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Comparison of Characteristics and Survival Rates of Resectable Pancreatic Ductal Adenocarcinoma according to Tumor Location

The impact of tumor location on patient survival in pancreatic ductal adenocarcinoma (PDAC) remains controversial. This study investigated the association between primary tumor location and survival rates for resectable PDAC. Additionally, we assessed if this association remains consistent across ca...

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Autores principales: Sung, Min Kyu, Park, Yejong, Kwak, Bong Jun, Jun, Eunsung, Lee, Woohyung, Song, Ki Byung, Lee, Jae Hoon, Hwang, Dae Wook, Kim, Song Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615679/
https://www.ncbi.nlm.nih.gov/pubmed/34829935
http://dx.doi.org/10.3390/biomedicines9111706
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author Sung, Min Kyu
Park, Yejong
Kwak, Bong Jun
Jun, Eunsung
Lee, Woohyung
Song, Ki Byung
Lee, Jae Hoon
Hwang, Dae Wook
Kim, Song Cheol
author_facet Sung, Min Kyu
Park, Yejong
Kwak, Bong Jun
Jun, Eunsung
Lee, Woohyung
Song, Ki Byung
Lee, Jae Hoon
Hwang, Dae Wook
Kim, Song Cheol
author_sort Sung, Min Kyu
collection PubMed
description The impact of tumor location on patient survival in pancreatic ductal adenocarcinoma (PDAC) remains controversial. This study investigated the association between primary tumor location and survival rates for resectable PDAC. Additionally, we assessed if this association remains consistent across categories of the Tumor-Node-Metastasis staging system. We analyzed 2471 patients who underwent surgical resection between 2000 and 2018 at a single center. Subgroup analysis was performed according to the Tumor-Node-Metastasis staging system. Among the group, 67.9% (1677 patients) had pancreatic head cancer (PHC) and 32.1% (794 patients) had pancreatic body/tail cancer (PBTC). Patients with PHC had worse overall survival and worse disease-free survival than those with PBTC. Patients with PHC had worse survival in stage IB and stage IIB than those with PBTC. No significant difference was observed for stages IA, IIA, and III. Multivariate analysis showed that elevated CA 19-9, mGPS, a longer hospital stay, complication, accompanying vein resection, larger tumor size, worse differentiation, higher TNM stage (stage IIB, III, IV), presence of LVI, and positive resection margin were risk factors for poor survival after resection. In resectable PDAC, patients with PHC had worse overall and disease-free survival than those with PBTC. However, tumor location was not an independent prognostic factor for PDAC.
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spelling pubmed-86156792021-11-26 Comparison of Characteristics and Survival Rates of Resectable Pancreatic Ductal Adenocarcinoma according to Tumor Location Sung, Min Kyu Park, Yejong Kwak, Bong Jun Jun, Eunsung Lee, Woohyung Song, Ki Byung Lee, Jae Hoon Hwang, Dae Wook Kim, Song Cheol Biomedicines Article The impact of tumor location on patient survival in pancreatic ductal adenocarcinoma (PDAC) remains controversial. This study investigated the association between primary tumor location and survival rates for resectable PDAC. Additionally, we assessed if this association remains consistent across categories of the Tumor-Node-Metastasis staging system. We analyzed 2471 patients who underwent surgical resection between 2000 and 2018 at a single center. Subgroup analysis was performed according to the Tumor-Node-Metastasis staging system. Among the group, 67.9% (1677 patients) had pancreatic head cancer (PHC) and 32.1% (794 patients) had pancreatic body/tail cancer (PBTC). Patients with PHC had worse overall survival and worse disease-free survival than those with PBTC. Patients with PHC had worse survival in stage IB and stage IIB than those with PBTC. No significant difference was observed for stages IA, IIA, and III. Multivariate analysis showed that elevated CA 19-9, mGPS, a longer hospital stay, complication, accompanying vein resection, larger tumor size, worse differentiation, higher TNM stage (stage IIB, III, IV), presence of LVI, and positive resection margin were risk factors for poor survival after resection. In resectable PDAC, patients with PHC had worse overall and disease-free survival than those with PBTC. However, tumor location was not an independent prognostic factor for PDAC. MDPI 2021-11-17 /pmc/articles/PMC8615679/ /pubmed/34829935 http://dx.doi.org/10.3390/biomedicines9111706 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sung, Min Kyu
Park, Yejong
Kwak, Bong Jun
Jun, Eunsung
Lee, Woohyung
Song, Ki Byung
Lee, Jae Hoon
Hwang, Dae Wook
Kim, Song Cheol
Comparison of Characteristics and Survival Rates of Resectable Pancreatic Ductal Adenocarcinoma according to Tumor Location
title Comparison of Characteristics and Survival Rates of Resectable Pancreatic Ductal Adenocarcinoma according to Tumor Location
title_full Comparison of Characteristics and Survival Rates of Resectable Pancreatic Ductal Adenocarcinoma according to Tumor Location
title_fullStr Comparison of Characteristics and Survival Rates of Resectable Pancreatic Ductal Adenocarcinoma according to Tumor Location
title_full_unstemmed Comparison of Characteristics and Survival Rates of Resectable Pancreatic Ductal Adenocarcinoma according to Tumor Location
title_short Comparison of Characteristics and Survival Rates of Resectable Pancreatic Ductal Adenocarcinoma according to Tumor Location
title_sort comparison of characteristics and survival rates of resectable pancreatic ductal adenocarcinoma according to tumor location
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615679/
https://www.ncbi.nlm.nih.gov/pubmed/34829935
http://dx.doi.org/10.3390/biomedicines9111706
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