ATP and Tri-Polyphosphate (TPP) Suppress Protein Aggregate Growth by a Supercharging Mechanism

A common strategy to increase aggregation resistance is through rational mutagenesis to supercharge proteins, which leads to high colloidal stability, but often has the undesirable effect of lowering conformational stability. We show this trade-off can be overcome by using small multivalent polyphos...

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Detalles Bibliográficos
Autores principales: Bye, Jordan, Murray, Kiah, Curtis, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616003/
https://www.ncbi.nlm.nih.gov/pubmed/34829875
http://dx.doi.org/10.3390/biomedicines9111646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616003/
https://www.ncbi.nlm.nih.gov/pubmed/34829875
http://dx.doi.org/10.3390/biomedicines9111646

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