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Glutathione Peroxidase in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis

Chronic obstructive pulmonary disease (COPD) is a progressive disease that is characterized by a state of persistent inflammation and oxidative stress. The presence of oxidative stress in COPD is the result of an imbalance between pro-oxidant and antioxidant mechanisms. The aim of this review was to...

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Autores principales: Zinellu, Elisabetta, Zinellu, Angelo, Pau, Maria Carmina, Piras, Barbara, Fois, Alessandro G., Mellino, Sabrina, Carru, Ciriaco, Mangoni, Arduino A., Pirina, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615188/
https://www.ncbi.nlm.nih.gov/pubmed/34829616
http://dx.doi.org/10.3390/antiox10111745
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author Zinellu, Elisabetta
Zinellu, Angelo
Pau, Maria Carmina
Piras, Barbara
Fois, Alessandro G.
Mellino, Sabrina
Carru, Ciriaco
Mangoni, Arduino A.
Pirina, Pietro
author_facet Zinellu, Elisabetta
Zinellu, Angelo
Pau, Maria Carmina
Piras, Barbara
Fois, Alessandro G.
Mellino, Sabrina
Carru, Ciriaco
Mangoni, Arduino A.
Pirina, Pietro
author_sort Zinellu, Elisabetta
collection PubMed
description Chronic obstructive pulmonary disease (COPD) is a progressive disease that is characterized by a state of persistent inflammation and oxidative stress. The presence of oxidative stress in COPD is the result of an imbalance between pro-oxidant and antioxidant mechanisms. The aim of this review was to investigate a possible association between glutathione peroxidase (GPx), a key component of antioxidant defense mechanisms, and COPD. A systematic search for relevant studies was conducted in the electronic databases PubMed, Web of Science, Scopus, and Google Scholar, from inception to June 2021. Standardized mean differences (SMDs) were used to express the differences in GPx concentrations between COPD patients and non-COPD subjects. Twenty-four studies were identified. In 15 studies assessing whole blood/erythrocytes (GPx isoform 1), the pooled results showed that GPx concentrations were significantly lower in patients with COPD (SMD = −1.91, 95% CI −2.55 to −1.28, p < 0.001; moderate certainty of evidence). By contrast, in 10 studies assessing serum/plasma (GPx isoform 3), the pooled results showed that GPx concentrations were not significantly different between the two groups (very low certainty of evidence). The concentration of GPx-1, but not GPx-3, is significantly lower in COPD patients, suggesting an impairment of antioxidant defense mechanisms in this group.
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spelling pubmed-86151882021-11-26 Glutathione Peroxidase in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis Zinellu, Elisabetta Zinellu, Angelo Pau, Maria Carmina Piras, Barbara Fois, Alessandro G. Mellino, Sabrina Carru, Ciriaco Mangoni, Arduino A. Pirina, Pietro Antioxidants (Basel) Systematic Review Chronic obstructive pulmonary disease (COPD) is a progressive disease that is characterized by a state of persistent inflammation and oxidative stress. The presence of oxidative stress in COPD is the result of an imbalance between pro-oxidant and antioxidant mechanisms. The aim of this review was to investigate a possible association between glutathione peroxidase (GPx), a key component of antioxidant defense mechanisms, and COPD. A systematic search for relevant studies was conducted in the electronic databases PubMed, Web of Science, Scopus, and Google Scholar, from inception to June 2021. Standardized mean differences (SMDs) were used to express the differences in GPx concentrations between COPD patients and non-COPD subjects. Twenty-four studies were identified. In 15 studies assessing whole blood/erythrocytes (GPx isoform 1), the pooled results showed that GPx concentrations were significantly lower in patients with COPD (SMD = −1.91, 95% CI −2.55 to −1.28, p < 0.001; moderate certainty of evidence). By contrast, in 10 studies assessing serum/plasma (GPx isoform 3), the pooled results showed that GPx concentrations were not significantly different between the two groups (very low certainty of evidence). The concentration of GPx-1, but not GPx-3, is significantly lower in COPD patients, suggesting an impairment of antioxidant defense mechanisms in this group. MDPI 2021-10-30 /pmc/articles/PMC8615188/ /pubmed/34829616 http://dx.doi.org/10.3390/antiox10111745 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Zinellu, Elisabetta
Zinellu, Angelo
Pau, Maria Carmina
Piras, Barbara
Fois, Alessandro G.
Mellino, Sabrina
Carru, Ciriaco
Mangoni, Arduino A.
Pirina, Pietro
Glutathione Peroxidase in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis
title Glutathione Peroxidase in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis
title_full Glutathione Peroxidase in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis
title_fullStr Glutathione Peroxidase in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis
title_full_unstemmed Glutathione Peroxidase in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis
title_short Glutathione Peroxidase in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis
title_sort glutathione peroxidase in stable chronic obstructive pulmonary disease: a systematic review and meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615188/
https://www.ncbi.nlm.nih.gov/pubmed/34829616
http://dx.doi.org/10.3390/antiox10111745
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