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The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis

SIMPLE SUMMARY: A feature of pancreatic cancer (PC) is the frequent overexpression of tyrosine kinase membrane receptor HER2 along with its membrane partner the MUC4 oncomucin in the early stages of the pancreatic carcinogenesis. However, therapeutic approaches targeting HER2 in PC are not efficient...

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Detalles Bibliográficos
Autores principales:	Stoup, Nicolas, Liberelle, Maxime, Schulz, Céline, Cavdarli, Sumeyye, Vasseur, Romain, Magnez, Romain, Lahdaoui, Fatima, Skrypek, Nicolas, Peretti, Fabien, Frénois, Frédéric, Thuru, Xavier, Melnyk, Patricia, Renault, Nicolas, Jonckheere, Nicolas, Lebègue, Nicolas, Van Seuningen, Isabelle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616066/ https://www.ncbi.nlm.nih.gov/pubmed/34830899 http://dx.doi.org/10.3390/cancers13225746

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