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Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study
We examined the correlation between previous antibiotic exposure and COVID-19 severity using a population-based observational matched cohort study with patient level data obtained for more than 5.8 million people registered in SIDIAP in Catalonia, Spain. We included all patients newly diagnosed with...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615228/ https://www.ncbi.nlm.nih.gov/pubmed/34827302 http://dx.doi.org/10.3390/antibiotics10111364 |
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author | Llor, Carl Ouchi, Dan Giner-Soriano, Maria García-Sangenís, Ana Bjerrum, Lars Morros, Rosa |
author_facet | Llor, Carl Ouchi, Dan Giner-Soriano, Maria García-Sangenís, Ana Bjerrum, Lars Morros, Rosa |
author_sort | Llor, Carl |
collection | PubMed |
description | We examined the correlation between previous antibiotic exposure and COVID-19 severity using a population-based observational matched cohort study with patient level data obtained for more than 5.8 million people registered in SIDIAP in Catalonia, Spain. We included all patients newly diagnosed with COVID-19 from March to June 2020 and identified all their antibiotic prescriptions in the previous two years. We used a composite severity endpoint, including pneumonia, hospital admission and death due to COVID-19. We examined the influence of high antibiotic exposure (>4 regimens), exposure to highest priority critically important antimicrobials (HPCIA) and recent exposure. Potential confounders were adjusted by logistic regression. A total of 280,679 patients were diagnosed with COVID-19, 146,656 of whom were exposed to at least one antibiotic course (52.3%) during the preceding two years. A total of 25,222 presented severe COVID-19 infection (9%), and the risk of severity was highest among those exposed to antibiotics (OR 1.12; 95% CI: 1.04–1.21). Among all individuals exposed to antibiotics, high, recent and exposure to HPCIAs were correlated with increased COVID severity (OR 1.19; 95% CI: 1.14–1.26; 1.41; 95% CI: 1.36–1.46; and 1.35; 95% CI: 1.30–1.40, respectively). Our findings confirm a significant correlation between previous antibiotic exposure and increased severity of COVID-19 disease. |
format | Online Article Text |
id | pubmed-8615228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86152282021-11-26 Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study Llor, Carl Ouchi, Dan Giner-Soriano, Maria García-Sangenís, Ana Bjerrum, Lars Morros, Rosa Antibiotics (Basel) Article We examined the correlation between previous antibiotic exposure and COVID-19 severity using a population-based observational matched cohort study with patient level data obtained for more than 5.8 million people registered in SIDIAP in Catalonia, Spain. We included all patients newly diagnosed with COVID-19 from March to June 2020 and identified all their antibiotic prescriptions in the previous two years. We used a composite severity endpoint, including pneumonia, hospital admission and death due to COVID-19. We examined the influence of high antibiotic exposure (>4 regimens), exposure to highest priority critically important antimicrobials (HPCIA) and recent exposure. Potential confounders were adjusted by logistic regression. A total of 280,679 patients were diagnosed with COVID-19, 146,656 of whom were exposed to at least one antibiotic course (52.3%) during the preceding two years. A total of 25,222 presented severe COVID-19 infection (9%), and the risk of severity was highest among those exposed to antibiotics (OR 1.12; 95% CI: 1.04–1.21). Among all individuals exposed to antibiotics, high, recent and exposure to HPCIAs were correlated with increased COVID severity (OR 1.19; 95% CI: 1.14–1.26; 1.41; 95% CI: 1.36–1.46; and 1.35; 95% CI: 1.30–1.40, respectively). Our findings confirm a significant correlation between previous antibiotic exposure and increased severity of COVID-19 disease. MDPI 2021-11-08 /pmc/articles/PMC8615228/ /pubmed/34827302 http://dx.doi.org/10.3390/antibiotics10111364 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Llor, Carl Ouchi, Dan Giner-Soriano, Maria García-Sangenís, Ana Bjerrum, Lars Morros, Rosa Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study |
title | Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study |
title_full | Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study |
title_fullStr | Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study |
title_full_unstemmed | Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study |
title_short | Correlation between Previous Antibiotic Exposure and COVID-19 Severity. A Population-Based Cohort Study |
title_sort | correlation between previous antibiotic exposure and covid-19 severity. a population-based cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615228/ https://www.ncbi.nlm.nih.gov/pubmed/34827302 http://dx.doi.org/10.3390/antibiotics10111364 |
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