Cargando…

The Physiological and Pathological Role of Tissue Nonspecific Alkaline Phosphatase beyond Mineralization

Tissue-nonspecific alkaline phosphatase (TNAP) is a key enzyme responsible for skeletal tissue mineralization. It is involved in the dephosphorylation of various physiological substrates, and has vital physiological functions, including extra-skeletal functions, such as neuronal development, detoxif...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sekaran, Saravanan, Vimalraj, Selvaraj, Thangavelu, Lakshmi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615537/ https://www.ncbi.nlm.nih.gov/pubmed/34827562 http://dx.doi.org/10.3390/biom11111564

Ejemplares similares

RUNX Family as a Promising Biomarker and a Therapeutic Target in Bone Cancers: A Review on Its Molecular Mechanism(s) behind Tumorigenesis
por: Vimalraj, Selvaraj, et al.
Publicado: (2023)

Tissue-Nonspecific Alkaline Phosphatase—A Gatekeeper of Physiological Conditions in Health and a Modulator of Biological Environments in Disease
por: Liedtke, Daniel, et al.
Publicado: (2020)

Functional Significance of Calcium Binding to Tissue-Nonspecific Alkaline Phosphatase
por: Hoylaerts, Marc F., et al.
Publicado: (2015)

The functional co-operativity of tissue-nonspecific alkaline phosphatase (TNAP) and PHOSPHO1 during initiation of skeletal mineralization.
por: Huesa, Carmen, et al.
Publicado: (2015)

Tissue-nonspecific alkaline phosphatase promotes axonal growth of hippocampal neurons
por: Díez-Zaera, M., et al.
Publicado: (2011)

Commentary: “Silver Nanoparticles Coated Poly(L-Lactide) Electrospun Membrane for Implant Associated Infections Prevention”
por: Vimalraj, Selvaraj, et al.
Publicado: (2021)

A novel role for tissue-nonspecific alkaline phosphatase at the blood-brain barrier during sepsis
por: Nwafor, Divine C., et al.
Publicado: (2020)

Tissue-Nonspecific Alkaline Phosphatase, a Possible Mediator of Cell Maturation: Towards a New Paradigm
por: Sato, Masahiro, et al.
Publicado: (2021)

Tissue-nonspecific Alkaline Phosphatase Regulates Purinergic Transmission in the Central Nervous System During Development and Disease
por: Sebastián-Serrano, Álvaro, et al.
Publicado: (2014)

Tissue Nonspecific Alkaline Phosphatase (TNAP) Regulates Cranial Base Growth and Synchondrosis Maturation
por: Nam, Hwa K., et al.
Publicado: (2017)

Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis
por: Brichacek, Allison L., et al.
Publicado: (2019)

Tissue-Nonspecific Alkaline Phosphatase in Central Nervous System Health and Disease: A Focus on Brain Microvascular Endothelial Cells
por: Nwafor, Divine C., et al.
Publicado: (2021)

Transgenic Overexpression of Tissue‐Nonspecific Alkaline Phosphatase (TNAP) in Vascular Endothelium Results in Generalized Arterial Calcification
por: Savinov, Alexei Y., et al.
Publicado: (2015)

Surgical intervention paradoxically enhances micrometastasis – targeting perioperative variables
por: Selvaraj, Vimalraj, et al.
Publicado: (2023)

Surgical intervention as a driver of new angiogenesis in tumors—time to consider minimally invasive surgeries?
por: Selvaraj, Vimalraj, et al.
Publicado: (2023)

Advancing postoperative pain management in humans with miRNA-based therapeutic strategies: lacunae that need to be addressed
por: Selvaraj, Vimalraj, et al.
Publicado: (2023)

Tissue Nonspecific Alkaline Phosphatase Function in Bone and Muscle Progenitor Cells: Control of Mitochondrial Respiration and ATP Production
por: Zhang, Zhi, et al.
Publicado: (2021)

Assay Format as a Critical Success Factor for Identification of Novel Inhibitor Chemotypes of Tissue-Nonspecific Alkaline Phosphatase from High-Throughput Screening
por: Chung, Thomas D.Y., et al.
Publicado: (2010)

Flavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling
por: Ramesh, Priyanka, et al.
Publicado: (2021)

Can surgery induce cancer recurrence or metastasis? Revisiting the relationship between anesthetic selection and outcomes in cancer surgery
por: Sekaran, Saravanan, et al.
Publicado: (2023)

Tissue-Nonspecific Alkaline Phosphatase (TNAP) as the Enzyme Involved in the Degradation of Nucleotide Analogues in the Ligand Docking and Molecular Dynamics Approaches
por: Madaj, Rafal, et al.
Publicado: (2021)

Phase I studies of the safety, tolerability, pharmacokinetics, and pharmacodynamics of DS‐1211, a tissue‐nonspecific alkaline phosphatase inhibitor
por: Maruyama, Sonomi, et al.
Publicado: (2022)

Anticalcification effects of DS-1211 in pseudoxanthoma elasticum mouse models and the role of tissue-nonspecific alkaline phosphatase in ABCC6-deficient ectopic calcification
por: Soma, Kaori, et al.
Publicado: (2022)

Alkaline Phosphatase and Hypophosphatasia
por: Millán, José Luis, et al.
Publicado: (2015)

Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia
por: Romanelli, Filippo, et al.
Publicado: (2017)

In Vitro and In Vivo Pharmacological Profiles of DS‐1211, a Novel Potent, Selective, and Orally Bioavailable Tissue‐Nonspecific Alkaline Phosphatase Inhibitor
por: Soma, Kaori, et al.
Publicado: (2022)

Role of Intestinal Alkaline Phosphatase in Innate Immunity
por: Singh, Sudha B., et al.
Publicado: (2021)

The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase
por: Yu, Yating, et al.
Publicado: (2023)

THE ROLE OF ALKALINE PHOSPHATASE IN OSTEOGENESIS
por: Siffert, Robert S.
Publicado: (1951)

Bone Alkaline Phosphatase and Tartrate-Resistant Acid Phosphatase: Potential Co-regulators of Bone Mineralization
por: Halling Linder, Cecilia, et al.
Publicado: (2017)

Alkaline phosphatase is a predictor of Bone Mineral Density in postmenopausal females
por: Tariq, Sundus, et al.
Publicado: (2019)

Imaging of Alkaline Phosphatase Activity in Bone Tissue
por: Gade, Terence P., et al.
Publicado: (2011)

Viral delivery of tissue nonspecific alkaline phosphatase diminishes craniosynostosis in one of two FGFR2(C342Y/+) mouse models of Crouzon syndrome
por: Nam, Hwa Kyung, et al.
Publicado: (2020)

Phospholipases of Mineralization Competent Cells and Matrix Vesicles: Roles in Physiological and Pathological Mineralizations
por: Mebarek, Saida, et al.
Publicado: (2013)

Alkaline Phosphatase in Stem Cells
por: Štefková, Kateřina, et al.
Publicado: (2015)

Alkaline Phosphatase: An Old Friend as Treatment Target for Cardiovascular and Mineral Bone Disorders in Chronic Kidney Disease
por: Haarhaus, Mathias, et al.
Publicado: (2022)

The Role of Intestinal Alkaline Phosphatase in Inflammatory Disorders of Gastrointestinal Tract
por: Bilski, Jan, et al.
Publicado: (2017)

Reappraisal of the Role of Alkaline Phosphatase in Hepatocellular Carcinoma
por: Huang, Chun-Wei, et al.
Publicado: (2022)

Associations between bone-alkaline phosphatase and bone mineral density in adults with and without diabetes
por: Chen, Hailing, et al.
Publicado: (2018)

Association of serum chemerin with calcium, alkaline phosphatase and bone mineral density in postmenopausal females
por: Tariq, Saba, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_dk3difi0bojd3i1q2k6q5sipsb