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A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis

Electrical impedance biosensors combined with microfluidic devices can be used to analyze fundamental biological processes for high-throughput analysis at the single-cell scale. These specialized analytical tools can determine the effectiveness and toxicity of drugs with high sensitivity and demonst...

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Autores principales: Kim, Soojung, Song, Hyerin, Ahn, Heesang, Kim, Taeyeon, Jung, Jihyun, Cho, Soo Kyung, Shin, Dong-Myeong, Choi, Jong-ryul, Hwang, Yoon-Hwae, Kim, Kyujung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615569/
https://www.ncbi.nlm.nih.gov/pubmed/34821628
http://dx.doi.org/10.3390/bios11110412
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author Kim, Soojung
Song, Hyerin
Ahn, Heesang
Kim, Taeyeon
Jung, Jihyun
Cho, Soo Kyung
Shin, Dong-Myeong
Choi, Jong-ryul
Hwang, Yoon-Hwae
Kim, Kyujung
author_facet Kim, Soojung
Song, Hyerin
Ahn, Heesang
Kim, Taeyeon
Jung, Jihyun
Cho, Soo Kyung
Shin, Dong-Myeong
Choi, Jong-ryul
Hwang, Yoon-Hwae
Kim, Kyujung
author_sort Kim, Soojung
collection PubMed
description Electrical impedance biosensors combined with microfluidic devices can be used to analyze fundamental biological processes for high-throughput analysis at the single-cell scale. These specialized analytical tools can determine the effectiveness and toxicity of drugs with high sensitivity and demonstrate biological functions on a single-cell scale. Because the various parameters of the cells can be measured depending on methods of single-cell trapping, technological development ultimately determine the efficiency and performance of the sensors. Identifying the latest trends in single-cell trapping technologies afford opportunities such as new structural design and combination with other technologies. This will lead to more advanced applications towards improving measurement sensitivity to the desired target. In this review, we examined the basic principles of impedance sensors and their applications in various biological fields. In the next step, we introduced the latest trend of microfluidic chip technology for trapping single cells and summarized the important findings on the characteristics of single cells in impedance biosensor systems that successfully trapped single cells. This is expected to be used as a leading technology in cell biology, pathology, and pharmacological fields, promoting the further understanding of complex functions and mechanisms within individual cells with numerous data sampling and accurate analysis capabilities.
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spelling pubmed-86155692021-11-26 A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis Kim, Soojung Song, Hyerin Ahn, Heesang Kim, Taeyeon Jung, Jihyun Cho, Soo Kyung Shin, Dong-Myeong Choi, Jong-ryul Hwang, Yoon-Hwae Kim, Kyujung Biosensors (Basel) Review Electrical impedance biosensors combined with microfluidic devices can be used to analyze fundamental biological processes for high-throughput analysis at the single-cell scale. These specialized analytical tools can determine the effectiveness and toxicity of drugs with high sensitivity and demonstrate biological functions on a single-cell scale. Because the various parameters of the cells can be measured depending on methods of single-cell trapping, technological development ultimately determine the efficiency and performance of the sensors. Identifying the latest trends in single-cell trapping technologies afford opportunities such as new structural design and combination with other technologies. This will lead to more advanced applications towards improving measurement sensitivity to the desired target. In this review, we examined the basic principles of impedance sensors and their applications in various biological fields. In the next step, we introduced the latest trend of microfluidic chip technology for trapping single cells and summarized the important findings on the characteristics of single cells in impedance biosensor systems that successfully trapped single cells. This is expected to be used as a leading technology in cell biology, pathology, and pharmacological fields, promoting the further understanding of complex functions and mechanisms within individual cells with numerous data sampling and accurate analysis capabilities. MDPI 2021-10-22 /pmc/articles/PMC8615569/ /pubmed/34821628 http://dx.doi.org/10.3390/bios11110412 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kim, Soojung
Song, Hyerin
Ahn, Heesang
Kim, Taeyeon
Jung, Jihyun
Cho, Soo Kyung
Shin, Dong-Myeong
Choi, Jong-ryul
Hwang, Yoon-Hwae
Kim, Kyujung
A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis
title A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis
title_full A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis
title_fullStr A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis
title_full_unstemmed A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis
title_short A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis
title_sort review of advanced impedance biosensors with microfluidic chips for single-cell analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615569/
https://www.ncbi.nlm.nih.gov/pubmed/34821628
http://dx.doi.org/10.3390/bios11110412
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