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Multimodal Imaging-Based Potential Visualization of the Tumor Microenvironment in Bone Metastasis

Bone metastasis (BM) is the most common malignant bone tumor and a significant cause of morbidity and mortality for patients with cancer. Compared to other metastatic organs, bone has unique characteristics in terms of the tumor microenvironment (TME). Precise assessments of the TME in BM could be a...

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Autores principales: Moon, Jang Bae, Yoo, Su Woong, Lee, Changho, Kim, Dong-Yeon, Pyo, Ayoung, Kwon, Seong Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616082/
https://www.ncbi.nlm.nih.gov/pubmed/34831100
http://dx.doi.org/10.3390/cells10112877
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author Moon, Jang Bae
Yoo, Su Woong
Lee, Changho
Kim, Dong-Yeon
Pyo, Ayoung
Kwon, Seong Young
author_facet Moon, Jang Bae
Yoo, Su Woong
Lee, Changho
Kim, Dong-Yeon
Pyo, Ayoung
Kwon, Seong Young
author_sort Moon, Jang Bae
collection PubMed
description Bone metastasis (BM) is the most common malignant bone tumor and a significant cause of morbidity and mortality for patients with cancer. Compared to other metastatic organs, bone has unique characteristics in terms of the tumor microenvironment (TME). Precise assessments of the TME in BM could be an important step for developing an optimized management plan for patient care. Imaging approaches for BM have several advantages, such as biopsy not being required, multiple site evaluation, and serial assessment in the same sites. Owing to the developments of new imaging tracers or imaging modalities, bone TME could be visualized using multimodal imaging techniques. In this review, we describe the BM pathophysiology, diagnostic principles of major imaging modalities, and clinically available imaging modalities to visualize the TME in BM. We also discuss how the interactions between various factors affecting the TME could be visualized using multimodal imaging techniques.
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spelling pubmed-86160822021-11-26 Multimodal Imaging-Based Potential Visualization of the Tumor Microenvironment in Bone Metastasis Moon, Jang Bae Yoo, Su Woong Lee, Changho Kim, Dong-Yeon Pyo, Ayoung Kwon, Seong Young Cells Review Bone metastasis (BM) is the most common malignant bone tumor and a significant cause of morbidity and mortality for patients with cancer. Compared to other metastatic organs, bone has unique characteristics in terms of the tumor microenvironment (TME). Precise assessments of the TME in BM could be an important step for developing an optimized management plan for patient care. Imaging approaches for BM have several advantages, such as biopsy not being required, multiple site evaluation, and serial assessment in the same sites. Owing to the developments of new imaging tracers or imaging modalities, bone TME could be visualized using multimodal imaging techniques. In this review, we describe the BM pathophysiology, diagnostic principles of major imaging modalities, and clinically available imaging modalities to visualize the TME in BM. We also discuss how the interactions between various factors affecting the TME could be visualized using multimodal imaging techniques. MDPI 2021-10-25 /pmc/articles/PMC8616082/ /pubmed/34831100 http://dx.doi.org/10.3390/cells10112877 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Moon, Jang Bae
Yoo, Su Woong
Lee, Changho
Kim, Dong-Yeon
Pyo, Ayoung
Kwon, Seong Young
Multimodal Imaging-Based Potential Visualization of the Tumor Microenvironment in Bone Metastasis
title Multimodal Imaging-Based Potential Visualization of the Tumor Microenvironment in Bone Metastasis
title_full Multimodal Imaging-Based Potential Visualization of the Tumor Microenvironment in Bone Metastasis
title_fullStr Multimodal Imaging-Based Potential Visualization of the Tumor Microenvironment in Bone Metastasis
title_full_unstemmed Multimodal Imaging-Based Potential Visualization of the Tumor Microenvironment in Bone Metastasis
title_short Multimodal Imaging-Based Potential Visualization of the Tumor Microenvironment in Bone Metastasis
title_sort multimodal imaging-based potential visualization of the tumor microenvironment in bone metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616082/
https://www.ncbi.nlm.nih.gov/pubmed/34831100
http://dx.doi.org/10.3390/cells10112877
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