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A Treasure of Bioactive Compounds from the Deep Sea

The deep-sea environment is a unique, challenging extreme habitat where species have had to adapt to the absence of light, low levels of oxygen, high pressure and little food. In order to survive such harsh conditions, these organisms have evolved different biochemical and physiological features tha...

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Detalles Bibliográficos
Autores principales: Saide, Assunta, Lauritano, Chiara, Ianora, Adrianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614969/
https://www.ncbi.nlm.nih.gov/pubmed/34829785
http://dx.doi.org/10.3390/biomedicines9111556
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author Saide, Assunta
Lauritano, Chiara
Ianora, Adrianna
author_facet Saide, Assunta
Lauritano, Chiara
Ianora, Adrianna
author_sort Saide, Assunta
collection PubMed
description The deep-sea environment is a unique, challenging extreme habitat where species have had to adapt to the absence of light, low levels of oxygen, high pressure and little food. In order to survive such harsh conditions, these organisms have evolved different biochemical and physiological features that often have no other equivalent in terrestrial habitats. Recent analyses have highlighted how the deep sea is one of the most diverse and species-rich habitats on the planet but less explored compared to more accessible sites. Because of their adaptation to this extreme environment, deep-sea species have the potential to produce novel secondary metabolites with potent biological activities. Recent advances in sampling and novel techniques in microorganism culturing and chemical isolation have promoted the discovery of bioactive agents from deep-sea organisms. However, reports of natural products derived from deep-sea species are still scarce, probably because of the difficulty in accessing deep-sea samples, sampling costs and the difficulty in culturing deep-sea organisms. In this review, we give an overview of the potential treasure represented by metabolites produced by deep marine species and their bioactivities for the treatment and prevention of various human pathologies.
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spelling pubmed-86149692021-11-26 A Treasure of Bioactive Compounds from the Deep Sea Saide, Assunta Lauritano, Chiara Ianora, Adrianna Biomedicines Review The deep-sea environment is a unique, challenging extreme habitat where species have had to adapt to the absence of light, low levels of oxygen, high pressure and little food. In order to survive such harsh conditions, these organisms have evolved different biochemical and physiological features that often have no other equivalent in terrestrial habitats. Recent analyses have highlighted how the deep sea is one of the most diverse and species-rich habitats on the planet but less explored compared to more accessible sites. Because of their adaptation to this extreme environment, deep-sea species have the potential to produce novel secondary metabolites with potent biological activities. Recent advances in sampling and novel techniques in microorganism culturing and chemical isolation have promoted the discovery of bioactive agents from deep-sea organisms. However, reports of natural products derived from deep-sea species are still scarce, probably because of the difficulty in accessing deep-sea samples, sampling costs and the difficulty in culturing deep-sea organisms. In this review, we give an overview of the potential treasure represented by metabolites produced by deep marine species and their bioactivities for the treatment and prevention of various human pathologies. MDPI 2021-10-28 /pmc/articles/PMC8614969/ /pubmed/34829785 http://dx.doi.org/10.3390/biomedicines9111556 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Saide, Assunta
Lauritano, Chiara
Ianora, Adrianna
A Treasure of Bioactive Compounds from the Deep Sea
title A Treasure of Bioactive Compounds from the Deep Sea
title_full A Treasure of Bioactive Compounds from the Deep Sea
title_fullStr A Treasure of Bioactive Compounds from the Deep Sea
title_full_unstemmed A Treasure of Bioactive Compounds from the Deep Sea
title_short A Treasure of Bioactive Compounds from the Deep Sea
title_sort treasure of bioactive compounds from the deep sea
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614969/
https://www.ncbi.nlm.nih.gov/pubmed/34829785
http://dx.doi.org/10.3390/biomedicines9111556
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