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Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal malignancy with poor survival outcomes. In addition, oxysterol-binding protein-like (OSBPL) family members are reported to be involved in lipid binding and transport and play critical roles in tumorigenesis. However, relationships between PDA...

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Autores principales: Chou, Cheng-Wei, Hsieh, Yu-Hsiu, Ku, Su-Chi, Shen, Wan-Jou, Anuraga, Gangga, Khoa Ta, Hoang Dang, Lee, Kuen-Haur, Lee, Yu-Cheng, Lin, Cheng-Hsien, Wang, Chih-Yang, Wang, Wei-Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615799/
https://www.ncbi.nlm.nih.gov/pubmed/34829830
http://dx.doi.org/10.3390/biomedicines9111601
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author Chou, Cheng-Wei
Hsieh, Yu-Hsiu
Ku, Su-Chi
Shen, Wan-Jou
Anuraga, Gangga
Khoa Ta, Hoang Dang
Lee, Kuen-Haur
Lee, Yu-Cheng
Lin, Cheng-Hsien
Wang, Chih-Yang
Wang, Wei-Jan
author_facet Chou, Cheng-Wei
Hsieh, Yu-Hsiu
Ku, Su-Chi
Shen, Wan-Jou
Anuraga, Gangga
Khoa Ta, Hoang Dang
Lee, Kuen-Haur
Lee, Yu-Cheng
Lin, Cheng-Hsien
Wang, Chih-Yang
Wang, Wei-Jan
author_sort Chou, Cheng-Wei
collection PubMed
description Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal malignancy with poor survival outcomes. In addition, oxysterol-binding protein-like (OSBPL) family members are reported to be involved in lipid binding and transport and play critical roles in tumorigenesis. However, relationships between PDAC and OSBPL family members have not comprehensively been elucidated. In this study, we used the Oncomine and GEPIA 2 databases to analyze OSBPL transcription expressions in PDAC. The Kaplan–Meier plotter and TIMER 2.0 were used to assess the relationships between overall survival (OS) and immune-infiltration with OSBPL family members. Co-expression data from cBioPortal were downloaded to assess the correlated pathways with OSBPL gene family members using DAVID. The expressions of OSBPL3, OSBPL8, OSBPL10, and OSBPL11 were found to be highly upregulated in PDAC. Low expressions of OSBPL3, OSBPL8, and OSBPL10 indicated longer OS. The functions of OSBPL family members were mainly associated with several potential signaling pathways in cancer cells, including ATP binding, integrin binding, receptor binding, and the renin-angiotensin system (RAS) signaling pathway. The transcription levels of OSBPL gene family members were connected with several immune infiltrates. Collectively, OSBPL family members are influential biomarkers for the early diagnosis of PDAC and have prognostic value, with the promise of precise treatment of PDAC in the future.
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spelling pubmed-86157992021-11-26 Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma Chou, Cheng-Wei Hsieh, Yu-Hsiu Ku, Su-Chi Shen, Wan-Jou Anuraga, Gangga Khoa Ta, Hoang Dang Lee, Kuen-Haur Lee, Yu-Cheng Lin, Cheng-Hsien Wang, Chih-Yang Wang, Wei-Jan Biomedicines Article Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal malignancy with poor survival outcomes. In addition, oxysterol-binding protein-like (OSBPL) family members are reported to be involved in lipid binding and transport and play critical roles in tumorigenesis. However, relationships between PDAC and OSBPL family members have not comprehensively been elucidated. In this study, we used the Oncomine and GEPIA 2 databases to analyze OSBPL transcription expressions in PDAC. The Kaplan–Meier plotter and TIMER 2.0 were used to assess the relationships between overall survival (OS) and immune-infiltration with OSBPL family members. Co-expression data from cBioPortal were downloaded to assess the correlated pathways with OSBPL gene family members using DAVID. The expressions of OSBPL3, OSBPL8, OSBPL10, and OSBPL11 were found to be highly upregulated in PDAC. Low expressions of OSBPL3, OSBPL8, and OSBPL10 indicated longer OS. The functions of OSBPL family members were mainly associated with several potential signaling pathways in cancer cells, including ATP binding, integrin binding, receptor binding, and the renin-angiotensin system (RAS) signaling pathway. The transcription levels of OSBPL gene family members were connected with several immune infiltrates. Collectively, OSBPL family members are influential biomarkers for the early diagnosis of PDAC and have prognostic value, with the promise of precise treatment of PDAC in the future. MDPI 2021-11-03 /pmc/articles/PMC8615799/ /pubmed/34829830 http://dx.doi.org/10.3390/biomedicines9111601 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chou, Cheng-Wei
Hsieh, Yu-Hsiu
Ku, Su-Chi
Shen, Wan-Jou
Anuraga, Gangga
Khoa Ta, Hoang Dang
Lee, Kuen-Haur
Lee, Yu-Cheng
Lin, Cheng-Hsien
Wang, Chih-Yang
Wang, Wei-Jan
Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma
title Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma
title_full Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma
title_fullStr Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma
title_full_unstemmed Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma
title_short Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma
title_sort potential prognostic biomarkers of osbpl family genes in patients with pancreatic ductal adenocarcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615799/
https://www.ncbi.nlm.nih.gov/pubmed/34829830
http://dx.doi.org/10.3390/biomedicines9111601
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