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Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock
(1) Background: It is critical to administer antibiotics and fluid bolus within 1 h of recognizing sepsis in pediatric patients. This study aimed to identify the predictor of the successful completion of a 1-h sepsis bundle for infants with suspected sepsis. (2) Methods: This is an observational stu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615069/ https://www.ncbi.nlm.nih.gov/pubmed/34827352 http://dx.doi.org/10.3390/antibiotics10111414 |
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author | Nomura, Osamu Ihara, Takateru Morikawa, Yoshihiko Sakakibara, Hiroshi Horikoshi, Yuho Inoue, Nobuaki |
author_facet | Nomura, Osamu Ihara, Takateru Morikawa, Yoshihiko Sakakibara, Hiroshi Horikoshi, Yuho Inoue, Nobuaki |
author_sort | Nomura, Osamu |
collection | PubMed |
description | (1) Background: It is critical to administer antibiotics and fluid bolus within 1 h of recognizing sepsis in pediatric patients. This study aimed to identify the predictor of the successful completion of a 1-h sepsis bundle for infants with suspected sepsis. (2) Methods: This is an observational study using a prospective registry including febrile young infants (aged < 90 days) who visited a pediatric emergency department with a core body temperature of 38.0 °C or higher and 36.0 °C or lower. Univariate and logistic regression analyses were conducted to determine the predictor (s) of successful sepsis bundle completion. (3) Results: Of the 323 registered patients, 118 patients with suspected sepsis were analyzed, and 38 patients (32.2%) received a bundle-compliant treatment. Among potential variables, such as age, sex, and vital sign parameters, the logistic regression analysis showed that heart rate (odds ratio: OR 1.02; 95% confidence interval: 1.00–1.04) is a significant predictor of the completion of a 1-h sepsis bundle. (4) Conclusions: We found that tachycardia facilitated the sepsis recognition and promoted the successful completion of a 1-h sepsis bundle for young infants with suspected septic shock and a possible indicator for improving the quality of the team-based sepsis management. |
format | Online Article Text |
id | pubmed-8615069 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86150692021-11-26 Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock Nomura, Osamu Ihara, Takateru Morikawa, Yoshihiko Sakakibara, Hiroshi Horikoshi, Yuho Inoue, Nobuaki Antibiotics (Basel) Article (1) Background: It is critical to administer antibiotics and fluid bolus within 1 h of recognizing sepsis in pediatric patients. This study aimed to identify the predictor of the successful completion of a 1-h sepsis bundle for infants with suspected sepsis. (2) Methods: This is an observational study using a prospective registry including febrile young infants (aged < 90 days) who visited a pediatric emergency department with a core body temperature of 38.0 °C or higher and 36.0 °C or lower. Univariate and logistic regression analyses were conducted to determine the predictor (s) of successful sepsis bundle completion. (3) Results: Of the 323 registered patients, 118 patients with suspected sepsis were analyzed, and 38 patients (32.2%) received a bundle-compliant treatment. Among potential variables, such as age, sex, and vital sign parameters, the logistic regression analysis showed that heart rate (odds ratio: OR 1.02; 95% confidence interval: 1.00–1.04) is a significant predictor of the completion of a 1-h sepsis bundle. (4) Conclusions: We found that tachycardia facilitated the sepsis recognition and promoted the successful completion of a 1-h sepsis bundle for young infants with suspected septic shock and a possible indicator for improving the quality of the team-based sepsis management. MDPI 2021-11-19 /pmc/articles/PMC8615069/ /pubmed/34827352 http://dx.doi.org/10.3390/antibiotics10111414 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nomura, Osamu Ihara, Takateru Morikawa, Yoshihiko Sakakibara, Hiroshi Horikoshi, Yuho Inoue, Nobuaki Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock |
title | Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock |
title_full | Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock |
title_fullStr | Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock |
title_full_unstemmed | Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock |
title_short | Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock |
title_sort | predictor of early administration of antibiotics and a volume resuscitation for young infants with septic shock |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615069/ https://www.ncbi.nlm.nih.gov/pubmed/34827352 http://dx.doi.org/10.3390/antibiotics10111414 |
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