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Characteristics of Dental Resin-Based Composites in Leukemia Saliva: An In Vitro Analysis

Background: The aim was to analyze, in vitro, four resin based composite systems (RBCs) immersed in saliva of leukemia patients before starting chemotherapy regiments. Material and methods: Saliva was collected from 20 patients (4 healthy patients, 16 leukemia patients). Resin disks were made for ea...

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Autores principales: Mester, Alexandru, Moldovan, Marioara, Cuc, Stanca, Tomuleasa, Ciprian, Pasca, Sergiu, Filip, Miuta, Piciu, Andra, Onisor, Florin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615474/
https://www.ncbi.nlm.nih.gov/pubmed/34829847
http://dx.doi.org/10.3390/biomedicines9111618
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author Mester, Alexandru
Moldovan, Marioara
Cuc, Stanca
Tomuleasa, Ciprian
Pasca, Sergiu
Filip, Miuta
Piciu, Andra
Onisor, Florin
author_facet Mester, Alexandru
Moldovan, Marioara
Cuc, Stanca
Tomuleasa, Ciprian
Pasca, Sergiu
Filip, Miuta
Piciu, Andra
Onisor, Florin
author_sort Mester, Alexandru
collection PubMed
description Background: The aim was to analyze, in vitro, four resin based composite systems (RBCs) immersed in saliva of leukemia patients before starting chemotherapy regiments. Material and methods: Saliva was collected from 20 patients (4 healthy patients, 16 leukemia patients). Resin disks were made for each RBC and were immersed in the acute leukemia (acute lymphocytic (ALL), acute myeloid (AML)), chronic leukemia (chronic lymphocytic (CLL), chronic myeloid (CML)), Artificial saliva and Control environment, and maintained for seven days. At the end of the experiment, the characteristics and the effective response of saliva from the studied salivas’ on RBCs was assessed using water sorption, water solubility, residual monomer and scanning electron microscopy (SEM). Data analysis was performed and a p-value under 0.05 was considered statistically significant. Results: The behaviour of RBCs in different immersion environments varies according to the characteristics of the RBCs. RBCs with a higher filler ratio have a lower water sorption. The solubility is also deteriorated by the types of organic matrix and filler; the results of solubility being inversely proportional on the scale of negative values compared to sorption values. Chromatograms of residual monomers showed the highest amount of unreacted monomers in ALL and AML, and the Control and artificial saliva environments had the smallest residual monomer peaks. Because of the low number of differences between the experimental conditions, we further considered that there were no important statistical differences between experimental conditions and analysed them as a single group. Conclusion: The influence of saliva on RBCs depends on the type of leukemia; acute leukemia influenced the most RBCs by changing their properties compared to chronic leukemia.
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spelling pubmed-86154742021-11-26 Characteristics of Dental Resin-Based Composites in Leukemia Saliva: An In Vitro Analysis Mester, Alexandru Moldovan, Marioara Cuc, Stanca Tomuleasa, Ciprian Pasca, Sergiu Filip, Miuta Piciu, Andra Onisor, Florin Biomedicines Article Background: The aim was to analyze, in vitro, four resin based composite systems (RBCs) immersed in saliva of leukemia patients before starting chemotherapy regiments. Material and methods: Saliva was collected from 20 patients (4 healthy patients, 16 leukemia patients). Resin disks were made for each RBC and were immersed in the acute leukemia (acute lymphocytic (ALL), acute myeloid (AML)), chronic leukemia (chronic lymphocytic (CLL), chronic myeloid (CML)), Artificial saliva and Control environment, and maintained for seven days. At the end of the experiment, the characteristics and the effective response of saliva from the studied salivas’ on RBCs was assessed using water sorption, water solubility, residual monomer and scanning electron microscopy (SEM). Data analysis was performed and a p-value under 0.05 was considered statistically significant. Results: The behaviour of RBCs in different immersion environments varies according to the characteristics of the RBCs. RBCs with a higher filler ratio have a lower water sorption. The solubility is also deteriorated by the types of organic matrix and filler; the results of solubility being inversely proportional on the scale of negative values compared to sorption values. Chromatograms of residual monomers showed the highest amount of unreacted monomers in ALL and AML, and the Control and artificial saliva environments had the smallest residual monomer peaks. Because of the low number of differences between the experimental conditions, we further considered that there were no important statistical differences between experimental conditions and analysed them as a single group. Conclusion: The influence of saliva on RBCs depends on the type of leukemia; acute leukemia influenced the most RBCs by changing their properties compared to chronic leukemia. MDPI 2021-11-04 /pmc/articles/PMC8615474/ /pubmed/34829847 http://dx.doi.org/10.3390/biomedicines9111618 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mester, Alexandru
Moldovan, Marioara
Cuc, Stanca
Tomuleasa, Ciprian
Pasca, Sergiu
Filip, Miuta
Piciu, Andra
Onisor, Florin
Characteristics of Dental Resin-Based Composites in Leukemia Saliva: An In Vitro Analysis
title Characteristics of Dental Resin-Based Composites in Leukemia Saliva: An In Vitro Analysis
title_full Characteristics of Dental Resin-Based Composites in Leukemia Saliva: An In Vitro Analysis
title_fullStr Characteristics of Dental Resin-Based Composites in Leukemia Saliva: An In Vitro Analysis
title_full_unstemmed Characteristics of Dental Resin-Based Composites in Leukemia Saliva: An In Vitro Analysis
title_short Characteristics of Dental Resin-Based Composites in Leukemia Saliva: An In Vitro Analysis
title_sort characteristics of dental resin-based composites in leukemia saliva: an in vitro analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615474/
https://www.ncbi.nlm.nih.gov/pubmed/34829847
http://dx.doi.org/10.3390/biomedicines9111618
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