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The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins

Exposure to sub-lethal doses of ionising and non-ionising electromagnetic radiation can impact human health and well-being as a consequence of, for example, the side effects of radiotherapy (therapeutic X-ray exposure) and accelerated skin ageing (chronic exposure to ultraviolet radiation: UVR). Whi...

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Autores principales: Tuieng, Ren Jie, Cartmell, Sarah H., Kirwan, Cliona C., Sherratt, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616186/
https://www.ncbi.nlm.nih.gov/pubmed/34831262
http://dx.doi.org/10.3390/cells10113041
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author Tuieng, Ren Jie
Cartmell, Sarah H.
Kirwan, Cliona C.
Sherratt, Michael J.
author_facet Tuieng, Ren Jie
Cartmell, Sarah H.
Kirwan, Cliona C.
Sherratt, Michael J.
author_sort Tuieng, Ren Jie
collection PubMed
description Exposure to sub-lethal doses of ionising and non-ionising electromagnetic radiation can impact human health and well-being as a consequence of, for example, the side effects of radiotherapy (therapeutic X-ray exposure) and accelerated skin ageing (chronic exposure to ultraviolet radiation: UVR). Whilst attention has focused primarily on the interaction of electromagnetic radiation with cells and cellular components, radiation-induced damage to long-lived extracellular matrix (ECM) proteins has the potential to profoundly affect tissue structure, composition and function. This review focuses on the current understanding of the biological effects of ionising and non-ionising radiation on the ECM of breast stroma and skin dermis, respectively. Although there is some experimental evidence for radiation-induced damage to ECM proteins, compared with the well-characterised impact of radiation exposure on cell biology, the structural, functional, and ultimately clinical consequences of ECM irradiation remain poorly defined.
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spelling pubmed-86161862021-11-26 The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins Tuieng, Ren Jie Cartmell, Sarah H. Kirwan, Cliona C. Sherratt, Michael J. Cells Review Exposure to sub-lethal doses of ionising and non-ionising electromagnetic radiation can impact human health and well-being as a consequence of, for example, the side effects of radiotherapy (therapeutic X-ray exposure) and accelerated skin ageing (chronic exposure to ultraviolet radiation: UVR). Whilst attention has focused primarily on the interaction of electromagnetic radiation with cells and cellular components, radiation-induced damage to long-lived extracellular matrix (ECM) proteins has the potential to profoundly affect tissue structure, composition and function. This review focuses on the current understanding of the biological effects of ionising and non-ionising radiation on the ECM of breast stroma and skin dermis, respectively. Although there is some experimental evidence for radiation-induced damage to ECM proteins, compared with the well-characterised impact of radiation exposure on cell biology, the structural, functional, and ultimately clinical consequences of ECM irradiation remain poorly defined. MDPI 2021-11-05 /pmc/articles/PMC8616186/ /pubmed/34831262 http://dx.doi.org/10.3390/cells10113041 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tuieng, Ren Jie
Cartmell, Sarah H.
Kirwan, Cliona C.
Sherratt, Michael J.
The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins
title The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins
title_full The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins
title_fullStr The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins
title_full_unstemmed The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins
title_short The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins
title_sort effects of ionising and non-ionising electromagnetic radiation on extracellular matrix proteins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616186/
https://www.ncbi.nlm.nih.gov/pubmed/34831262
http://dx.doi.org/10.3390/cells10113041
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