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The Genetic Profile and Serum Level of IL-8 Are Associated with Chronic Hepatitis B and C Virus Infection

The present study evaluated the IL8-251 A/T polymorphism in samples from 74 patients with chronic hepatitis B (HBV), 100 patients with chronic hepatitis C (HCV), and 300 healthy donors (CG). The correlations of this polymorphism with plasma IL-8 and disease stage were calculated. Polymorphisms were...

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Autores principales: Amoras, Ednelza da Silva Graça, de Brito, William Botelho, Queiroz, Maria Alice Freitas, Conde, Simone Regina Souza da Silva, Cayres Vallinoto, Izaura Maria Vieira, Ishak, Ricardo, Vallinoto, Antonio Carlos Rosário
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615951/
https://www.ncbi.nlm.nih.gov/pubmed/34827662
http://dx.doi.org/10.3390/biom11111664
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author Amoras, Ednelza da Silva Graça
de Brito, William Botelho
Queiroz, Maria Alice Freitas
Conde, Simone Regina Souza da Silva
Cayres Vallinoto, Izaura Maria Vieira
Ishak, Ricardo
Vallinoto, Antonio Carlos Rosário
author_facet Amoras, Ednelza da Silva Graça
de Brito, William Botelho
Queiroz, Maria Alice Freitas
Conde, Simone Regina Souza da Silva
Cayres Vallinoto, Izaura Maria Vieira
Ishak, Ricardo
Vallinoto, Antonio Carlos Rosário
author_sort Amoras, Ednelza da Silva Graça
collection PubMed
description The present study evaluated the IL8-251 A/T polymorphism in samples from 74 patients with chronic hepatitis B (HBV), 100 patients with chronic hepatitis C (HCV), and 300 healthy donors (CG). The correlations of this polymorphism with plasma IL-8 and disease stage were calculated. Polymorphisms were identified by real-time PCR. IL-8 was measured by enzyme-linked immunosorbent assay. The IL8-251 A/T genotype was not associated with susceptibility to infection by HBV or HCV. The wild-type allele (A) was associated with higher levels of inflammation (p = 0.0464) and fibrosis scores (p = 0.0016) in the HBV group, representing an increased risk for increased inflammatory activity (OR = 1.84; p = 0.0464) and for high fibrosis scores (OR = 2.63; p = 0.0016). Viral load was higher in HBV patients with polymorphic genotypes (TA and TT) at the IL8-251 A/T polymorphism than in those with the wild-type genotype (p = 0.0272 and p = 0.0464, respectively). Plasma IL-8 was higher among patients infected with HBV or HCV than in the control group (p = 0.0445 and p = 0.0001, respectively). The polymorphic genotype was associated with lower IL-8 than the wild-type genotype in the HBV group (p = 0.0239) and the HCV group (p = 0.0372). The wild-type genotype for IL8-251 A/T and high IL-8 were associated with a worse prognosis for infections; therefore, they may contribute to viral persistence and the development of more severe forms of chronic viral liver diseases.
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spelling pubmed-86159512021-11-26 The Genetic Profile and Serum Level of IL-8 Are Associated with Chronic Hepatitis B and C Virus Infection Amoras, Ednelza da Silva Graça de Brito, William Botelho Queiroz, Maria Alice Freitas Conde, Simone Regina Souza da Silva Cayres Vallinoto, Izaura Maria Vieira Ishak, Ricardo Vallinoto, Antonio Carlos Rosário Biomolecules Article The present study evaluated the IL8-251 A/T polymorphism in samples from 74 patients with chronic hepatitis B (HBV), 100 patients with chronic hepatitis C (HCV), and 300 healthy donors (CG). The correlations of this polymorphism with plasma IL-8 and disease stage were calculated. Polymorphisms were identified by real-time PCR. IL-8 was measured by enzyme-linked immunosorbent assay. The IL8-251 A/T genotype was not associated with susceptibility to infection by HBV or HCV. The wild-type allele (A) was associated with higher levels of inflammation (p = 0.0464) and fibrosis scores (p = 0.0016) in the HBV group, representing an increased risk for increased inflammatory activity (OR = 1.84; p = 0.0464) and for high fibrosis scores (OR = 2.63; p = 0.0016). Viral load was higher in HBV patients with polymorphic genotypes (TA and TT) at the IL8-251 A/T polymorphism than in those with the wild-type genotype (p = 0.0272 and p = 0.0464, respectively). Plasma IL-8 was higher among patients infected with HBV or HCV than in the control group (p = 0.0445 and p = 0.0001, respectively). The polymorphic genotype was associated with lower IL-8 than the wild-type genotype in the HBV group (p = 0.0239) and the HCV group (p = 0.0372). The wild-type genotype for IL8-251 A/T and high IL-8 were associated with a worse prognosis for infections; therefore, they may contribute to viral persistence and the development of more severe forms of chronic viral liver diseases. MDPI 2021-11-10 /pmc/articles/PMC8615951/ /pubmed/34827662 http://dx.doi.org/10.3390/biom11111664 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Amoras, Ednelza da Silva Graça
de Brito, William Botelho
Queiroz, Maria Alice Freitas
Conde, Simone Regina Souza da Silva
Cayres Vallinoto, Izaura Maria Vieira
Ishak, Ricardo
Vallinoto, Antonio Carlos Rosário
The Genetic Profile and Serum Level of IL-8 Are Associated with Chronic Hepatitis B and C Virus Infection
title The Genetic Profile and Serum Level of IL-8 Are Associated with Chronic Hepatitis B and C Virus Infection
title_full The Genetic Profile and Serum Level of IL-8 Are Associated with Chronic Hepatitis B and C Virus Infection
title_fullStr The Genetic Profile and Serum Level of IL-8 Are Associated with Chronic Hepatitis B and C Virus Infection
title_full_unstemmed The Genetic Profile and Serum Level of IL-8 Are Associated with Chronic Hepatitis B and C Virus Infection
title_short The Genetic Profile and Serum Level of IL-8 Are Associated with Chronic Hepatitis B and C Virus Infection
title_sort genetic profile and serum level of il-8 are associated with chronic hepatitis b and c virus infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615951/
https://www.ncbi.nlm.nih.gov/pubmed/34827662
http://dx.doi.org/10.3390/biom11111664
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