Novel Structures of Type 1 Glyceraldehyde-3-phosphate Dehydrogenase from Escherichia coli Provide New Insights into the Mechanism of Generation of 1,3-Bisphosphoglyceric Acid

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a highly conserved enzyme involved in the ubiquitous process of glycolysis and presents a loop (residues 208–215 of Escherichia coli GAPDH) in two alternative conformations (I and II). It is uncertain what triggers this loop rearrangement, as well...

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Detalles Bibliográficos
Autores principales: Zhang, Li, Liu, Meiruo, Bao, Luyao, Boström, Kristina I., Yao, Yucheng, Li, Jixi, Gu, Shaohua, Ji, Chaoneng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615399/
https://www.ncbi.nlm.nih.gov/pubmed/34827563
http://dx.doi.org/10.3390/biom11111565

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