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Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression

Signaling from an actively remodeling extracellular matrix (ECM) has emerged as a critical factor in regulating both the repair of tissue injuries and the progression of diseases such as metastatic cancer. Hyaluronan (HA) is a major component of the ECM that normally functions in tissue injury to se...

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Autores principales: Tolg, Cornelia, Messam, Britney Jodi-Ann, McCarthy, James Benjamin, Nelson, Andrew Cook, Turley, Eva Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615562/
https://www.ncbi.nlm.nih.gov/pubmed/34827550
http://dx.doi.org/10.3390/biom11111551
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author Tolg, Cornelia
Messam, Britney Jodi-Ann
McCarthy, James Benjamin
Nelson, Andrew Cook
Turley, Eva Ann
author_facet Tolg, Cornelia
Messam, Britney Jodi-Ann
McCarthy, James Benjamin
Nelson, Andrew Cook
Turley, Eva Ann
author_sort Tolg, Cornelia
collection PubMed
description Signaling from an actively remodeling extracellular matrix (ECM) has emerged as a critical factor in regulating both the repair of tissue injuries and the progression of diseases such as metastatic cancer. Hyaluronan (HA) is a major component of the ECM that normally functions in tissue injury to sequentially promote then suppress inflammation and fibrosis, a duality in which is featured, and regulated in, wound repair. These essential response-to-injury functions of HA in the microenvironment are hijacked by tumor cells for invasion and avoidance of immune detection. In this review, we first discuss the numerous size-dependent functions of HA and emphasize the multifunctional nature of two of its receptors (CD44 and RHAMM) in regulating the signaling duality of HA in excisional wound healing. This is followed by a discussion of how HA metabolism is de-regulated in malignant progression and how targeting HA might be used to better manage breast cancer progression.
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spelling pubmed-86155622021-11-26 Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression Tolg, Cornelia Messam, Britney Jodi-Ann McCarthy, James Benjamin Nelson, Andrew Cook Turley, Eva Ann Biomolecules Review Signaling from an actively remodeling extracellular matrix (ECM) has emerged as a critical factor in regulating both the repair of tissue injuries and the progression of diseases such as metastatic cancer. Hyaluronan (HA) is a major component of the ECM that normally functions in tissue injury to sequentially promote then suppress inflammation and fibrosis, a duality in which is featured, and regulated in, wound repair. These essential response-to-injury functions of HA in the microenvironment are hijacked by tumor cells for invasion and avoidance of immune detection. In this review, we first discuss the numerous size-dependent functions of HA and emphasize the multifunctional nature of two of its receptors (CD44 and RHAMM) in regulating the signaling duality of HA in excisional wound healing. This is followed by a discussion of how HA metabolism is de-regulated in malignant progression and how targeting HA might be used to better manage breast cancer progression. MDPI 2021-10-20 /pmc/articles/PMC8615562/ /pubmed/34827550 http://dx.doi.org/10.3390/biom11111551 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tolg, Cornelia
Messam, Britney Jodi-Ann
McCarthy, James Benjamin
Nelson, Andrew Cook
Turley, Eva Ann
Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression
title Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression
title_full Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression
title_fullStr Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression
title_full_unstemmed Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression
title_short Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression
title_sort hyaluronan functions in wound repair that are captured to fuel breast cancer progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615562/
https://www.ncbi.nlm.nih.gov/pubmed/34827550
http://dx.doi.org/10.3390/biom11111551
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