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Recent Advances in Natural Materials for Corneal Tissue Engineering

Given the incidence of corneal dysfunctions and diseases worldwide and the limited availability of healthy, human donors, investigators are working to generate engineered cellular and acellular therapeutic approaches as alternatives to corneal transplants from human cadavers. These engineered strate...

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Autores principales: Jameson, Julie F., Pacheco, Marisa O., Nguyen, Henry H., Phelps, Edward A., Stoppel, Whitney L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615221/
https://www.ncbi.nlm.nih.gov/pubmed/34821727
http://dx.doi.org/10.3390/bioengineering8110161
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author Jameson, Julie F.
Pacheco, Marisa O.
Nguyen, Henry H.
Phelps, Edward A.
Stoppel, Whitney L.
author_facet Jameson, Julie F.
Pacheco, Marisa O.
Nguyen, Henry H.
Phelps, Edward A.
Stoppel, Whitney L.
author_sort Jameson, Julie F.
collection PubMed
description Given the incidence of corneal dysfunctions and diseases worldwide and the limited availability of healthy, human donors, investigators are working to generate engineered cellular and acellular therapeutic approaches as alternatives to corneal transplants from human cadavers. These engineered strategies aim to address existing complications with human corneal transplants, including graft rejection, infection, and complications resulting from surgical methodologies. The main goals of these research endeavors are to (1) determine ideal mechanical properties, (2) devise methodologies to improve the efficacy of engineered corneal grafts and cell-based therapies, and (3) optimize transplantation of engineered tissue structures in the eye. Thus, recent innovations have sought to address these challenges through both in vitro and in vivo studies. This review covers recent work aimed at evaluating engineered materials, potential therapeutic cells, and the resulting cell-material interactions that lead to optimal corneal graft properties. Furthermore, we discuss promising strategies in corneal tissue engineering techniques and in vivo studies in animal models.
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spelling pubmed-86152212021-11-26 Recent Advances in Natural Materials for Corneal Tissue Engineering Jameson, Julie F. Pacheco, Marisa O. Nguyen, Henry H. Phelps, Edward A. Stoppel, Whitney L. Bioengineering (Basel) Review Given the incidence of corneal dysfunctions and diseases worldwide and the limited availability of healthy, human donors, investigators are working to generate engineered cellular and acellular therapeutic approaches as alternatives to corneal transplants from human cadavers. These engineered strategies aim to address existing complications with human corneal transplants, including graft rejection, infection, and complications resulting from surgical methodologies. The main goals of these research endeavors are to (1) determine ideal mechanical properties, (2) devise methodologies to improve the efficacy of engineered corneal grafts and cell-based therapies, and (3) optimize transplantation of engineered tissue structures in the eye. Thus, recent innovations have sought to address these challenges through both in vitro and in vivo studies. This review covers recent work aimed at evaluating engineered materials, potential therapeutic cells, and the resulting cell-material interactions that lead to optimal corneal graft properties. Furthermore, we discuss promising strategies in corneal tissue engineering techniques and in vivo studies in animal models. MDPI 2021-10-26 /pmc/articles/PMC8615221/ /pubmed/34821727 http://dx.doi.org/10.3390/bioengineering8110161 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jameson, Julie F.
Pacheco, Marisa O.
Nguyen, Henry H.
Phelps, Edward A.
Stoppel, Whitney L.
Recent Advances in Natural Materials for Corneal Tissue Engineering
title Recent Advances in Natural Materials for Corneal Tissue Engineering
title_full Recent Advances in Natural Materials for Corneal Tissue Engineering
title_fullStr Recent Advances in Natural Materials for Corneal Tissue Engineering
title_full_unstemmed Recent Advances in Natural Materials for Corneal Tissue Engineering
title_short Recent Advances in Natural Materials for Corneal Tissue Engineering
title_sort recent advances in natural materials for corneal tissue engineering
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615221/
https://www.ncbi.nlm.nih.gov/pubmed/34821727
http://dx.doi.org/10.3390/bioengineering8110161
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