) and Staphylococcus epidermidis (S. epidermidis). This study provides a facile and commercially viable approach in designing advantageous carriers for volatile actives in antimicrobial applications.
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spelling pubmed-86149312021-11-26 Submicron-Sized Vermiculite Assisted Oregano Oil for Controlled Release and Long-Term Bacterial Inhibition Kothalawala, Sukitha Geethma Zhang, Jun Wang, Yue Yu, Chengzhong Antibiotics (Basel) Article Oregano essential oil (OEO) is a natural compound consisting of potent antibiotic molecules. Its volatility is the major obstacle against the transportation and anti-bacterial performance. In this work, submicron-sized vermiculite (SMV) particles were prepared from Australian vermiculite clay by ball milling, and tested as a potential particulate-carrier for OEO. The loading of OEO by SMV can be easily achieved by mechanical mixing. Compared to raw vermiculite and free OEO, the OEO-loaded SMV displayed sustained isothermal release behaviour of OEO and demonstrated enhanced antibacterial performance in in vitro antibacterial tests against Escherichia coli (E. coli) and Staphylococcus epidermidis (S. epidermidis). This study provides a facile and commercially viable approach in designing advantageous carriers for volatile actives in antimicrobial applications. MDPI 2021-10-29 /pmc/articles/PMC8614931/ /pubmed/34827262 http://dx.doi.org/10.3390/antibiotics10111324 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kothalawala, Sukitha Geethma
Zhang, Jun
Wang, Yue
Yu, Chengzhong
Submicron-Sized Vermiculite Assisted Oregano Oil for Controlled Release and Long-Term Bacterial Inhibition
title Submicron-Sized Vermiculite Assisted Oregano Oil for Controlled Release and Long-Term Bacterial Inhibition
title_full Submicron-Sized Vermiculite Assisted Oregano Oil for Controlled Release and Long-Term Bacterial Inhibition
title_fullStr Submicron-Sized Vermiculite Assisted Oregano Oil for Controlled Release and Long-Term Bacterial Inhibition
title_full_unstemmed Submicron-Sized Vermiculite Assisted Oregano Oil for Controlled Release and Long-Term Bacterial Inhibition
title_short Submicron-Sized Vermiculite Assisted Oregano Oil for Controlled Release and Long-Term Bacterial Inhibition
title_sort submicron-sized vermiculite assisted oregano oil for controlled release and long-term bacterial inhibition
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614931/
https://www.ncbi.nlm.nih.gov/pubmed/34827262
http://dx.doi.org/10.3390/antibiotics10111324
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