Cargando…
Editorial of Special Issue “Multiple Sclerosis: Diagnosis and Treatment II”
The special issue on Multiple Sclerosis: Diagnosis and Treatment II, reflects advances and discoveries in the molecular and cellular mechanisms of disease, and novel laboratory techniques providing more sensitivity to diagnostic techninques and the understanding of neuroinflammation. Mitochondrial-m...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615709/ https://www.ncbi.nlm.nih.gov/pubmed/34829833 http://dx.doi.org/10.3390/biomedicines9111605 |
_version_ | 1784604170328735744 |
---|---|
author | Rivera, Victor M. |
author_facet | Rivera, Victor M. |
author_sort | Rivera, Victor M. |
collection | PubMed |
description | The special issue on Multiple Sclerosis: Diagnosis and Treatment II, reflects advances and discoveries in the molecular and cellular mechanisms of disease, and novel laboratory techniques providing more sensitivity to diagnostic techninques and the understanding of neuroinflammation. Mitochondrial-mediated apoptosis in isolated peripheral blood mononuclear cells and the role of reactive oxygen species are studied as indicators of activity of MS. In these cells, downregulation of circular and linera RNAs are reported as markers of highly active disease in MS. Progress and importance of Neurofilaments determinations in early diagnosis and as a marker of disease activity, and the analysis of the complex mechanisms and therapeutic potential of Sphingosine-1-phosphate receptor modulator are discussed. Epidemiologic observations from a highly diversified area of the world provide more insights into this important aspect of MS; discussions on the clinical challenges posed by spinal cord involvement in demyelinatind disorders and the latest aspects of pediatric onset MS, complement this fine collection of scientific papers. |
format | Online Article Text |
id | pubmed-8615709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86157092021-11-26 Editorial of Special Issue “Multiple Sclerosis: Diagnosis and Treatment II” Rivera, Victor M. Biomedicines Editorial The special issue on Multiple Sclerosis: Diagnosis and Treatment II, reflects advances and discoveries in the molecular and cellular mechanisms of disease, and novel laboratory techniques providing more sensitivity to diagnostic techninques and the understanding of neuroinflammation. Mitochondrial-mediated apoptosis in isolated peripheral blood mononuclear cells and the role of reactive oxygen species are studied as indicators of activity of MS. In these cells, downregulation of circular and linera RNAs are reported as markers of highly active disease in MS. Progress and importance of Neurofilaments determinations in early diagnosis and as a marker of disease activity, and the analysis of the complex mechanisms and therapeutic potential of Sphingosine-1-phosphate receptor modulator are discussed. Epidemiologic observations from a highly diversified area of the world provide more insights into this important aspect of MS; discussions on the clinical challenges posed by spinal cord involvement in demyelinatind disorders and the latest aspects of pediatric onset MS, complement this fine collection of scientific papers. MDPI 2021-11-03 /pmc/articles/PMC8615709/ /pubmed/34829833 http://dx.doi.org/10.3390/biomedicines9111605 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Editorial Rivera, Victor M. Editorial of Special Issue “Multiple Sclerosis: Diagnosis and Treatment II” |
title | Editorial of Special Issue “Multiple Sclerosis: Diagnosis and Treatment II” |
title_full | Editorial of Special Issue “Multiple Sclerosis: Diagnosis and Treatment II” |
title_fullStr | Editorial of Special Issue “Multiple Sclerosis: Diagnosis and Treatment II” |
title_full_unstemmed | Editorial of Special Issue “Multiple Sclerosis: Diagnosis and Treatment II” |
title_short | Editorial of Special Issue “Multiple Sclerosis: Diagnosis and Treatment II” |
title_sort | editorial of special issue “multiple sclerosis: diagnosis and treatment ii” |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615709/ https://www.ncbi.nlm.nih.gov/pubmed/34829833 http://dx.doi.org/10.3390/biomedicines9111605 |
work_keys_str_mv | AT riveravictorm editorialofspecialissuemultiplesclerosisdiagnosisandtreatmentii |