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LncRNAs: Novel Biomarkers for Pancreatic Cancer

Pancreatic cancer is one of the most deadly neoplasms and the seventh major cause of cancer-related deaths among both males and females. This cancer has a poor prognosis due to the lack of appropriate methods for early detection of cancer. Long non-coding RNAs (lncRNAs) have been recently found to i...

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Autores principales: Ghafouri-Fard, Soudeh, Fathi, Mohadeseh, Zhai, Tianyue, Taheri, Mohammad, Dong, Peixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615627/
https://www.ncbi.nlm.nih.gov/pubmed/34827663
http://dx.doi.org/10.3390/biom11111665
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author Ghafouri-Fard, Soudeh
Fathi, Mohadeseh
Zhai, Tianyue
Taheri, Mohammad
Dong, Peixin
author_facet Ghafouri-Fard, Soudeh
Fathi, Mohadeseh
Zhai, Tianyue
Taheri, Mohammad
Dong, Peixin
author_sort Ghafouri-Fard, Soudeh
collection PubMed
description Pancreatic cancer is one of the most deadly neoplasms and the seventh major cause of cancer-related deaths among both males and females. This cancer has a poor prognosis due to the lack of appropriate methods for early detection of cancer. Long non-coding RNAs (lncRNAs) have been recently found to influence the progression and initiation of pancreatic cancer. MACC1-AS1, LINC00976, LINC00462, LINC01559, HOXA-AS2, LINC00152, TP73-AS1, XIST, SNHG12, LUCAT1, and UCA1 are among the oncogenic lncRNAs in pancreatic cancer. On the other hand, LINC01111, LINC01963, DGCR5, MEG3, GAS5, and LINC00261 are among tumor suppressor lncRNAs in this tissue. In the current review, we summarize the roles of these two classes of lncRNAs in pancreatic cancer and discuss their potential as attractive diagnostic and prognostic biomarkers for pancreatic cancer. We also identified that the low expression of MEG3, LINC01963, and LINC00261 and the high expression of MACC1-AS1, LINC00462, LINC01559, and UCA1 were significantly correlated with worse survival in pancreatic cancer patients. Further research on these lncRNAs will provide new clues that could potentially improve the early diagnosis, prognostic prediction, and personalized treatments of patients with pancreatic cancer.
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spelling pubmed-86156272021-11-26 LncRNAs: Novel Biomarkers for Pancreatic Cancer Ghafouri-Fard, Soudeh Fathi, Mohadeseh Zhai, Tianyue Taheri, Mohammad Dong, Peixin Biomolecules Review Pancreatic cancer is one of the most deadly neoplasms and the seventh major cause of cancer-related deaths among both males and females. This cancer has a poor prognosis due to the lack of appropriate methods for early detection of cancer. Long non-coding RNAs (lncRNAs) have been recently found to influence the progression and initiation of pancreatic cancer. MACC1-AS1, LINC00976, LINC00462, LINC01559, HOXA-AS2, LINC00152, TP73-AS1, XIST, SNHG12, LUCAT1, and UCA1 are among the oncogenic lncRNAs in pancreatic cancer. On the other hand, LINC01111, LINC01963, DGCR5, MEG3, GAS5, and LINC00261 are among tumor suppressor lncRNAs in this tissue. In the current review, we summarize the roles of these two classes of lncRNAs in pancreatic cancer and discuss their potential as attractive diagnostic and prognostic biomarkers for pancreatic cancer. We also identified that the low expression of MEG3, LINC01963, and LINC00261 and the high expression of MACC1-AS1, LINC00462, LINC01559, and UCA1 were significantly correlated with worse survival in pancreatic cancer patients. Further research on these lncRNAs will provide new clues that could potentially improve the early diagnosis, prognostic prediction, and personalized treatments of patients with pancreatic cancer. MDPI 2021-11-10 /pmc/articles/PMC8615627/ /pubmed/34827663 http://dx.doi.org/10.3390/biom11111665 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ghafouri-Fard, Soudeh
Fathi, Mohadeseh
Zhai, Tianyue
Taheri, Mohammad
Dong, Peixin
LncRNAs: Novel Biomarkers for Pancreatic Cancer
title LncRNAs: Novel Biomarkers for Pancreatic Cancer
title_full LncRNAs: Novel Biomarkers for Pancreatic Cancer
title_fullStr LncRNAs: Novel Biomarkers for Pancreatic Cancer
title_full_unstemmed LncRNAs: Novel Biomarkers for Pancreatic Cancer
title_short LncRNAs: Novel Biomarkers for Pancreatic Cancer
title_sort lncrnas: novel biomarkers for pancreatic cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615627/
https://www.ncbi.nlm.nih.gov/pubmed/34827663
http://dx.doi.org/10.3390/biom11111665
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