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Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension

Previous studies have shown that plasma lipoprotein(a) (Lp(a)) plays an important role in the development of hypertensive organ damage. The aim of the present study was to investigate the relationship of Lp(a) with markers of arterial stiffening in hypertension. In 138 essential hypertensive patient...

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Autores principales: Brosolo, Gabriele, Da Porto, Andrea, Bulfone, Luca, Vacca, Antonio, Bertin, Nicole, Colussi, Gianluca, Cavarape, Alessandro, Sechi, Leonardo A., Catena, Cristiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615029/
https://www.ncbi.nlm.nih.gov/pubmed/34829739
http://dx.doi.org/10.3390/biomedicines9111510
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author Brosolo, Gabriele
Da Porto, Andrea
Bulfone, Luca
Vacca, Antonio
Bertin, Nicole
Colussi, Gianluca
Cavarape, Alessandro
Sechi, Leonardo A.
Catena, Cristiana
author_facet Brosolo, Gabriele
Da Porto, Andrea
Bulfone, Luca
Vacca, Antonio
Bertin, Nicole
Colussi, Gianluca
Cavarape, Alessandro
Sechi, Leonardo A.
Catena, Cristiana
author_sort Brosolo, Gabriele
collection PubMed
description Previous studies have shown that plasma lipoprotein(a) (Lp(a)) plays an important role in the development of hypertensive organ damage. The aim of the present study was to investigate the relationship of Lp(a) with markers of arterial stiffening in hypertension. In 138 essential hypertensive patients free of diabetes, renal failure and cardiovascular complications, we measured plasma lipids and assessed vascular stiffness through the use of pulse wave analysis and calculation of the brachial augmentation index (AIx), and measured the pulse wave velocity (PWV). Plasma Lp(a) levels were significantly and directly related to both AIx (r = 0.490; p < 0.001) and PWV (r = 0.212; p = 0.013). Multiple regression analysis showed that AIx was independently correlated with age, C-reactive protein, and plasma Lp(a) (beta 0.326; p < 0.001), while PWV was independently and directly correlated with age, and inversely with HDL, but not with plasma Lp(a). Logistic regression indicated that plasma Lp(a) could predict an AIx value above the median for the distribution (p = 0.026). Thus, in a highly selective group of patients with hypertension, plasma Lp(a) levels were significantly and directly related to markers of vascular stiffening. Because of the relevance of vascular stiffening to cardiovascular risk, the reduction of Lp(a) levels might be beneficial for cardiovascular protection in patients with hypertension.
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spelling pubmed-86150292021-11-26 Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension Brosolo, Gabriele Da Porto, Andrea Bulfone, Luca Vacca, Antonio Bertin, Nicole Colussi, Gianluca Cavarape, Alessandro Sechi, Leonardo A. Catena, Cristiana Biomedicines Article Previous studies have shown that plasma lipoprotein(a) (Lp(a)) plays an important role in the development of hypertensive organ damage. The aim of the present study was to investigate the relationship of Lp(a) with markers of arterial stiffening in hypertension. In 138 essential hypertensive patients free of diabetes, renal failure and cardiovascular complications, we measured plasma lipids and assessed vascular stiffness through the use of pulse wave analysis and calculation of the brachial augmentation index (AIx), and measured the pulse wave velocity (PWV). Plasma Lp(a) levels were significantly and directly related to both AIx (r = 0.490; p < 0.001) and PWV (r = 0.212; p = 0.013). Multiple regression analysis showed that AIx was independently correlated with age, C-reactive protein, and plasma Lp(a) (beta 0.326; p < 0.001), while PWV was independently and directly correlated with age, and inversely with HDL, but not with plasma Lp(a). Logistic regression indicated that plasma Lp(a) could predict an AIx value above the median for the distribution (p = 0.026). Thus, in a highly selective group of patients with hypertension, plasma Lp(a) levels were significantly and directly related to markers of vascular stiffening. Because of the relevance of vascular stiffening to cardiovascular risk, the reduction of Lp(a) levels might be beneficial for cardiovascular protection in patients with hypertension. MDPI 2021-10-20 /pmc/articles/PMC8615029/ /pubmed/34829739 http://dx.doi.org/10.3390/biomedicines9111510 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Brosolo, Gabriele
Da Porto, Andrea
Bulfone, Luca
Vacca, Antonio
Bertin, Nicole
Colussi, Gianluca
Cavarape, Alessandro
Sechi, Leonardo A.
Catena, Cristiana
Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension
title Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension
title_full Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension
title_fullStr Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension
title_full_unstemmed Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension
title_short Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension
title_sort plasma lipoprotein(a) levels as determinants of arterial stiffening in hypertension
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615029/
https://www.ncbi.nlm.nih.gov/pubmed/34829739
http://dx.doi.org/10.3390/biomedicines9111510
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