Cargando…
Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights
Natural bioactive compounds derived from plant-based products are known for their biological immunomodulatory activities. They possess systemic pleiotropic effects, minimal side effects, and very low toxicities. Plant-based bioactive compounds have tremendous potential as natural therapeutic entitie...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615223/ https://www.ncbi.nlm.nih.gov/pubmed/34829751 http://dx.doi.org/10.3390/biomedicines9111522 |
_version_ | 1784604052973158400 |
---|---|
author | Gangwar, Vani Garg, Amar Lomore, Karan Korla, Kalyani Bhat, Shruthi S. Rao, Raghavendra P. Rafiq, Mohamed Kumawath, Rajesh Uddagiri, Babu V. Kareenhalli, Venkatesh V. |
author_facet | Gangwar, Vani Garg, Amar Lomore, Karan Korla, Kalyani Bhat, Shruthi S. Rao, Raghavendra P. Rafiq, Mohamed Kumawath, Rajesh Uddagiri, Babu V. Kareenhalli, Venkatesh V. |
author_sort | Gangwar, Vani |
collection | PubMed |
description | Natural bioactive compounds derived from plant-based products are known for their biological immunomodulatory activities. They possess systemic pleiotropic effects, minimal side effects, and very low toxicities. Plant-based bioactive compounds have tremendous potential as natural therapeutic entities against various disease conditions and act as anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-viral, anti-tumour, anti-allergic, neuroprotective, and cardioprotective agents. A herbal formulation extract including five biologically active compounds: Apigenin, Quercetin, Betulinic acid, Oleanolic acid, and β-Sitosterol can impart several immunomodulatory effects. In this review, we systematically present the impact of these compounds on important molecular signaling pathways, including inflammation, immunity, redox metabolism, neuroinflammation, neutropenia, cell growth, apoptosis, and cell cycle. The review corroborates the beneficial effect of these compounds and shows considerable potential to be used as a safer, more cost-effective treatment for several diseases by affecting the major nodal points of various stimulatory pathways. |
format | Online Article Text |
id | pubmed-8615223 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86152232021-11-26 Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights Gangwar, Vani Garg, Amar Lomore, Karan Korla, Kalyani Bhat, Shruthi S. Rao, Raghavendra P. Rafiq, Mohamed Kumawath, Rajesh Uddagiri, Babu V. Kareenhalli, Venkatesh V. Biomedicines Review Natural bioactive compounds derived from plant-based products are known for their biological immunomodulatory activities. They possess systemic pleiotropic effects, minimal side effects, and very low toxicities. Plant-based bioactive compounds have tremendous potential as natural therapeutic entities against various disease conditions and act as anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-viral, anti-tumour, anti-allergic, neuroprotective, and cardioprotective agents. A herbal formulation extract including five biologically active compounds: Apigenin, Quercetin, Betulinic acid, Oleanolic acid, and β-Sitosterol can impart several immunomodulatory effects. In this review, we systematically present the impact of these compounds on important molecular signaling pathways, including inflammation, immunity, redox metabolism, neuroinflammation, neutropenia, cell growth, apoptosis, and cell cycle. The review corroborates the beneficial effect of these compounds and shows considerable potential to be used as a safer, more cost-effective treatment for several diseases by affecting the major nodal points of various stimulatory pathways. MDPI 2021-10-22 /pmc/articles/PMC8615223/ /pubmed/34829751 http://dx.doi.org/10.3390/biomedicines9111522 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gangwar, Vani Garg, Amar Lomore, Karan Korla, Kalyani Bhat, Shruthi S. Rao, Raghavendra P. Rafiq, Mohamed Kumawath, Rajesh Uddagiri, Babu V. Kareenhalli, Venkatesh V. Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights |
title | Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights |
title_full | Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights |
title_fullStr | Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights |
title_full_unstemmed | Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights |
title_short | Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights |
title_sort | immunomodulatory effects of a concoction of natural bioactive compounds—mechanistic insights |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615223/ https://www.ncbi.nlm.nih.gov/pubmed/34829751 http://dx.doi.org/10.3390/biomedicines9111522 |
work_keys_str_mv | AT gangwarvani immunomodulatoryeffectsofaconcoctionofnaturalbioactivecompoundsmechanisticinsights AT gargamar immunomodulatoryeffectsofaconcoctionofnaturalbioactivecompoundsmechanisticinsights AT lomorekaran immunomodulatoryeffectsofaconcoctionofnaturalbioactivecompoundsmechanisticinsights AT korlakalyani immunomodulatoryeffectsofaconcoctionofnaturalbioactivecompoundsmechanisticinsights AT bhatshruthis immunomodulatoryeffectsofaconcoctionofnaturalbioactivecompoundsmechanisticinsights AT raoraghavendrap immunomodulatoryeffectsofaconcoctionofnaturalbioactivecompoundsmechanisticinsights AT rafiqmohamed immunomodulatoryeffectsofaconcoctionofnaturalbioactivecompoundsmechanisticinsights AT kumawathrajesh immunomodulatoryeffectsofaconcoctionofnaturalbioactivecompoundsmechanisticinsights AT uddagiribabuv immunomodulatoryeffectsofaconcoctionofnaturalbioactivecompoundsmechanisticinsights AT kareenhallivenkateshv immunomodulatoryeffectsofaconcoctionofnaturalbioactivecompoundsmechanisticinsights |