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Connection Lost, MAM: Errors in ER–Mitochondria Connections in Neurodegenerative Diseases

Mitochondria associated membranes (MAMs), as the name suggests, are the membranes that physically and biochemically connect mitochondria with endoplasmic reticulum. MAMs not only structurally but also functionally connect these two important organelles within the cell which were previously thought t...

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Detalles Bibliográficos
Autores principales: Johri, Ashu, Chandra, Abhishek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615542/
https://www.ncbi.nlm.nih.gov/pubmed/34827436
http://dx.doi.org/10.3390/brainsci11111437
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author Johri, Ashu
Chandra, Abhishek
author_facet Johri, Ashu
Chandra, Abhishek
author_sort Johri, Ashu
collection PubMed
description Mitochondria associated membranes (MAMs), as the name suggests, are the membranes that physically and biochemically connect mitochondria with endoplasmic reticulum. MAMs not only structurally but also functionally connect these two important organelles within the cell which were previously thought to exist independently. There are multiple points of communication between ER–mitochondria and MAMs play an important role in both ER and mitochondria functions such as Ca(2+) homeostasis, proteostasis, mitochondrial bioenergetics, movement, and mitophagy. The number of disease-related proteins and genes being associated with MAMs has been continually on the rise since its discovery. There is an overwhelming overlap between the biochemical functions of MAMs and processes affected in neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD). Thus, MAMs have received well-deserving and much delayed attention as modulators for ER–mitochondria communication and function. This review briefly discusses the recent progress made in this now fast developing field full of promise for very exciting future therapeutic discoveries.
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spelling pubmed-86155422021-11-26 Connection Lost, MAM: Errors in ER–Mitochondria Connections in Neurodegenerative Diseases Johri, Ashu Chandra, Abhishek Brain Sci Review Mitochondria associated membranes (MAMs), as the name suggests, are the membranes that physically and biochemically connect mitochondria with endoplasmic reticulum. MAMs not only structurally but also functionally connect these two important organelles within the cell which were previously thought to exist independently. There are multiple points of communication between ER–mitochondria and MAMs play an important role in both ER and mitochondria functions such as Ca(2+) homeostasis, proteostasis, mitochondrial bioenergetics, movement, and mitophagy. The number of disease-related proteins and genes being associated with MAMs has been continually on the rise since its discovery. There is an overwhelming overlap between the biochemical functions of MAMs and processes affected in neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD). Thus, MAMs have received well-deserving and much delayed attention as modulators for ER–mitochondria communication and function. This review briefly discusses the recent progress made in this now fast developing field full of promise for very exciting future therapeutic discoveries. MDPI 2021-10-28 /pmc/articles/PMC8615542/ /pubmed/34827436 http://dx.doi.org/10.3390/brainsci11111437 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Johri, Ashu
Chandra, Abhishek
Connection Lost, MAM: Errors in ER–Mitochondria Connections in Neurodegenerative Diseases
title Connection Lost, MAM: Errors in ER–Mitochondria Connections in Neurodegenerative Diseases
title_full Connection Lost, MAM: Errors in ER–Mitochondria Connections in Neurodegenerative Diseases
title_fullStr Connection Lost, MAM: Errors in ER–Mitochondria Connections in Neurodegenerative Diseases
title_full_unstemmed Connection Lost, MAM: Errors in ER–Mitochondria Connections in Neurodegenerative Diseases
title_short Connection Lost, MAM: Errors in ER–Mitochondria Connections in Neurodegenerative Diseases
title_sort connection lost, mam: errors in er–mitochondria connections in neurodegenerative diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615542/
https://www.ncbi.nlm.nih.gov/pubmed/34827436
http://dx.doi.org/10.3390/brainsci11111437
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