The Unique Properties of Placental Mesenchymal Stromal Cells: A Novel Source of Therapy for Congenital and Acquired Spinal Cord Injury

Spinal cord injury (SCI) is a devasting condition with no reliable treatment. Spina bifida is the most common cause of congenital SCI. Cell-based therapies using mesenchymal stem/stromal cells (MSCS) have been largely utilized in SCI. Several clinical trials for acquired SCI use adult tissue-derived...

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Autores principales: Kulubya, Edwin S, Clark, Kaitlin, Hao, Dake, Lazar, Sabrina, Ghaffari-Rafi, Arash, Karnati, Tejas, Ebinu, Julius Okudu, Zwienenberg, Marike, Farmer, Diana L, Wang, Aijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616037/
https://www.ncbi.nlm.nih.gov/pubmed/34831060
http://dx.doi.org/10.3390/cells10112837
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author Kulubya, Edwin S
Clark, Kaitlin
Hao, Dake
Lazar, Sabrina
Ghaffari-Rafi, Arash
Karnati, Tejas
Ebinu, Julius Okudu
Zwienenberg, Marike
Farmer, Diana L
Wang, Aijun
author_facet Kulubya, Edwin S
Clark, Kaitlin
Hao, Dake
Lazar, Sabrina
Ghaffari-Rafi, Arash
Karnati, Tejas
Ebinu, Julius Okudu
Zwienenberg, Marike
Farmer, Diana L
Wang, Aijun
author_sort Kulubya, Edwin S
collection PubMed
description Spinal cord injury (SCI) is a devasting condition with no reliable treatment. Spina bifida is the most common cause of congenital SCI. Cell-based therapies using mesenchymal stem/stromal cells (MSCS) have been largely utilized in SCI. Several clinical trials for acquired SCI use adult tissue-derived MSC sources, including bone-marrow, adipose, and umbilical cord tissues. The first stem/stromal cell clinical trial for spina bifida is currently underway (NCT04652908). The trial uses early gestational placental-derived mesenchymal stem/stromal cells (PMSCs) during the fetal repair of myelomeningocele. PMSCs have been shown to exhibit unique neuroprotective, angiogenic, and antioxidant properties, all which are promising applications for SCI. This review will summarize the unique properties and current applications of PMSCs and discuss their therapeutic role for acquired SCI.
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spelling pubmed-86160372021-11-26 The Unique Properties of Placental Mesenchymal Stromal Cells: A Novel Source of Therapy for Congenital and Acquired Spinal Cord Injury Kulubya, Edwin S Clark, Kaitlin Hao, Dake Lazar, Sabrina Ghaffari-Rafi, Arash Karnati, Tejas Ebinu, Julius Okudu Zwienenberg, Marike Farmer, Diana L Wang, Aijun Cells Review Spinal cord injury (SCI) is a devasting condition with no reliable treatment. Spina bifida is the most common cause of congenital SCI. Cell-based therapies using mesenchymal stem/stromal cells (MSCS) have been largely utilized in SCI. Several clinical trials for acquired SCI use adult tissue-derived MSC sources, including bone-marrow, adipose, and umbilical cord tissues. The first stem/stromal cell clinical trial for spina bifida is currently underway (NCT04652908). The trial uses early gestational placental-derived mesenchymal stem/stromal cells (PMSCs) during the fetal repair of myelomeningocele. PMSCs have been shown to exhibit unique neuroprotective, angiogenic, and antioxidant properties, all which are promising applications for SCI. This review will summarize the unique properties and current applications of PMSCs and discuss their therapeutic role for acquired SCI. MDPI 2021-10-22 /pmc/articles/PMC8616037/ /pubmed/34831060 http://dx.doi.org/10.3390/cells10112837 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kulubya, Edwin S
Clark, Kaitlin
Hao, Dake
Lazar, Sabrina
Ghaffari-Rafi, Arash
Karnati, Tejas
Ebinu, Julius Okudu
Zwienenberg, Marike
Farmer, Diana L
Wang, Aijun
The Unique Properties of Placental Mesenchymal Stromal Cells: A Novel Source of Therapy for Congenital and Acquired Spinal Cord Injury
title The Unique Properties of Placental Mesenchymal Stromal Cells: A Novel Source of Therapy for Congenital and Acquired Spinal Cord Injury
title_full The Unique Properties of Placental Mesenchymal Stromal Cells: A Novel Source of Therapy for Congenital and Acquired Spinal Cord Injury
title_fullStr The Unique Properties of Placental Mesenchymal Stromal Cells: A Novel Source of Therapy for Congenital and Acquired Spinal Cord Injury
title_full_unstemmed The Unique Properties of Placental Mesenchymal Stromal Cells: A Novel Source of Therapy for Congenital and Acquired Spinal Cord Injury
title_short The Unique Properties of Placental Mesenchymal Stromal Cells: A Novel Source of Therapy for Congenital and Acquired Spinal Cord Injury
title_sort unique properties of placental mesenchymal stromal cells: a novel source of therapy for congenital and acquired spinal cord injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616037/
https://www.ncbi.nlm.nih.gov/pubmed/34831060
http://dx.doi.org/10.3390/cells10112837
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