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Burden of Healthcare-Associated Infections in Sicily, Italy: Estimates from the Regional Point Prevalence Surveys 2016–2018

An assessment of the burden of healthcare-associated infections (HAIs) in terms of disability-adjusted life years (DALYs) is useful for comparing and ranking HAIs and to support infection prevention and control strategies. We estimated the burden of healthcare-associated pneumoniae (HAP), bloodstrea...

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Autores principales: Barchitta, Martina, Maugeri, Andrea, La Rosa, Maria Clara, La Mastra, Claudia, Murolo, Giuseppe, Corrao, Giovanni, Agodi, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614974/
https://www.ncbi.nlm.nih.gov/pubmed/34827298
http://dx.doi.org/10.3390/antibiotics10111360
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author Barchitta, Martina
Maugeri, Andrea
La Rosa, Maria Clara
La Mastra, Claudia
Murolo, Giuseppe
Corrao, Giovanni
Agodi, Antonella
author_facet Barchitta, Martina
Maugeri, Andrea
La Rosa, Maria Clara
La Mastra, Claudia
Murolo, Giuseppe
Corrao, Giovanni
Agodi, Antonella
author_sort Barchitta, Martina
collection PubMed
description An assessment of the burden of healthcare-associated infections (HAIs) in terms of disability-adjusted life years (DALYs) is useful for comparing and ranking HAIs and to support infection prevention and control strategies. We estimated the burden of healthcare-associated pneumoniae (HAP), bloodstream infection (HA BSI), urinary tract infection (HA UTI), and surgical site infection (SSI) in Sicily, Italy. We used data from 15,642 patients aged 45 years and above, identified during three repeated point prevalence surveys (PPSs) conducted from 2016 to 2018 according to the European Centre for Disease Prevention and Control protocol. The methodology of the Burden of Communicable Diseases in Europe project was employed. The selected HAIs accounted for 8424 DALYs (95% uncertainty interval (UI): 7394–9605) annually in Sicily, corresponding to 344 DALYs per 100,000 inhabitants aged 45 years and above (95% UI: 302–392). Notably, more than 60% of the burden was attributable to HAP, followed by HA BSI, SSI, and HA UTI. The latter had the lowest burden despite a relatively high incidence, whereas HA BSI generated a high burden even through a relatively low incidence. Differences between our estimates and those of European and Italian PPSs encourage the estimation of the burden of HAIs region by region.
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spelling pubmed-86149742021-11-26 Burden of Healthcare-Associated Infections in Sicily, Italy: Estimates from the Regional Point Prevalence Surveys 2016–2018 Barchitta, Martina Maugeri, Andrea La Rosa, Maria Clara La Mastra, Claudia Murolo, Giuseppe Corrao, Giovanni Agodi, Antonella Antibiotics (Basel) Article An assessment of the burden of healthcare-associated infections (HAIs) in terms of disability-adjusted life years (DALYs) is useful for comparing and ranking HAIs and to support infection prevention and control strategies. We estimated the burden of healthcare-associated pneumoniae (HAP), bloodstream infection (HA BSI), urinary tract infection (HA UTI), and surgical site infection (SSI) in Sicily, Italy. We used data from 15,642 patients aged 45 years and above, identified during three repeated point prevalence surveys (PPSs) conducted from 2016 to 2018 according to the European Centre for Disease Prevention and Control protocol. The methodology of the Burden of Communicable Diseases in Europe project was employed. The selected HAIs accounted for 8424 DALYs (95% uncertainty interval (UI): 7394–9605) annually in Sicily, corresponding to 344 DALYs per 100,000 inhabitants aged 45 years and above (95% UI: 302–392). Notably, more than 60% of the burden was attributable to HAP, followed by HA BSI, SSI, and HA UTI. The latter had the lowest burden despite a relatively high incidence, whereas HA BSI generated a high burden even through a relatively low incidence. Differences between our estimates and those of European and Italian PPSs encourage the estimation of the burden of HAIs region by region. MDPI 2021-11-08 /pmc/articles/PMC8614974/ /pubmed/34827298 http://dx.doi.org/10.3390/antibiotics10111360 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Barchitta, Martina
Maugeri, Andrea
La Rosa, Maria Clara
La Mastra, Claudia
Murolo, Giuseppe
Corrao, Giovanni
Agodi, Antonella
Burden of Healthcare-Associated Infections in Sicily, Italy: Estimates from the Regional Point Prevalence Surveys 2016–2018
title Burden of Healthcare-Associated Infections in Sicily, Italy: Estimates from the Regional Point Prevalence Surveys 2016–2018
title_full Burden of Healthcare-Associated Infections in Sicily, Italy: Estimates from the Regional Point Prevalence Surveys 2016–2018
title_fullStr Burden of Healthcare-Associated Infections in Sicily, Italy: Estimates from the Regional Point Prevalence Surveys 2016–2018
title_full_unstemmed Burden of Healthcare-Associated Infections in Sicily, Italy: Estimates from the Regional Point Prevalence Surveys 2016–2018
title_short Burden of Healthcare-Associated Infections in Sicily, Italy: Estimates from the Regional Point Prevalence Surveys 2016–2018
title_sort burden of healthcare-associated infections in sicily, italy: estimates from the regional point prevalence surveys 2016–2018
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8614974/
https://www.ncbi.nlm.nih.gov/pubmed/34827298
http://dx.doi.org/10.3390/antibiotics10111360
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