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Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock

(1) Background: It is critical to administer antibiotics and fluid bolus within 1 h of recognizing sepsis in pediatric patients. This study aimed to identify the predictor of the successful completion of a 1-h sepsis bundle for infants with suspected sepsis. (2) Methods: This is an observational stu...

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Autores principales: Nomura, Osamu, Ihara, Takateru, Morikawa, Yoshihiko, Sakakibara, Hiroshi, Horikoshi, Yuho, Inoue, Nobuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615069/
https://www.ncbi.nlm.nih.gov/pubmed/34827352
http://dx.doi.org/10.3390/antibiotics10111414
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author Nomura, Osamu
Ihara, Takateru
Morikawa, Yoshihiko
Sakakibara, Hiroshi
Horikoshi, Yuho
Inoue, Nobuaki
author_facet Nomura, Osamu
Ihara, Takateru
Morikawa, Yoshihiko
Sakakibara, Hiroshi
Horikoshi, Yuho
Inoue, Nobuaki
author_sort Nomura, Osamu
collection PubMed
description (1) Background: It is critical to administer antibiotics and fluid bolus within 1 h of recognizing sepsis in pediatric patients. This study aimed to identify the predictor of the successful completion of a 1-h sepsis bundle for infants with suspected sepsis. (2) Methods: This is an observational study using a prospective registry including febrile young infants (aged < 90 days) who visited a pediatric emergency department with a core body temperature of 38.0 °C or higher and 36.0 °C or lower. Univariate and logistic regression analyses were conducted to determine the predictor (s) of successful sepsis bundle completion. (3) Results: Of the 323 registered patients, 118 patients with suspected sepsis were analyzed, and 38 patients (32.2%) received a bundle-compliant treatment. Among potential variables, such as age, sex, and vital sign parameters, the logistic regression analysis showed that heart rate (odds ratio: OR 1.02; 95% confidence interval: 1.00–1.04) is a significant predictor of the completion of a 1-h sepsis bundle. (4) Conclusions: We found that tachycardia facilitated the sepsis recognition and promoted the successful completion of a 1-h sepsis bundle for young infants with suspected septic shock and a possible indicator for improving the quality of the team-based sepsis management.
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spelling pubmed-86150692021-11-26 Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock Nomura, Osamu Ihara, Takateru Morikawa, Yoshihiko Sakakibara, Hiroshi Horikoshi, Yuho Inoue, Nobuaki Antibiotics (Basel) Article (1) Background: It is critical to administer antibiotics and fluid bolus within 1 h of recognizing sepsis in pediatric patients. This study aimed to identify the predictor of the successful completion of a 1-h sepsis bundle for infants with suspected sepsis. (2) Methods: This is an observational study using a prospective registry including febrile young infants (aged < 90 days) who visited a pediatric emergency department with a core body temperature of 38.0 °C or higher and 36.0 °C or lower. Univariate and logistic regression analyses were conducted to determine the predictor (s) of successful sepsis bundle completion. (3) Results: Of the 323 registered patients, 118 patients with suspected sepsis were analyzed, and 38 patients (32.2%) received a bundle-compliant treatment. Among potential variables, such as age, sex, and vital sign parameters, the logistic regression analysis showed that heart rate (odds ratio: OR 1.02; 95% confidence interval: 1.00–1.04) is a significant predictor of the completion of a 1-h sepsis bundle. (4) Conclusions: We found that tachycardia facilitated the sepsis recognition and promoted the successful completion of a 1-h sepsis bundle for young infants with suspected septic shock and a possible indicator for improving the quality of the team-based sepsis management. MDPI 2021-11-19 /pmc/articles/PMC8615069/ /pubmed/34827352 http://dx.doi.org/10.3390/antibiotics10111414 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nomura, Osamu
Ihara, Takateru
Morikawa, Yoshihiko
Sakakibara, Hiroshi
Horikoshi, Yuho
Inoue, Nobuaki
Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock
title Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock
title_full Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock
title_fullStr Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock
title_full_unstemmed Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock
title_short Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock
title_sort predictor of early administration of antibiotics and a volume resuscitation for young infants with septic shock
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615069/
https://www.ncbi.nlm.nih.gov/pubmed/34827352
http://dx.doi.org/10.3390/antibiotics10111414
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