Chalcone-Derived Nrf2 Activator Protects Cognitive Function via Maintaining Neuronal Redox Status

NF-E2-related factor 2 (Nrf2), the key transcription regulator of phase II enzymes, has been considered beneficial for neuronal protection. We previously designed a novel chalcone analog, 1-(2,3,4-trimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-acrylketone (Tak), that could specifically activate Nrf2 i...

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Detalles Bibliográficos
Autores principales: Cui, Yuting, Xiong, Yue, Li, Hua, Zeng, Mengqi, Wang, Yan, Li, Yuan, Zou, Xuan, Lv, Weiqiang, Gao, Jing, Cao, Ruijun, Meng, Lingjie, Long, Jiangang, Liu, Jiankang, Feng, Zhihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615013/
https://www.ncbi.nlm.nih.gov/pubmed/34829682
http://dx.doi.org/10.3390/antiox10111811

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