Cargando…

Relationship between Short-Range and Homotopic Long-Range Resting State Functional Connectivity in Temporal Lobes in Autism Spectrum Disorder

To investigate the relationship between short-range and homotopic long-range resting state functional connectivity (RSFC) in children with autism spectrum disorder (ASD) and typically developing (TD) children, we analyzed functional near-infrared spectroscopy (fNIRS) RSFC in 25 children with ASD and...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Xiaoyin, Lin, Fang, Sun, Weiting, Zhang, Tingzhen, Sun, Huiwen, Li, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615873/
https://www.ncbi.nlm.nih.gov/pubmed/34827466
http://dx.doi.org/10.3390/brainsci11111467
_version_ 1784604210856198144
author Wu, Xiaoyin
Lin, Fang
Sun, Weiting
Zhang, Tingzhen
Sun, Huiwen
Li, Jun
author_facet Wu, Xiaoyin
Lin, Fang
Sun, Weiting
Zhang, Tingzhen
Sun, Huiwen
Li, Jun
author_sort Wu, Xiaoyin
collection PubMed
description To investigate the relationship between short-range and homotopic long-range resting state functional connectivity (RSFC) in children with autism spectrum disorder (ASD) and typically developing (TD) children, we analyzed functional near-infrared spectroscopy (fNIRS) RSFC in 25 children with ASD and 22 age-matched TD children. The resting state fNIRS signals, including spontaneous fluctuations in the oxygenated hemoglobin (HbO(2)) and deoxygenated hemoglobin (Hb) concentrations, were recorded from the bilateral temporal lobes. We found that (1) there was no difference in the short-range RSFC between the left and right hemisphere in either ASD or TD group; (2) both the short-range and homotopic long-range RSFC were weaker in the ASD than TD group; and (3) the short-range RSFC was stronger than the homotopic long-range RSFC in the ASD group, whereas no such difference was observed in the TD group. These observations might be helpful for a better understanding of the underlying cortical mechanism in ASD.
format Online
Article
Text
id pubmed-8615873
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86158732021-11-26 Relationship between Short-Range and Homotopic Long-Range Resting State Functional Connectivity in Temporal Lobes in Autism Spectrum Disorder Wu, Xiaoyin Lin, Fang Sun, Weiting Zhang, Tingzhen Sun, Huiwen Li, Jun Brain Sci Article To investigate the relationship between short-range and homotopic long-range resting state functional connectivity (RSFC) in children with autism spectrum disorder (ASD) and typically developing (TD) children, we analyzed functional near-infrared spectroscopy (fNIRS) RSFC in 25 children with ASD and 22 age-matched TD children. The resting state fNIRS signals, including spontaneous fluctuations in the oxygenated hemoglobin (HbO(2)) and deoxygenated hemoglobin (Hb) concentrations, were recorded from the bilateral temporal lobes. We found that (1) there was no difference in the short-range RSFC between the left and right hemisphere in either ASD or TD group; (2) both the short-range and homotopic long-range RSFC were weaker in the ASD than TD group; and (3) the short-range RSFC was stronger than the homotopic long-range RSFC in the ASD group, whereas no such difference was observed in the TD group. These observations might be helpful for a better understanding of the underlying cortical mechanism in ASD. MDPI 2021-11-05 /pmc/articles/PMC8615873/ /pubmed/34827466 http://dx.doi.org/10.3390/brainsci11111467 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Xiaoyin
Lin, Fang
Sun, Weiting
Zhang, Tingzhen
Sun, Huiwen
Li, Jun
Relationship between Short-Range and Homotopic Long-Range Resting State Functional Connectivity in Temporal Lobes in Autism Spectrum Disorder
title Relationship between Short-Range and Homotopic Long-Range Resting State Functional Connectivity in Temporal Lobes in Autism Spectrum Disorder
title_full Relationship between Short-Range and Homotopic Long-Range Resting State Functional Connectivity in Temporal Lobes in Autism Spectrum Disorder
title_fullStr Relationship between Short-Range and Homotopic Long-Range Resting State Functional Connectivity in Temporal Lobes in Autism Spectrum Disorder
title_full_unstemmed Relationship between Short-Range and Homotopic Long-Range Resting State Functional Connectivity in Temporal Lobes in Autism Spectrum Disorder
title_short Relationship between Short-Range and Homotopic Long-Range Resting State Functional Connectivity in Temporal Lobes in Autism Spectrum Disorder
title_sort relationship between short-range and homotopic long-range resting state functional connectivity in temporal lobes in autism spectrum disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615873/
https://www.ncbi.nlm.nih.gov/pubmed/34827466
http://dx.doi.org/10.3390/brainsci11111467
work_keys_str_mv AT wuxiaoyin relationshipbetweenshortrangeandhomotopiclongrangerestingstatefunctionalconnectivityintemporallobesinautismspectrumdisorder
AT linfang relationshipbetweenshortrangeandhomotopiclongrangerestingstatefunctionalconnectivityintemporallobesinautismspectrumdisorder
AT sunweiting relationshipbetweenshortrangeandhomotopiclongrangerestingstatefunctionalconnectivityintemporallobesinautismspectrumdisorder
AT zhangtingzhen relationshipbetweenshortrangeandhomotopiclongrangerestingstatefunctionalconnectivityintemporallobesinautismspectrumdisorder
AT sunhuiwen relationshipbetweenshortrangeandhomotopiclongrangerestingstatefunctionalconnectivityintemporallobesinautismspectrumdisorder
AT lijun relationshipbetweenshortrangeandhomotopiclongrangerestingstatefunctionalconnectivityintemporallobesinautismspectrumdisorder