Cargando…

Cytotoxicity and Mitochondrial Effects of Phenolic and Quinone-Based Mitochondria-Targeted and Untargeted Antioxidants on Human Neuronal and Hepatic Cell Lines: A Comparative Analysis

Mitochondriotropic antioxidants (MC(3), MC(6.2), MC(4) and MC(7.2)) based on dietary antioxidants and analogs (caffeic, hydrocaffeic, trihydroxyphenylpropanoic and trihydroxycinnamic acids) were developed. In this study, we evaluate and compare the cytotoxicity profile of novel mitochondria-targeted...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fernandes, Carlos, Videira, Afonso J. C., Veloso, Caroline D., Benfeito, Sofia, Soares, Pedro, Martins, João D., Gonçalves, Beatriz, Duarte, José F. S., Santos, António M. S., Oliveira, Paulo J., Borges, Fernanda, Teixeira, José, Silva, Filomena S. G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615458/ https://www.ncbi.nlm.nih.gov/pubmed/34827603 http://dx.doi.org/10.3390/biom11111605

Ejemplares similares

Targeting Hydroxybenzoic Acids to Mitochondria as a Strategy to Delay Skin Ageing: An In Vitro Approach
por: Fernandes, Carlos, et al.
Publicado: (2022)

In Vitro Effects of Mitochondria-Targeted Antioxidants in a Small-Cell Carcinoma of the Ovary of Hypercalcemic Type and in Type 1 and Type 2 Endometrial Cancer
por: Castelôa, Mariana, et al.
Publicado: (2022)

A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients
por: Deus, Cláudia M., et al.
Publicado: (2021)

Cytotoxic Terpene Quinones from Marine Sponges
por: Gordaliza, Marina
Publicado: (2010)

Cytotoxic Quinones from the Roots of Aloe dawei
por: Abdissa, Negera, et al.
Publicado: (2014)

Corrigendum to ‘A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients’. [Redox Biology 45 (2021) 102037]
por: Deus, Cláudia M., et al.
Publicado: (2021)

Phenolics from Barleria cristata var. Alba as carcinogenesis blockers against menadione cytotoxicity through induction and protection of quinone reductase
por: El-Halawany, Ali M., et al.
Publicado: (2018)

IBS-Catalyzed Regioselective Oxidation of Phenols to 1,2-Quinones with Oxone(®)
por: Uyanik, Muhammet, et al.
Publicado: (2012)

Exploring the Multi-Target Performance of Mitochondriotropic Antioxidants against the Pivotal Alzheimer’s Disease Pathophysiological Hallmarks
por: Benfeito, Sofia, et al.
Publicado: (2020)

Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects
por: Bolton, Judy L., et al.
Publicado: (2016)

Correlation between Cytotoxic Activities and Reduction Potentials of Heterocyclic Quinones
por: Koyama, Junko, et al.
Publicado: (2010)

Quinones as Neuroprotective Agents
por: Cores, Ángel, et al.
Publicado: (2023)

Theoretical Confirmation of the Quinone Methide Hypothesis for the Condensation Reactions in Phenol-Formaldehyde Resin Synthesis
por: Li, Taohong, et al.
Publicado: (2017)

From Non-Alcoholic Fatty Liver to Hepatocellular Carcinoma: A Story of (Mal)Adapted Mitochondria
por: Amorim, Ricardo, et al.
Publicado: (2023)

The inhibitory effect of pyrroloquinoline quinone on the amyloid formation and cytotoxicity of truncated alpha-synuclein
por: Kim, Jihoon, et al.
Publicado: (2010)

New diterpenoid quinones derived from Salvia miltiorrhiza and their cytotoxic and neuroprotective activities
por: Yin, Zhao-Kun, et al.
Publicado: (2020)

Straightforward Synthesis of Bifunctional Phosphorus Phenols via Phosphination of In Situ Generated o-Quinone Methides
por: Chen, Zhangpei, et al.
Publicado: (2018)

Research Models to Study Ferroptosis’s Impact in Neurodegenerative Diseases
por: Costa, Inês, et al.
Publicado: (2023)

Biological effects of olive oil phenolic compounds on mitochondria
por: Blanco-Benítez, Mercedes, et al.
Publicado: (2022)

Chain-breaking antioxidant activity of reduced forms of mitochondria-targeted quinones, a novel type of geroprotectors
por: Roginsky, Vitaly A., et al.
Publicado: (2009)

Exploring the Contribution of (Poly)phenols to the Dietary Exposome Using High Resolution Mass Spectrometry Untargeted Metabolomics
por: Li, Yuan‐Yuan, et al.
Publicado: (2022)

Lipid Nanosystems and Serum Protein as Biomimetic Interfaces: Predicting the Biodistribution of a Caffeic Acid-Based Antioxidant
por: Fernandes, Eduarda, et al.
Publicado: (2021)

Honey Phenolic Compound Profiling and Authenticity Assessment Using HRMS Targeted and Untargeted Metabolomics
por: Koulis, Georgios A., et al.
Publicado: (2021)

A focused library synthesis and cytotoxicity of quinones derived from the natural product bolinaquinone
por: Ghods, Azadeh, et al.
Publicado: (2018)

Potent Cytotoxicity of Novel L-Shaped Ortho-Quinone Analogs through Inducing Apoptosis
por: Li, Sheng-You, et al.
Publicado: (2019)

Host-Guest Interaction between Herbicide Oxadiargyl and Hydroxypropyl-β-Cyclodextrin
por: Benfeito, Sofia, et al.
Publicado: (2013)

CORRELATION OF THE AQUARIUM GOLDFISH TOXICITIES OF SOME PHENOLS, QUINONES, AND OTHER BENZENE DERIVATIVES WITH THEIR INHIBITION OF AUTOOXIDATIVE REACTIONS
por: Sollmann, Torald
Publicado: (1949)

A Comprehensive Review of Natural Products against Liver Fibrosis: Flavonoids, Quinones, Lignans, Phenols, and Acids
por: Pan, Xiaoqi, et al.
Publicado: (2020)

Discovery of a new mitochondria permeability transition pore (mPTP) inhibitor based on gallic acid
por: Teixeira, José, et al.
Publicado: (2018)

Copper-assisted oxidation of catechols into quinone derivatives
por: Gómez-Herrero, Ana Cristina, et al.
Publicado: (2020)

Quinone binding site in a type VI sulfide:quinone oxidoreductase
por: Miklovics, Nikolett, et al.
Publicado: (2022)

Quinones as Promising Compounds against Respiratory Viruses: A Review
por: Chan-Zapata, Ivan, et al.
Publicado: (2023)

Attempted characterisation of phenanthrene-4,5-quinone and electrochemical synthesis of violanthrone-16,17-quinone. How does the stability of bay quinones correlate with structural and electronic parameters?
por: Wilkinson, Dylan, et al.
Publicado: (2020)

Untargeted Phenolic Profiling and Functional Insights of the Aerial Parts and Bulbs of Drimia maritima (L.) Stearn
por: Zhang, Leilei, et al.
Publicado: (2022)

Influence of Carbon Sources on the Phenolic Compound Production by Euglena gracilis Using an Untargeted Metabolomic Approach
por: Bernard, Eve, et al.
Publicado: (2022)

Unraveling the Mechanisms of Ch-SeNP Cytotoxicity against Cancer Cells: Insights from Targeted and Untargeted Metabolomics
por: Estevez, Hector, et al.
Publicado: (2023)

“Quinone Millipedes” Reconsidered: Evidence for a Mosaic-Like Taxonomic Distribution of Phenol-Based Secretions across the Julidae
por: Bodner, Michaela, et al.
Publicado: (2016)

Trapping para-Quinone Methide Intermediates with Ferrocene: Synthesis and Preliminary Biological Evaluation of New Phenol-Ferrocene Conjugates
por: González-Pelayo, Silvia, et al.
Publicado: (2018)

Selective Metal‐ion Complexation of a Biomimetic Calix[6]arene Funnel Cavity Functionalized with Phenol or Quinone
por: Aoun, Pamela, et al.
Publicado: (2022)

Cytotoxic Sesquiterpenoid Quinones and Quinols, and an 11-Membered Heterocycle, Kauamide, from the Hawaiian Marine Sponge Dactylospongia elegans
por: Neupane, Ram P., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_i0990a7rkeiutdk2gerb7of7s5