Cargando…

Association of Mutations Identified in Xanthinuria with the Function and Inhibition Mechanism of Xanthine Oxidoreductase

Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the two-step reaction from hypoxanthine to xanthine and from xanthine to uric acid in purine metabolism. XOR generally carries dehydrogenase activity (XDH) but is converted into an oxidase (XO) under various pathophysiologic conditions. The c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sekine, Mai, Okamoto, Ken, Ichida, Kimiyoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615798/ https://www.ncbi.nlm.nih.gov/pubmed/34829959 http://dx.doi.org/10.3390/biomedicines9111723

Ejemplares similares

Mutations Associated with Functional Disorder of Xanthine Oxidoreductase and Hereditary Xanthinuria in Humans
por: Ichida, Kimiyoshi, et al.
Publicado: (2012)

Allopurinol and oxypurinol differ in their strength and mechanisms of inhibition of xanthine oxidoreductase
por: Sekine, Mai, et al.
Publicado: (2023)

Xanthinuria Type 1 with a Novel Mutation in Xanthine Dehydrogenase and a Normal Endothelial Function
por: Miyazaki, Satoshi, et al.
Publicado: (2022)

Identification of a new mutation in the human xanthine dehydrogenase responsible for xanthinuria type I
por: Collazo Abal, Cristina, et al.
Publicado: (2021)

Chemical Nature and Reaction Mechanisms of the Molybdenum Cofactor of Xanthine Oxidoreductase
por: Okamoto, Ken, et al.
Publicado: (2013)

Possible Use of Non-purine Selective Xanthine Oxidoreductase Inhibitors for Prevention of Exercise-induced Acute Kidney Injury Associated with Renal Hypouricemia
por: Aizawa, Chiharu, et al.
Publicado: (2023)

Evaluation of Neuronal Protective Effects of Xanthine Oxidoreductase Inhibitors on Severe Whole-brain Ischemia in Mouse Model and Analysis of Xanthine Oxidoreductase Activity in the Mouse Brain
por: SUZUKI, Go, et al.
Publicado: (2015)

Pro-Aging Effects of Xanthine Oxidoreductase Products
por: Battelli, Maria Giulia, et al.
Publicado: (2020)

Hereditary xanthinuria in a goat
por: Vail, Krystal J., et al.
Publicado: (2019)

Xanthine Oxidoreductase Is Involved in Chondrocyte Mineralization and Expressed in Osteoarthritic Damaged Cartilage
por: Nasi, Sonia, et al.
Publicado: (2021)

Mechanistic insights into xanthine oxidoreductase from development studies of candidate drugs to treat hyperuricemia and gout
por: Nishino, Takeshi, et al.
Publicado: (2014)

Metabolic syndrome and cancer risk: The role of xanthine oxidoreductase
por: Battelli, Maria Giulia, et al.
Publicado: (2018)

Xanthine oxidoreductase: One enzyme for multiple physiological tasks
por: Bortolotti, Massimo, et al.
Publicado: (2021)

Xanthine oxidoreductase activity is correlated with hepatic steatosis
por: Yagi, Chisako, et al.
Publicado: (2022)

Discriminating Susceptibility of Xanthine Oxidoreductase Family to Metals
por: Steunou, Anne-Soisig, et al.
Publicado: (2023)

Xanthine Oxidoreductase-Derived Reactive Species: Physiological and Pathological Effects
por: Battelli, Maria Giulia, et al.
Publicado: (2016)

Hyperuricemia-Related Diseases and Xanthine Oxidoreductase (XOR) Inhibitors: An Overview
por: Chen, Changyi, et al.
Publicado: (2016)

The Role of Oxidative Stress in Hyperuricemia and Xanthine Oxidoreductase (XOR) Inhibitors
por: Liu, Ning, et al.
Publicado: (2021)

Xanthine oxidoreductase: A leading actor in cardiovascular disease drama
por: Polito, Letizia, et al.
Publicado: (2021)

Different inhibitory potency of febuxostat towards mammalian and bacterial xanthine oxidoreductases: insight from molecular dynamics
por: Kikuchi, Hiroto, et al.
Publicado: (2012)

Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice
por: Nakamura, Takashi, et al.
Publicado: (2021)

Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth
por: Kusano, Teruo, et al.
Publicado: (2019)

A frameshift mutation in MOCOS is associated with familial renal syndrome (xanthinuria) in Tyrolean Grey cattle
por: Murgiano, Leonardo, et al.
Publicado: (2016)

Putting xanthine oxidoreductase and aldehyde oxidase on the NO metabolism map: Nitrite reduction by molybdoenzymes()
por: Maia, Luisa B., et al.
Publicado: (2018)

Xanthine oxidoreductase in cancer: more than a differentiation marker
por: Battelli, Maria Giulia, et al.
Publicado: (2015)

Plasma Xanthine Oxidoreductase (XOR) Activity in Cardiovascular Disease Outpatients
por: Matsushita, Masato, et al.
Publicado: (2020)

Gender Differences in the Impact of Plasma Xanthine Oxidoreductase Activity on Coronary Artery Spasm
por: Watanabe, Ken, et al.
Publicado: (2021)

Three cases of xanthinuria identified by gas chromatography/mass spectrometry‐based urine metabolomics
por: Kuhara, Tomiko, et al.
Publicado: (2023)

Xanthine oxidoreductase gene polymorphisms are associated with high risk of sepsis and organ failure
por: Gao, Li, et al.
Publicado: (2023)

Diurnal Variations in Serum Uric Acid, Xanthine, and Xanthine Oxidoreductase Activity in Male Patients with Coronary Artery Disease
por: Shimizu, Megumi, et al.
Publicado: (2023)

Structural and Functional Insights into the Catalytic Inactivity of the Major Fraction of Buffalo Milk Xanthine Oxidoreductase
por: Gadave, Kaustubh S., et al.
Publicado: (2014)

Xanthine oxidoreductase-catalyzed reactive species generation: A process in critical need of reevaluation()
por: Cantu-Medellin, Nadiezhda, et al.
Publicado: (2013)

Inhibition of Xanthine Oxidoreductase Enhances the Potential of Tyrosine Kinase Inhibitors against Chronic Myeloid Leukemia
por: Romo-González, Marta, et al.
Publicado: (2020)

Independent links between plasma xanthine oxidoreductase activity and levels of adipokines
por: Furuhashi, Masato, et al.
Publicado: (2019)

Hydrogen sulfide stimulates xanthine oxidoreductase conversion to nitrite reductase and formation of NO
por: Pardue, Sibile, et al.
Publicado: (2020)

Impact of plasma xanthine oxidoreductase activity in patients with heart failure with preserved ejection fraction
por: Watanabe, Ken, et al.
Publicado: (2020)

Xanthine oxidoreductase activity is associated with serum uric acid and glycemic control in hemodialysis patients
por: Nakatani, Ayumi, et al.
Publicado: (2017)

The mechanism and significance of the conversion of xanthine dehydrogenase to xanthine oxidase in mammalian secretory gland cells
por: Kusano, Teruo, et al.
Publicado: (2022)

Metabolomics analysis elucidates unique influences on purine / pyrimidine metabolism by xanthine oxidoreductase inhibitors in a rat model of renal ischemia-reperfusion injury
por: Tani, Takashi, et al.
Publicado: (2019)

Hyperuricaemia, Xanthine Oxidoreductase and Ribosome-Inactivating Proteins from Plants: The Contributions of Fiorenzo Stirpe to Frontline Research
por: Bolognesi, Andrea, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_7vt4pic8n193n0in0napac6dt5