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The Number or Type of Stimuli Used for Somatosensory Stimulation Affected the Modulation of Corticospinal Excitability

Motor evoked potentials (MEPs) evoked by transcranial magnetic stimulation (TMS) a few milliseconds after this cortical activity following electrical stimulation (ES) result in an inhibition comparable to that by TMS alone; this is called short-latency afferent inhibition (SAI). Cortical activity is...

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Autores principales: Kojima, Sho, Miyaguchi, Shota, Yokota, Hirotake, Saito, Kei, Inukai, Yasuto, Otsuru, Naofumi, Onishi, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615945/
https://www.ncbi.nlm.nih.gov/pubmed/34827493
http://dx.doi.org/10.3390/brainsci11111494
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author Kojima, Sho
Miyaguchi, Shota
Yokota, Hirotake
Saito, Kei
Inukai, Yasuto
Otsuru, Naofumi
Onishi, Hideaki
author_facet Kojima, Sho
Miyaguchi, Shota
Yokota, Hirotake
Saito, Kei
Inukai, Yasuto
Otsuru, Naofumi
Onishi, Hideaki
author_sort Kojima, Sho
collection PubMed
description Motor evoked potentials (MEPs) evoked by transcranial magnetic stimulation (TMS) a few milliseconds after this cortical activity following electrical stimulation (ES) result in an inhibition comparable to that by TMS alone; this is called short-latency afferent inhibition (SAI). Cortical activity is observed after mechanical tactile stimulation (MS) and is affected by the number of stimuli by ES. We determined the effects of somatosensory stimulus methods and multiple conditioning stimuli on SAI in 19 participants. In experiment 1, the interstimulus intervals between the conditioning stimulation and TMS were 25, 27 and 29 ms for ES and 28, 30 and 32 ms for MS. In experiment 2, we used 1, 2, 3 and 4 conditioning stimulations of ES and MS. The interstimulus interval between the ES or MS and TMS was 27 or 30 ms, respectively. In experiment 1, MEPs were significantly decreased in both the ES and MS conditions. In experiment 2, MEPs after ES were significantly decreased in all conditions. Conversely, MEPs after MS were significantly decreased after one stimulus and increased after four stimulations, indicating the SAI according to the number of stimuli. Therefore, the somatosensory stimulus methods and multiple conditioning stimuli affected the SAI.
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spelling pubmed-86159452021-11-26 The Number or Type of Stimuli Used for Somatosensory Stimulation Affected the Modulation of Corticospinal Excitability Kojima, Sho Miyaguchi, Shota Yokota, Hirotake Saito, Kei Inukai, Yasuto Otsuru, Naofumi Onishi, Hideaki Brain Sci Article Motor evoked potentials (MEPs) evoked by transcranial magnetic stimulation (TMS) a few milliseconds after this cortical activity following electrical stimulation (ES) result in an inhibition comparable to that by TMS alone; this is called short-latency afferent inhibition (SAI). Cortical activity is observed after mechanical tactile stimulation (MS) and is affected by the number of stimuli by ES. We determined the effects of somatosensory stimulus methods and multiple conditioning stimuli on SAI in 19 participants. In experiment 1, the interstimulus intervals between the conditioning stimulation and TMS were 25, 27 and 29 ms for ES and 28, 30 and 32 ms for MS. In experiment 2, we used 1, 2, 3 and 4 conditioning stimulations of ES and MS. The interstimulus interval between the ES or MS and TMS was 27 or 30 ms, respectively. In experiment 1, MEPs were significantly decreased in both the ES and MS conditions. In experiment 2, MEPs after ES were significantly decreased in all conditions. Conversely, MEPs after MS were significantly decreased after one stimulus and increased after four stimulations, indicating the SAI according to the number of stimuli. Therefore, the somatosensory stimulus methods and multiple conditioning stimuli affected the SAI. MDPI 2021-11-12 /pmc/articles/PMC8615945/ /pubmed/34827493 http://dx.doi.org/10.3390/brainsci11111494 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kojima, Sho
Miyaguchi, Shota
Yokota, Hirotake
Saito, Kei
Inukai, Yasuto
Otsuru, Naofumi
Onishi, Hideaki
The Number or Type of Stimuli Used for Somatosensory Stimulation Affected the Modulation of Corticospinal Excitability
title The Number or Type of Stimuli Used for Somatosensory Stimulation Affected the Modulation of Corticospinal Excitability
title_full The Number or Type of Stimuli Used for Somatosensory Stimulation Affected the Modulation of Corticospinal Excitability
title_fullStr The Number or Type of Stimuli Used for Somatosensory Stimulation Affected the Modulation of Corticospinal Excitability
title_full_unstemmed The Number or Type of Stimuli Used for Somatosensory Stimulation Affected the Modulation of Corticospinal Excitability
title_short The Number or Type of Stimuli Used for Somatosensory Stimulation Affected the Modulation of Corticospinal Excitability
title_sort number or type of stimuli used for somatosensory stimulation affected the modulation of corticospinal excitability
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615945/
https://www.ncbi.nlm.nih.gov/pubmed/34827493
http://dx.doi.org/10.3390/brainsci11111494
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