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Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy

Corpus callosotomy (CC) is an established palliative surgery for human patients with drug-resistant epilepsy (DRE), especially those with generalized seizures and multiple or unknown epileptogenic focus. However, there are no reports to describe CC in canine patients with epilepsy. Three client-owne...

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Autores principales: Asada, Rikako, Mizuno, Satoshi, Yu, Yoshihiko, Hamamoto, Yuji, Anazawa, Tetsuya, Ito, Daisuke, Kitagawa, Masato, Hasegawa, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615928/
https://www.ncbi.nlm.nih.gov/pubmed/34827461
http://dx.doi.org/10.3390/brainsci11111462
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author Asada, Rikako
Mizuno, Satoshi
Yu, Yoshihiko
Hamamoto, Yuji
Anazawa, Tetsuya
Ito, Daisuke
Kitagawa, Masato
Hasegawa, Daisuke
author_facet Asada, Rikako
Mizuno, Satoshi
Yu, Yoshihiko
Hamamoto, Yuji
Anazawa, Tetsuya
Ito, Daisuke
Kitagawa, Masato
Hasegawa, Daisuke
author_sort Asada, Rikako
collection PubMed
description Corpus callosotomy (CC) is an established palliative surgery for human patients with drug-resistant epilepsy (DRE), especially those with generalized seizures and multiple or unknown epileptogenic focus. However, there are no reports to describe CC in canine patients with epilepsy. Three client-owned Cavalier King Charles Spaniels with DRE are included in this case series. In presurgical evaluations, an apparent epileptogenic zone was not detected in each dog and CC was conducted. Total CC was performed in one dog, whereas the other two received partial CC. One dog recovered from surgery without any complications, but died suddenly by an unknown cause at 10 h after surgery. For the other two dogs, postoperative evaluations including seizure outcomes, complications, and quality of life of the dogs and owners were assessed for at least 12 months. Both dogs showed a remarkable decrease in seizure frequency (averaged 80.3% reduction) and severity after surgery. The antiseizure medications were maintained, and not only the mentation and activity of the dogs, but also the quality of life of dogs and owners were improved postoperatively. Although technical improvement and more large-scale studies are needed, CC is a treatment option for dogs with DRE in veterinary medicine.
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spelling pubmed-86159282021-11-26 Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy Asada, Rikako Mizuno, Satoshi Yu, Yoshihiko Hamamoto, Yuji Anazawa, Tetsuya Ito, Daisuke Kitagawa, Masato Hasegawa, Daisuke Brain Sci Case Report Corpus callosotomy (CC) is an established palliative surgery for human patients with drug-resistant epilepsy (DRE), especially those with generalized seizures and multiple or unknown epileptogenic focus. However, there are no reports to describe CC in canine patients with epilepsy. Three client-owned Cavalier King Charles Spaniels with DRE are included in this case series. In presurgical evaluations, an apparent epileptogenic zone was not detected in each dog and CC was conducted. Total CC was performed in one dog, whereas the other two received partial CC. One dog recovered from surgery without any complications, but died suddenly by an unknown cause at 10 h after surgery. For the other two dogs, postoperative evaluations including seizure outcomes, complications, and quality of life of the dogs and owners were assessed for at least 12 months. Both dogs showed a remarkable decrease in seizure frequency (averaged 80.3% reduction) and severity after surgery. The antiseizure medications were maintained, and not only the mentation and activity of the dogs, but also the quality of life of dogs and owners were improved postoperatively. Although technical improvement and more large-scale studies are needed, CC is a treatment option for dogs with DRE in veterinary medicine. MDPI 2021-11-04 /pmc/articles/PMC8615928/ /pubmed/34827461 http://dx.doi.org/10.3390/brainsci11111462 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Asada, Rikako
Mizuno, Satoshi
Yu, Yoshihiko
Hamamoto, Yuji
Anazawa, Tetsuya
Ito, Daisuke
Kitagawa, Masato
Hasegawa, Daisuke
Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy
title Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy
title_full Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy
title_fullStr Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy
title_full_unstemmed Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy
title_short Corpus Callosotomy in 3 Cavalier King Charles Spaniel Dogs with Drug-Resistant Epilepsy
title_sort corpus callosotomy in 3 cavalier king charles spaniel dogs with drug-resistant epilepsy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615928/
https://www.ncbi.nlm.nih.gov/pubmed/34827461
http://dx.doi.org/10.3390/brainsci11111462
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