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Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension
Previous studies have shown that plasma lipoprotein(a) (Lp(a)) plays an important role in the development of hypertensive organ damage. The aim of the present study was to investigate the relationship of Lp(a) with markers of arterial stiffening in hypertension. In 138 essential hypertensive patient...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615029/ https://www.ncbi.nlm.nih.gov/pubmed/34829739 http://dx.doi.org/10.3390/biomedicines9111510 |
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author | Brosolo, Gabriele Da Porto, Andrea Bulfone, Luca Vacca, Antonio Bertin, Nicole Colussi, Gianluca Cavarape, Alessandro Sechi, Leonardo A. Catena, Cristiana |
author_facet | Brosolo, Gabriele Da Porto, Andrea Bulfone, Luca Vacca, Antonio Bertin, Nicole Colussi, Gianluca Cavarape, Alessandro Sechi, Leonardo A. Catena, Cristiana |
author_sort | Brosolo, Gabriele |
collection | PubMed |
description | Previous studies have shown that plasma lipoprotein(a) (Lp(a)) plays an important role in the development of hypertensive organ damage. The aim of the present study was to investigate the relationship of Lp(a) with markers of arterial stiffening in hypertension. In 138 essential hypertensive patients free of diabetes, renal failure and cardiovascular complications, we measured plasma lipids and assessed vascular stiffness through the use of pulse wave analysis and calculation of the brachial augmentation index (AIx), and measured the pulse wave velocity (PWV). Plasma Lp(a) levels were significantly and directly related to both AIx (r = 0.490; p < 0.001) and PWV (r = 0.212; p = 0.013). Multiple regression analysis showed that AIx was independently correlated with age, C-reactive protein, and plasma Lp(a) (beta 0.326; p < 0.001), while PWV was independently and directly correlated with age, and inversely with HDL, but not with plasma Lp(a). Logistic regression indicated that plasma Lp(a) could predict an AIx value above the median for the distribution (p = 0.026). Thus, in a highly selective group of patients with hypertension, plasma Lp(a) levels were significantly and directly related to markers of vascular stiffening. Because of the relevance of vascular stiffening to cardiovascular risk, the reduction of Lp(a) levels might be beneficial for cardiovascular protection in patients with hypertension. |
format | Online Article Text |
id | pubmed-8615029 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86150292021-11-26 Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension Brosolo, Gabriele Da Porto, Andrea Bulfone, Luca Vacca, Antonio Bertin, Nicole Colussi, Gianluca Cavarape, Alessandro Sechi, Leonardo A. Catena, Cristiana Biomedicines Article Previous studies have shown that plasma lipoprotein(a) (Lp(a)) plays an important role in the development of hypertensive organ damage. The aim of the present study was to investigate the relationship of Lp(a) with markers of arterial stiffening in hypertension. In 138 essential hypertensive patients free of diabetes, renal failure and cardiovascular complications, we measured plasma lipids and assessed vascular stiffness through the use of pulse wave analysis and calculation of the brachial augmentation index (AIx), and measured the pulse wave velocity (PWV). Plasma Lp(a) levels were significantly and directly related to both AIx (r = 0.490; p < 0.001) and PWV (r = 0.212; p = 0.013). Multiple regression analysis showed that AIx was independently correlated with age, C-reactive protein, and plasma Lp(a) (beta 0.326; p < 0.001), while PWV was independently and directly correlated with age, and inversely with HDL, but not with plasma Lp(a). Logistic regression indicated that plasma Lp(a) could predict an AIx value above the median for the distribution (p = 0.026). Thus, in a highly selective group of patients with hypertension, plasma Lp(a) levels were significantly and directly related to markers of vascular stiffening. Because of the relevance of vascular stiffening to cardiovascular risk, the reduction of Lp(a) levels might be beneficial for cardiovascular protection in patients with hypertension. MDPI 2021-10-20 /pmc/articles/PMC8615029/ /pubmed/34829739 http://dx.doi.org/10.3390/biomedicines9111510 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Brosolo, Gabriele Da Porto, Andrea Bulfone, Luca Vacca, Antonio Bertin, Nicole Colussi, Gianluca Cavarape, Alessandro Sechi, Leonardo A. Catena, Cristiana Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension |
title | Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension |
title_full | Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension |
title_fullStr | Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension |
title_full_unstemmed | Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension |
title_short | Plasma Lipoprotein(a) Levels as Determinants of Arterial Stiffening in Hypertension |
title_sort | plasma lipoprotein(a) levels as determinants of arterial stiffening in hypertension |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615029/ https://www.ncbi.nlm.nih.gov/pubmed/34829739 http://dx.doi.org/10.3390/biomedicines9111510 |
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