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Enhancement of the Immunostimulatory Effect of Phosphodiester CpG Oligodeoxynucleotides by an Antiparallel Guanine-Quadruplex Structural Scaffold

Guanine-quadruplex-based CpG oligodeoxynucleotides (G4 CpG ODNs) have been developed as potent immunostimulatory agents with reduced sensitivity to nucleases. We designed new monomeric G4 ODNs with an antiparallel topology using antiparallel type duplex/G4 ODNs as robust scaffolds, and we characteri...

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Detalles Bibliográficos
Autores principales:	Safitri, Fika Ayu, Tu, Anh Thi Tram, Hoshi, Kazuaki, Shobo, Miwako, Zhao, Dandan, Witarto, Arief Budi, Sumarsono, Sony Heru, Giri-Rachman, Ernawati Arifin, Tsukakoshi, Kaori, Ikebukuro, Kazunori, Yamazaki, Tomohiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615816/ https://www.ncbi.nlm.nih.gov/pubmed/34827615 http://dx.doi.org/10.3390/biom11111617

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