Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy

As the number of confirmed cases and deaths occurring from Coronavirus disease 2019 (COVID-19) surges worldwide, health experts are striving hard to fully comprehend the extent of damage caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although COVID-19 primarily manifests...

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Autores principales: Bhalerao, Aditya, Raut, Snehal, Noorani, Behnam, Mancuso, Salvatore, Cucullo, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616204/
https://www.ncbi.nlm.nih.gov/pubmed/34831101
http://dx.doi.org/10.3390/cells10112878
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author Bhalerao, Aditya
Raut, Snehal
Noorani, Behnam
Mancuso, Salvatore
Cucullo, Luca
author_facet Bhalerao, Aditya
Raut, Snehal
Noorani, Behnam
Mancuso, Salvatore
Cucullo, Luca
author_sort Bhalerao, Aditya
collection PubMed
description As the number of confirmed cases and deaths occurring from Coronavirus disease 2019 (COVID-19) surges worldwide, health experts are striving hard to fully comprehend the extent of damage caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although COVID-19 primarily manifests itself in the form of severe respiratory distress, it is also known to cause systemic damage to almost all major organs and organ systems within the body. In this review, we discuss the molecular mechanisms leading to multi-organ failure seen in COVID-19 patients. We also examine the potential of stem cell therapy in treating COVID-19 multi-organ failure cases.
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spelling pubmed-86162042021-11-26 Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy Bhalerao, Aditya Raut, Snehal Noorani, Behnam Mancuso, Salvatore Cucullo, Luca Cells Review As the number of confirmed cases and deaths occurring from Coronavirus disease 2019 (COVID-19) surges worldwide, health experts are striving hard to fully comprehend the extent of damage caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although COVID-19 primarily manifests itself in the form of severe respiratory distress, it is also known to cause systemic damage to almost all major organs and organ systems within the body. In this review, we discuss the molecular mechanisms leading to multi-organ failure seen in COVID-19 patients. We also examine the potential of stem cell therapy in treating COVID-19 multi-organ failure cases. MDPI 2021-10-25 /pmc/articles/PMC8616204/ /pubmed/34831101 http://dx.doi.org/10.3390/cells10112878 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bhalerao, Aditya
Raut, Snehal
Noorani, Behnam
Mancuso, Salvatore
Cucullo, Luca
Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy
title Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy
title_full Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy
title_fullStr Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy
title_full_unstemmed Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy
title_short Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy
title_sort molecular mechanisms of multi-organ failure in covid-19 and potential of stem cell therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616204/
https://www.ncbi.nlm.nih.gov/pubmed/34831101
http://dx.doi.org/10.3390/cells10112878
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