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The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target

Endometriosis is a condition that is influenced by hormones and involves stroma and glands being found outside the uterus; there are increases in proliferation, invasion, internal bleeding, and fibrosis. Matrix metalloproteinases (MMPs) have been suggested to be crucial in the progression of invasio...

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Autores principales: Ke, Junya, Ye, Jiangfeng, Li, Mingqing, Zhu, Zhiling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615881/
https://www.ncbi.nlm.nih.gov/pubmed/34827737
http://dx.doi.org/10.3390/biom11111739
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author Ke, Junya
Ye, Jiangfeng
Li, Mingqing
Zhu, Zhiling
author_facet Ke, Junya
Ye, Jiangfeng
Li, Mingqing
Zhu, Zhiling
author_sort Ke, Junya
collection PubMed
description Endometriosis is a condition that is influenced by hormones and involves stroma and glands being found outside the uterus; there are increases in proliferation, invasion, internal bleeding, and fibrosis. Matrix metalloproteinases (MMPs) have been suggested to be crucial in the progression of invasion. The MMP family includes calcium-dependent zinc-containing endopeptidases, some of which not only affect the process of cell invasion but also participate in other physiological and pathological processes, such as angiogenesis and fibrosis. MMPs act as downstream-targeted molecules and their expression can be regulated by numerous factors such as estrogen, oxidative stress, cytokines, and environmental contaminants. Given their unique roles in endometriosis, MMPs may become effective biomarkers of endometriosis in the future. In the present review, we summarize the current literature on MMPs regarding their classification, function, and potential value for endometriosis, which may contribute to our knowledge of MMPs and MMP-targeted interventions.
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spelling pubmed-86158812021-11-26 The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target Ke, Junya Ye, Jiangfeng Li, Mingqing Zhu, Zhiling Biomolecules Review Endometriosis is a condition that is influenced by hormones and involves stroma and glands being found outside the uterus; there are increases in proliferation, invasion, internal bleeding, and fibrosis. Matrix metalloproteinases (MMPs) have been suggested to be crucial in the progression of invasion. The MMP family includes calcium-dependent zinc-containing endopeptidases, some of which not only affect the process of cell invasion but also participate in other physiological and pathological processes, such as angiogenesis and fibrosis. MMPs act as downstream-targeted molecules and their expression can be regulated by numerous factors such as estrogen, oxidative stress, cytokines, and environmental contaminants. Given their unique roles in endometriosis, MMPs may become effective biomarkers of endometriosis in the future. In the present review, we summarize the current literature on MMPs regarding their classification, function, and potential value for endometriosis, which may contribute to our knowledge of MMPs and MMP-targeted interventions. MDPI 2021-11-22 /pmc/articles/PMC8615881/ /pubmed/34827737 http://dx.doi.org/10.3390/biom11111739 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ke, Junya
Ye, Jiangfeng
Li, Mingqing
Zhu, Zhiling
The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target
title The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target
title_full The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target
title_fullStr The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target
title_full_unstemmed The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target
title_short The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target
title_sort role of matrix metalloproteinases in endometriosis: a potential target
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615881/
https://www.ncbi.nlm.nih.gov/pubmed/34827737
http://dx.doi.org/10.3390/biom11111739
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