Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis

Evidence of copper’s (Cu) involvement in Alzheimer’s disease (AD) is available, but information on Cu involvement in microglia and astrocytes during the course of AD has yet to be structurally discussed. This review deals with this matter in an attempt to provide an updated discussion on the role of...

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Autores principales: Pal, Amit, Rani, Isha, Pawar, Anil, Picozza, Mario, Rongioletti, Mauro, Squitti, Rosanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615684/
https://www.ncbi.nlm.nih.gov/pubmed/34827595
http://dx.doi.org/10.3390/biom11111598
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author Pal, Amit
Rani, Isha
Pawar, Anil
Picozza, Mario
Rongioletti, Mauro
Squitti, Rosanna
author_facet Pal, Amit
Rani, Isha
Pawar, Anil
Picozza, Mario
Rongioletti, Mauro
Squitti, Rosanna
author_sort Pal, Amit
collection PubMed
description Evidence of copper’s (Cu) involvement in Alzheimer’s disease (AD) is available, but information on Cu involvement in microglia and astrocytes during the course of AD has yet to be structurally discussed. This review deals with this matter in an attempt to provide an updated discussion on the role of reactive glia challenged by excess labile Cu in a wide picture that embraces all the major processes identified as playing a role in toxicity induced by an imbalance of Cu in AD.
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spelling pubmed-86156842021-11-26 Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis Pal, Amit Rani, Isha Pawar, Anil Picozza, Mario Rongioletti, Mauro Squitti, Rosanna Biomolecules Review Evidence of copper’s (Cu) involvement in Alzheimer’s disease (AD) is available, but information on Cu involvement in microglia and astrocytes during the course of AD has yet to be structurally discussed. This review deals with this matter in an attempt to provide an updated discussion on the role of reactive glia challenged by excess labile Cu in a wide picture that embraces all the major processes identified as playing a role in toxicity induced by an imbalance of Cu in AD. MDPI 2021-10-28 /pmc/articles/PMC8615684/ /pubmed/34827595 http://dx.doi.org/10.3390/biom11111598 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pal, Amit
Rani, Isha
Pawar, Anil
Picozza, Mario
Rongioletti, Mauro
Squitti, Rosanna
Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis
title Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis
title_full Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis
title_fullStr Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis
title_full_unstemmed Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis
title_short Microglia and Astrocytes in Alzheimer’s Disease in the Context of the Aberrant Copper Homeostasis Hypothesis
title_sort microglia and astrocytes in alzheimer’s disease in the context of the aberrant copper homeostasis hypothesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615684/
https://www.ncbi.nlm.nih.gov/pubmed/34827595
http://dx.doi.org/10.3390/biom11111598
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