Cargando…
Circulating Omentin-1 as a Biomarker at the Intersection of Postmenopausal Breast Cancer Occurrence and Cardiometabolic Risk: An Observational Cross-Sectional Study
Aberrant circulating omentin-1, which is an anti-inflammatory and pro-apoptotic adipokine, has been reported in various solid tumors. Therefore, we investigated whether circulating omentin-1 could be associated with postmenopausal BC (PBC) and could be used as a potential diagnostic and clinical too...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615461/ https://www.ncbi.nlm.nih.gov/pubmed/34827610 http://dx.doi.org/10.3390/biom11111609 |
_version_ | 1784604110448754688 |
---|---|
author | Christodoulatos, Gerasimos Socrates Antonakos, Georgios Karampela, Irene Psallida, Sotiria Stratigou, Theodora Vallianou, Natalia Lekka, Antigoni Marinou, Ioanna Vogiatzakis, Evaggelos Kokoris, Styliani Papavassiliou, Athanasios G. Dalamaga, Maria |
author_facet | Christodoulatos, Gerasimos Socrates Antonakos, Georgios Karampela, Irene Psallida, Sotiria Stratigou, Theodora Vallianou, Natalia Lekka, Antigoni Marinou, Ioanna Vogiatzakis, Evaggelos Kokoris, Styliani Papavassiliou, Athanasios G. Dalamaga, Maria |
author_sort | Christodoulatos, Gerasimos Socrates |
collection | PubMed |
description | Aberrant circulating omentin-1, which is an anti-inflammatory and pro-apoptotic adipokine, has been reported in various solid tumors. Therefore, we investigated whether circulating omentin-1 could be associated with postmenopausal BC (PBC) and could be used as a potential diagnostic and clinical tool taking into consideration clinicopathologic features, tumor markers, as well as anthropometric, metabolic, and inflammatory parameters. Serum omentin-1, tumor markers (CA15-3 and CEA); metabolic (insulin, glucose, HOMA index, and serum lipids), anthropometric (BMI, waist circumference, and fat mass), and inflammatory (TNF-α, IL-6, hsCRP) parameters; classic adipokines (leptin and adiponectin); the Mediterranean diet (MedDiet) score; and cardiovascular (CVD) risk were determined in 103 postmenopausal women with pathologically confirmed incident invasive BC, 103 controls matched on age, 51 patients with benign breast lesions (BBL), and 50 obese postmenopausal women of similar age. The mean serum omentin-1 was significantly lower in cases than in controls and patients with BBL (p < 0.001). In the patients, omentin-1 was inversely associated with tumor, metabolic and inflammatory biomarkers, cancer stage, and the number of infiltrated lymph nodes (p < 0.05). In all study participants, omentin-1 was negatively correlated with CVD risk and positively correlated with MedDiet score. Lower circulating omentin-1 was independently associated with PBC occurrence above and beyond known risk factors. According to the ROC curve analysis, the overall diagnostic performance of omentin-1 (0.84, 95% CI 0.79–0.89) is similar to CA15-3. Circulating omentin-1 may be a biomarker at the intersection of PBC and cardiometabolic risk in postmenopausal women, and could be modulated by the adoption of a MedDiet. Further mechanistic and large multicentric prospective and longitudinal studies are required to elucidate the ontological role of omentin-1 in BC and CVD risks, as well as its diagnostic and prognostic ability and its therapeutic potential. |
format | Online Article Text |
id | pubmed-8615461 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86154612021-11-26 Circulating Omentin-1 as a Biomarker at the Intersection of Postmenopausal Breast Cancer Occurrence and Cardiometabolic Risk: An Observational Cross-Sectional Study Christodoulatos, Gerasimos Socrates Antonakos, Georgios Karampela, Irene Psallida, Sotiria Stratigou, Theodora Vallianou, Natalia Lekka, Antigoni Marinou, Ioanna Vogiatzakis, Evaggelos Kokoris, Styliani Papavassiliou, Athanasios G. Dalamaga, Maria Biomolecules Article Aberrant circulating omentin-1, which is an anti-inflammatory and pro-apoptotic adipokine, has been reported in various solid tumors. Therefore, we investigated whether circulating omentin-1 could be associated with postmenopausal BC (PBC) and could be used as a potential diagnostic and clinical tool taking into consideration clinicopathologic features, tumor markers, as well as anthropometric, metabolic, and inflammatory parameters. Serum omentin-1, tumor markers (CA15-3 and CEA); metabolic (insulin, glucose, HOMA index, and serum lipids), anthropometric (BMI, waist circumference, and fat mass), and inflammatory (TNF-α, IL-6, hsCRP) parameters; classic adipokines (leptin and adiponectin); the Mediterranean diet (MedDiet) score; and cardiovascular (CVD) risk were determined in 103 postmenopausal women with pathologically confirmed incident invasive BC, 103 controls matched on age, 51 patients with benign breast lesions (BBL), and 50 obese postmenopausal women of similar age. The mean serum omentin-1 was significantly lower in cases than in controls and patients with BBL (p < 0.001). In the patients, omentin-1 was inversely associated with tumor, metabolic and inflammatory biomarkers, cancer stage, and the number of infiltrated lymph nodes (p < 0.05). In all study participants, omentin-1 was negatively correlated with CVD risk and positively correlated with MedDiet score. Lower circulating omentin-1 was independently associated with PBC occurrence above and beyond known risk factors. According to the ROC curve analysis, the overall diagnostic performance of omentin-1 (0.84, 95% CI 0.79–0.89) is similar to CA15-3. Circulating omentin-1 may be a biomarker at the intersection of PBC and cardiometabolic risk in postmenopausal women, and could be modulated by the adoption of a MedDiet. Further mechanistic and large multicentric prospective and longitudinal studies are required to elucidate the ontological role of omentin-1 in BC and CVD risks, as well as its diagnostic and prognostic ability and its therapeutic potential. MDPI 2021-10-30 /pmc/articles/PMC8615461/ /pubmed/34827610 http://dx.doi.org/10.3390/biom11111609 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Christodoulatos, Gerasimos Socrates Antonakos, Georgios Karampela, Irene Psallida, Sotiria Stratigou, Theodora Vallianou, Natalia Lekka, Antigoni Marinou, Ioanna Vogiatzakis, Evaggelos Kokoris, Styliani Papavassiliou, Athanasios G. Dalamaga, Maria Circulating Omentin-1 as a Biomarker at the Intersection of Postmenopausal Breast Cancer Occurrence and Cardiometabolic Risk: An Observational Cross-Sectional Study |
title | Circulating Omentin-1 as a Biomarker at the Intersection of Postmenopausal Breast Cancer Occurrence and Cardiometabolic Risk: An Observational Cross-Sectional Study |
title_full | Circulating Omentin-1 as a Biomarker at the Intersection of Postmenopausal Breast Cancer Occurrence and Cardiometabolic Risk: An Observational Cross-Sectional Study |
title_fullStr | Circulating Omentin-1 as a Biomarker at the Intersection of Postmenopausal Breast Cancer Occurrence and Cardiometabolic Risk: An Observational Cross-Sectional Study |
title_full_unstemmed | Circulating Omentin-1 as a Biomarker at the Intersection of Postmenopausal Breast Cancer Occurrence and Cardiometabolic Risk: An Observational Cross-Sectional Study |
title_short | Circulating Omentin-1 as a Biomarker at the Intersection of Postmenopausal Breast Cancer Occurrence and Cardiometabolic Risk: An Observational Cross-Sectional Study |
title_sort | circulating omentin-1 as a biomarker at the intersection of postmenopausal breast cancer occurrence and cardiometabolic risk: an observational cross-sectional study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615461/ https://www.ncbi.nlm.nih.gov/pubmed/34827610 http://dx.doi.org/10.3390/biom11111609 |
work_keys_str_mv | AT christodoulatosgerasimossocrates circulatingomentin1asabiomarkerattheintersectionofpostmenopausalbreastcanceroccurrenceandcardiometabolicriskanobservationalcrosssectionalstudy AT antonakosgeorgios circulatingomentin1asabiomarkerattheintersectionofpostmenopausalbreastcanceroccurrenceandcardiometabolicriskanobservationalcrosssectionalstudy AT karampelairene circulatingomentin1asabiomarkerattheintersectionofpostmenopausalbreastcanceroccurrenceandcardiometabolicriskanobservationalcrosssectionalstudy AT psallidasotiria circulatingomentin1asabiomarkerattheintersectionofpostmenopausalbreastcanceroccurrenceandcardiometabolicriskanobservationalcrosssectionalstudy AT stratigoutheodora circulatingomentin1asabiomarkerattheintersectionofpostmenopausalbreastcanceroccurrenceandcardiometabolicriskanobservationalcrosssectionalstudy AT vallianounatalia circulatingomentin1asabiomarkerattheintersectionofpostmenopausalbreastcanceroccurrenceandcardiometabolicriskanobservationalcrosssectionalstudy AT lekkaantigoni circulatingomentin1asabiomarkerattheintersectionofpostmenopausalbreastcanceroccurrenceandcardiometabolicriskanobservationalcrosssectionalstudy AT marinouioanna circulatingomentin1asabiomarkerattheintersectionofpostmenopausalbreastcanceroccurrenceandcardiometabolicriskanobservationalcrosssectionalstudy AT vogiatzakisevaggelos circulatingomentin1asabiomarkerattheintersectionofpostmenopausalbreastcanceroccurrenceandcardiometabolicriskanobservationalcrosssectionalstudy AT kokorisstyliani circulatingomentin1asabiomarkerattheintersectionofpostmenopausalbreastcanceroccurrenceandcardiometabolicriskanobservationalcrosssectionalstudy AT papavassiliouathanasiosg circulatingomentin1asabiomarkerattheintersectionofpostmenopausalbreastcanceroccurrenceandcardiometabolicriskanobservationalcrosssectionalstudy AT dalamagamaria circulatingomentin1asabiomarkerattheintersectionofpostmenopausalbreastcanceroccurrenceandcardiometabolicriskanobservationalcrosssectionalstudy |