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Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study

We examined the correlation between previous antibiotic exposure and COVID-19 severity using a population-based observational matched cohort study with patient level data obtained for more than 5.8 million people registered in SIDIAP in Catalonia, Spain. We included all patients newly diagnosed with...

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Autores principales: Llor, Carl, Ouchi, Dan, Giner-Soriano, Maria, García-Sangenís, Ana, Bjerrum, Lars, Morros, Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615228/
https://www.ncbi.nlm.nih.gov/pubmed/34827302
http://dx.doi.org/10.3390/antibiotics10111364
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author Llor, Carl
Ouchi, Dan
Giner-Soriano, Maria
García-Sangenís, Ana
Bjerrum, Lars
Morros, Rosa
author_facet Llor, Carl
Ouchi, Dan
Giner-Soriano, Maria
García-Sangenís, Ana
Bjerrum, Lars
Morros, Rosa
author_sort Llor, Carl
collection PubMed
description We examined the correlation between previous antibiotic exposure and COVID-19 severity using a population-based observational matched cohort study with patient level data obtained for more than 5.8 million people registered in SIDIAP in Catalonia, Spain. We included all patients newly diagnosed with COVID-19 from March to June 2020 and identified all their antibiotic prescriptions in the previous two years. We used a composite severity endpoint, including pneumonia, hospital admission and death due to COVID-19. We examined the influence of high antibiotic exposure (>4 regimens), exposure to highest priority critically important antimicrobials (HPCIA) and recent exposure. Potential confounders were adjusted by logistic regression. A total of 280,679 patients were diagnosed with COVID-19, 146,656 of whom were exposed to at least one antibiotic course (52.3%) during the preceding two years. A total of 25,222 presented severe COVID-19 infection (9%), and the risk of severity was highest among those exposed to antibiotics (OR 1.12; 95% CI: 1.04–1.21). Among all individuals exposed to antibiotics, high, recent and exposure to HPCIAs were correlated with increased COVID severity (OR 1.19; 95% CI: 1.14–1.26; 1.41; 95% CI: 1.36–1.46; and 1.35; 95% CI: 1.30–1.40, respectively). Our findings confirm a significant correlation between previous antibiotic exposure and increased severity of COVID-19 disease.
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spelling pubmed-86152282021-11-26 Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study Llor, Carl Ouchi, Dan Giner-Soriano, Maria García-Sangenís, Ana Bjerrum, Lars Morros, Rosa Antibiotics (Basel) Article We examined the correlation between previous antibiotic exposure and COVID-19 severity using a population-based observational matched cohort study with patient level data obtained for more than 5.8 million people registered in SIDIAP in Catalonia, Spain. We included all patients newly diagnosed with COVID-19 from March to June 2020 and identified all their antibiotic prescriptions in the previous two years. We used a composite severity endpoint, including pneumonia, hospital admission and death due to COVID-19. We examined the influence of high antibiotic exposure (>4 regimens), exposure to highest priority critically important antimicrobials (HPCIA) and recent exposure. Potential confounders were adjusted by logistic regression. A total of 280,679 patients were diagnosed with COVID-19, 146,656 of whom were exposed to at least one antibiotic course (52.3%) during the preceding two years. A total of 25,222 presented severe COVID-19 infection (9%), and the risk of severity was highest among those exposed to antibiotics (OR 1.12; 95% CI: 1.04–1.21). Among all individuals exposed to antibiotics, high, recent and exposure to HPCIAs were correlated with increased COVID severity (OR 1.19; 95% CI: 1.14–1.26; 1.41; 95% CI: 1.36–1.46; and 1.35; 95% CI: 1.30–1.40, respectively). Our findings confirm a significant correlation between previous antibiotic exposure and increased severity of COVID-19 disease. MDPI 2021-11-08 /pmc/articles/PMC8615228/ /pubmed/34827302 http://dx.doi.org/10.3390/antibiotics10111364 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Llor, Carl
Ouchi, Dan
Giner-Soriano, Maria
García-Sangenís, Ana
Bjerrum, Lars
Morros, Rosa
Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study
title Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study
title_full Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study
title_fullStr Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study
title_full_unstemmed Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study
title_short Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study
title_sort correlation between previous antibiotic exposure and covid-19 severity. a population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615228/
https://www.ncbi.nlm.nih.gov/pubmed/34827302
http://dx.doi.org/10.3390/antibiotics10111364
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